Emerging roles of miRNAs in neuropathic pain: From new findings to novel mechanisms
Neuropathic pain, which results from damage to the somatosensory nervous system, is a global clinical condition that affects many people. Neuropathic pain imposes significant economic and public health burdens and is often difficult to manage because the underlying mechanisms remain unclear. However...
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| Format: | Article |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1110975/full |
| _version_ | 1797904149114781696 |
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| author | Yu-Ying Zhao Yu-Ying Zhao Zi-Jun Wu Zi-Jun Wu Li-Juan Zhu Li-Juan Zhu Tong-Xiang Niu Tong-Xiang Niu Bin Liu Bin Liu Jing Li Jing Li |
| author_facet | Yu-Ying Zhao Yu-Ying Zhao Zi-Jun Wu Zi-Jun Wu Li-Juan Zhu Li-Juan Zhu Tong-Xiang Niu Tong-Xiang Niu Bin Liu Bin Liu Jing Li Jing Li |
| author_sort | Yu-Ying Zhao |
| collection | DOAJ |
| description | Neuropathic pain, which results from damage to the somatosensory nervous system, is a global clinical condition that affects many people. Neuropathic pain imposes significant economic and public health burdens and is often difficult to manage because the underlying mechanisms remain unclear. However, mounting evidence indicates a role for neurogenic inflammation and neuroinflammation in pain pattern development. There is increasing evidence that the activation of neurogenic inflammation and neuroinflammation in the nervous system contribute to neuropathic pain. Altered miRNA expression profiles might be involved in the pathogenesis of both inflammatory and neuropathic pain by regulating neuroinflammation, nerve regeneration, and abnormal ion channel expression. However, the lack of knowledge about miRNA target genes prevents a full understanding of the biological functions of miRNAs. At the same time, an extensive study on exosomal miRNA, a newly discovered role, has advanced our understanding of the pathophysiology of neuropathic pain in recent years. This section provides a comprehensive overview of the current understanding of miRNA research and discusses the potential mechanisms of miRNAs in neuropathic pain. |
| first_indexed | 2024-04-10T09:44:12Z |
| format | Article |
| id | doaj.art-64303267144c49038366f705f99ad4cd |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-04-10T09:44:12Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-64303267144c49038366f705f99ad4cd2023-02-17T05:35:51ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992023-02-011610.3389/fnmol.2023.11109751110975Emerging roles of miRNAs in neuropathic pain: From new findings to novel mechanismsYu-Ying Zhao0Yu-Ying Zhao1Zi-Jun Wu2Zi-Jun Wu3Li-Juan Zhu4Li-Juan Zhu5Tong-Xiang Niu6Tong-Xiang Niu7Bin Liu8Bin Liu9Jing Li10Jing Li11Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, ChinaTianjin Research Institute of Anesthesiology, Tianjin, ChinaDepartment of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, ChinaTianjin Research Institute of Anesthesiology, Tianjin, ChinaDepartment of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, ChinaTianjin Research Institute of Anesthesiology, Tianjin, ChinaDepartment of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, ChinaTianjin Research Institute of Anesthesiology, Tianjin, ChinaDepartment of Critical Care Medicine, General Hospital of Tianjin Medical University, Tianjin, ChinaCenter for Critical Care Medicine, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, ChinaDepartment of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, ChinaTianjin Research Institute of Anesthesiology, Tianjin, ChinaNeuropathic pain, which results from damage to the somatosensory nervous system, is a global clinical condition that affects many people. Neuropathic pain imposes significant economic and public health burdens and is often difficult to manage because the underlying mechanisms remain unclear. However, mounting evidence indicates a role for neurogenic inflammation and neuroinflammation in pain pattern development. There is increasing evidence that the activation of neurogenic inflammation and neuroinflammation in the nervous system contribute to neuropathic pain. Altered miRNA expression profiles might be involved in the pathogenesis of both inflammatory and neuropathic pain by regulating neuroinflammation, nerve regeneration, and abnormal ion channel expression. However, the lack of knowledge about miRNA target genes prevents a full understanding of the biological functions of miRNAs. At the same time, an extensive study on exosomal miRNA, a newly discovered role, has advanced our understanding of the pathophysiology of neuropathic pain in recent years. This section provides a comprehensive overview of the current understanding of miRNA research and discusses the potential mechanisms of miRNAs in neuropathic pain.https://www.frontiersin.org/articles/10.3389/fnmol.2023.1110975/fullneuropathic painmiRNAsexosomesneuroinflammationreview |
| spellingShingle | Yu-Ying Zhao Yu-Ying Zhao Zi-Jun Wu Zi-Jun Wu Li-Juan Zhu Li-Juan Zhu Tong-Xiang Niu Tong-Xiang Niu Bin Liu Bin Liu Jing Li Jing Li Emerging roles of miRNAs in neuropathic pain: From new findings to novel mechanisms Frontiers in Molecular Neuroscience neuropathic pain miRNAs exosomes neuroinflammation review |
| title | Emerging roles of miRNAs in neuropathic pain: From new findings to novel mechanisms |
| title_full | Emerging roles of miRNAs in neuropathic pain: From new findings to novel mechanisms |
| title_fullStr | Emerging roles of miRNAs in neuropathic pain: From new findings to novel mechanisms |
| title_full_unstemmed | Emerging roles of miRNAs in neuropathic pain: From new findings to novel mechanisms |
| title_short | Emerging roles of miRNAs in neuropathic pain: From new findings to novel mechanisms |
| title_sort | emerging roles of mirnas in neuropathic pain from new findings to novel mechanisms |
| topic | neuropathic pain miRNAs exosomes neuroinflammation review |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1110975/full |
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