Lateral orbitofrontal cortex promotes trial-by-trial learning of risky, but not spatial, biases
Individual choices are not made in isolation but are embedded in a series of past experiences, decisions, and outcomes. The effects of past experiences on choices, often called sequential biases, are ubiquitous in perceptual and value-based decision-making, but their neural substrates are unclear. W...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2019-11-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/49744 |
| _version_ | 1811181542433619968 |
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| author | Christine M Constantinople Alex T Piet Peter Bibawi Athena Akrami Charles Kopec Carlos D Brody |
| author_facet | Christine M Constantinople Alex T Piet Peter Bibawi Athena Akrami Charles Kopec Carlos D Brody |
| author_sort | Christine M Constantinople |
| collection | DOAJ |
| description | Individual choices are not made in isolation but are embedded in a series of past experiences, decisions, and outcomes. The effects of past experiences on choices, often called sequential biases, are ubiquitous in perceptual and value-based decision-making, but their neural substrates are unclear. We trained rats to choose between cued guaranteed and probabilistic rewards in a task in which outcomes on each trial were independent. Behavioral variability often reflected sequential effects, including increased willingness to take risks following risky wins, and spatial ‘win-stay/lose-shift’ biases. Recordings from lateral orbitofrontal cortex (lOFC) revealed encoding of reward history and receipt, and optogenetic inhibition of lOFC eliminated rats’ increased preference for risk following risky wins, but spared other sequential effects. Our data show that different sequential biases are neurally dissociable, and the lOFC’s role in adaptive behavior promotes learning of more abstract biases (here, biases for the risky option), but not spatial ones. |
| first_indexed | 2024-04-11T09:19:11Z |
| format | Article |
| id | doaj.art-642f31ed144d4547bf09819349976c93 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:19:11Z |
| publishDate | 2019-11-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-642f31ed144d4547bf09819349976c932022-12-22T04:32:15ZengeLife Sciences Publications LtdeLife2050-084X2019-11-01810.7554/eLife.49744Lateral orbitofrontal cortex promotes trial-by-trial learning of risky, but not spatial, biasesChristine M Constantinople0https://orcid.org/0000-0003-4435-4460Alex T Piet1https://orcid.org/0000-0002-6529-1414Peter Bibawi2Athena Akrami3Charles Kopec4Carlos D Brody5https://orcid.org/0000-0002-4201-561XPrinceton Neuroscience Institute, Princeton University, Princeton, United StatesPrinceton Neuroscience Institute, Princeton University, Princeton, United StatesPrinceton Neuroscience Institute, Princeton University, Princeton, United StatesPrinceton Neuroscience Institute, Princeton University, Princeton, United States; Department of Molecular Biology, Princeton University, Princeton, United States; Howard Hughes Medical Institute, Princeton University, Princeton, United StatesPrinceton Neuroscience Institute, Princeton University, Princeton, United States; Department of Molecular Biology, Princeton University, Princeton, United StatesPrinceton Neuroscience Institute, Princeton University, Princeton, United States; Department of Molecular Biology, Princeton University, Princeton, United States; Howard Hughes Medical Institute, Princeton University, Princeton, United StatesIndividual choices are not made in isolation but are embedded in a series of past experiences, decisions, and outcomes. The effects of past experiences on choices, often called sequential biases, are ubiquitous in perceptual and value-based decision-making, but their neural substrates are unclear. We trained rats to choose between cued guaranteed and probabilistic rewards in a task in which outcomes on each trial were independent. Behavioral variability often reflected sequential effects, including increased willingness to take risks following risky wins, and spatial ‘win-stay/lose-shift’ biases. Recordings from lateral orbitofrontal cortex (lOFC) revealed encoding of reward history and receipt, and optogenetic inhibition of lOFC eliminated rats’ increased preference for risk following risky wins, but spared other sequential effects. Our data show that different sequential biases are neurally dissociable, and the lOFC’s role in adaptive behavior promotes learning of more abstract biases (here, biases for the risky option), but not spatial ones.https://elifesciences.org/articles/49744decision-makingorbitofrontal cortexsequential biaslearningreinforcement learning |
| spellingShingle | Christine M Constantinople Alex T Piet Peter Bibawi Athena Akrami Charles Kopec Carlos D Brody Lateral orbitofrontal cortex promotes trial-by-trial learning of risky, but not spatial, biases eLife decision-making orbitofrontal cortex sequential bias learning reinforcement learning |
| title | Lateral orbitofrontal cortex promotes trial-by-trial learning of risky, but not spatial, biases |
| title_full | Lateral orbitofrontal cortex promotes trial-by-trial learning of risky, but not spatial, biases |
| title_fullStr | Lateral orbitofrontal cortex promotes trial-by-trial learning of risky, but not spatial, biases |
| title_full_unstemmed | Lateral orbitofrontal cortex promotes trial-by-trial learning of risky, but not spatial, biases |
| title_short | Lateral orbitofrontal cortex promotes trial-by-trial learning of risky, but not spatial, biases |
| title_sort | lateral orbitofrontal cortex promotes trial by trial learning of risky but not spatial biases |
| topic | decision-making orbitofrontal cortex sequential bias learning reinforcement learning |
| url | https://elifesciences.org/articles/49744 |
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