The Effect of SARS-CoV-2 Virus Infection on the Course of Atopic Dermatitis in Patients
<i>Background and Objectives</i>: Atopic dermatitis (AD) is a disease with a complex pathophysiology involving immune-mediated reactions that lead to skin lesions that are typically localized and recurrent. Following the outbreak of the COVID-19 (coronavirus disease 2019) pandemic, attem...
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| Format: | Article |
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MDPI AG
2021-05-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/6/521 |
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| author | Martyna Miodońska Agnieszka Bogacz Magdalena Mróz Szymon Mućka Andrzej Bożek |
| author_facet | Martyna Miodońska Agnieszka Bogacz Magdalena Mróz Szymon Mućka Andrzej Bożek |
| author_sort | Martyna Miodońska |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Atopic dermatitis (AD) is a disease with a complex pathophysiology involving immune-mediated reactions that lead to skin lesions that are typically localized and recurrent. Following the outbreak of the COVID-19 (coronavirus disease 2019) pandemic, attempting to assess the impact of SARS-CoV-2 infection on diseases caused by complex immune mechanisms has become important. The aim of this study was to assess the impact of SARS-CoV-2 infection on the course of AD, including immunosuppressive therapy, in patients with a severe form of the disease. <i>Materials and Methods</i>: A retrospective analysis of 21 adults aged 18 to 52 years with AD diagnosed with COVID-19, including patients requiring hospitalization, was performed. <i>Results</i>: During SARS-CoV-2 infection, temporary exacerbation of skin lesions and/or skin pruritus was observed in nine (43%) patients but without the need for systemic treatment intervention. Patients with severe AD who received immunosuppressive therapy most often manifested mild exacerbation of skin symptoms. The skin condition improved in three patients. There was no significant effect of disease severity on the risk of severe COVID-19 (HR = 0.45; 95% CI: 0.32–0.65). <i>Conclusions</i>: The course of atopic dermatitis during SARS-CoV-2 infection may be different from the severity of its symptoms due to the lack of a significant influence. The immunosuppressive treatment used in patients with severe AD did not significantly affect the course of SARS-CoV-2 infection. |
| first_indexed | 2024-03-10T11:09:18Z |
| format | Article |
| id | doaj.art-642f2d5b3f7047adbdcbb55dde2ece21 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T11:09:18Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-642f2d5b3f7047adbdcbb55dde2ece212023-11-21T20:56:24ZengMDPI AGMedicina1010-660X1648-91442021-05-0157652110.3390/medicina57060521The Effect of SARS-CoV-2 Virus Infection on the Course of Atopic Dermatitis in PatientsMartyna Miodońska0Agnieszka Bogacz1Magdalena Mróz2Szymon Mućka3Andrzej Bożek4Clinical Department of Internal Disease, Dermatology and Allergology in Zabrze, Medical University of Silesia, 40-055 Katowice, PolandClinical Department of Internal Disease, Dermatology and Allergology in Zabrze, Medical University of Silesia, 40-055 Katowice, PolandClinical Department of Internal Disease, Dermatology and Allergology in Zabrze, Medical University of Silesia, 40-055 Katowice, PolandClinical Department of Internal Disease, Dermatology and Allergology in Zabrze, Medical University of Silesia, 40-055 Katowice, PolandClinical Department of Internal Disease, Dermatology and Allergology in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland<i>Background and Objectives</i>: Atopic dermatitis (AD) is a disease with a complex pathophysiology involving immune-mediated reactions that lead to skin lesions that are typically localized and recurrent. Following the outbreak of the COVID-19 (coronavirus disease 2019) pandemic, attempting to assess the impact of SARS-CoV-2 infection on diseases caused by complex immune mechanisms has become important. The aim of this study was to assess the impact of SARS-CoV-2 infection on the course of AD, including immunosuppressive therapy, in patients with a severe form of the disease. <i>Materials and Methods</i>: A retrospective analysis of 21 adults aged 18 to 52 years with AD diagnosed with COVID-19, including patients requiring hospitalization, was performed. <i>Results</i>: During SARS-CoV-2 infection, temporary exacerbation of skin lesions and/or skin pruritus was observed in nine (43%) patients but without the need for systemic treatment intervention. Patients with severe AD who received immunosuppressive therapy most often manifested mild exacerbation of skin symptoms. The skin condition improved in three patients. There was no significant effect of disease severity on the risk of severe COVID-19 (HR = 0.45; 95% CI: 0.32–0.65). <i>Conclusions</i>: The course of atopic dermatitis during SARS-CoV-2 infection may be different from the severity of its symptoms due to the lack of a significant influence. The immunosuppressive treatment used in patients with severe AD did not significantly affect the course of SARS-CoV-2 infection.https://www.mdpi.com/1648-9144/57/6/521COVID-19atopic dermatitisimmunosuppression |
| spellingShingle | Martyna Miodońska Agnieszka Bogacz Magdalena Mróz Szymon Mućka Andrzej Bożek The Effect of SARS-CoV-2 Virus Infection on the Course of Atopic Dermatitis in Patients Medicina COVID-19 atopic dermatitis immunosuppression |
| title | The Effect of SARS-CoV-2 Virus Infection on the Course of Atopic Dermatitis in Patients |
| title_full | The Effect of SARS-CoV-2 Virus Infection on the Course of Atopic Dermatitis in Patients |
| title_fullStr | The Effect of SARS-CoV-2 Virus Infection on the Course of Atopic Dermatitis in Patients |
| title_full_unstemmed | The Effect of SARS-CoV-2 Virus Infection on the Course of Atopic Dermatitis in Patients |
| title_short | The Effect of SARS-CoV-2 Virus Infection on the Course of Atopic Dermatitis in Patients |
| title_sort | effect of sars cov 2 virus infection on the course of atopic dermatitis in patients |
| topic | COVID-19 atopic dermatitis immunosuppression |
| url | https://www.mdpi.com/1648-9144/57/6/521 |
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