Trifluoperazine induces cellular apoptosis by inhibiting autophagy and targeting NUPR1 in multiple myeloma

Trifluoperazine induces cellular apoptosis by inhibiting autophagy and targeting NUPR1 in multiple myeloma

Multiple myeloma (MM) is the second most common hematologic malignancy of immunoglobulin‐secreting plasma cells. Recent modern combination therapies have improved survival rates, but many patients develop resistance to novel drugs, leading to relapse. Trifluoperazine (TFP), a typical antipsychotic d...

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Bibliographic Details
Main Authors: Anmao Li, Xuanxin Chen, Zizi Jing, Jianbin Chen
Format: Article
Language:English
Published: Wiley 2020-10-01
Series:FEBS Open Bio
Subjects:
apoptosis
autophagy
multiple myeloma
nuclear protein 1
trifluoperazine
Online Access:https://doi.org/10.1002/2211-5463.12960

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