Contribution of Model Organisms to Investigating the Far-Reaching Consequences of PRPP Metabolism on Human Health and Well-Being

Contribution of Model Organisms to Investigating the Far-Reaching Consequences of PRPP Metabolism on Human Health and Well-Being

Phosphoribosyl pyrophosphate synthetase (PRS EC 2.7.6.1) is a rate-limiting enzyme that irreversibly catalyzes the formation of phosphoribosyl pyrophosphate (PRPP) from ribose-5-phosphate and adenosine triphosphate (ATP). This key metabolite is required for the synthesis of purine and pyrimidine nuc...

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Bibliographic Details
Main Authors: Eziuche A. Ugbogu, Lilian M. Schweizer, Michael Schweizer
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cells
Subjects:
phosphoribosyl pyrophosphate synthetase (PRS/PRPS)
eukaryotic model organisms
<i>Saccharomyces cerevisiae</i>
<i>Danio rerio</i>
human neuropathies: Arts syndrome
CMTX5
Online Access:https://www.mdpi.com/2073-4409/11/12/1909

Internet

https://www.mdpi.com/2073-4409/11/12/1909

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