Toll-like receptor chaperone HSP90B1 and the immune response to Mycobacteria.

Toll-like receptor chaperone HSP90B1 and the immune response to Mycobacteria.

<h4>Rationale</h4>HSP90B1, also known as gp96, is a chaperone for multiple Toll-like receptors (TLRs) and is necessary for TLR-mediated inflammatory responses in murine myeloid cells. The molecule is also expressed in T-cells though its specific role is unknown. We hypothesized that huma...

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Main Authors: Andrew D Graustein, Elizabeth A Misch, Munyaradzi Musvosvi, Muki Shey, Javeed A Shah, Chetan Seshadri, Augustine Ajuogu, Kathryn Bowman, Humphrey Mulenga, Ashley Veldsman, Willem A Hanekom, Mark Hatherill, Thomas J Scriba, Thomas R Hawn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0208940

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