The Importance of Metabolism for Immune Homeostasis in Allergic Diseases
There is increasing evidence that the metabolic status of T cells and macrophages is associated with severe phenotypes of chronic inflammation, including allergic inflammation. Metabolic changes in immune cells have a crucial role in their inflammatory or regulatory responses. This notion is reinfor...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.692004/full |
| _version_ | 1818921124731289600 |
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| author | Juan Rodriguez-Coira Juan Rodriguez-Coira Juan Rodriguez-Coira Alma Villaseñor Alma Villaseñor Elena Izquierdo Mengting Huang Tomás Clive Barker-Tejeda Tomás Clive Barker-Tejeda Urszula Radzikowska Milena Sokolowska Domingo Barber |
| author_facet | Juan Rodriguez-Coira Juan Rodriguez-Coira Juan Rodriguez-Coira Alma Villaseñor Alma Villaseñor Elena Izquierdo Mengting Huang Tomás Clive Barker-Tejeda Tomás Clive Barker-Tejeda Urszula Radzikowska Milena Sokolowska Domingo Barber |
| author_sort | Juan Rodriguez-Coira |
| collection | DOAJ |
| description | There is increasing evidence that the metabolic status of T cells and macrophages is associated with severe phenotypes of chronic inflammation, including allergic inflammation. Metabolic changes in immune cells have a crucial role in their inflammatory or regulatory responses. This notion is reinforced by metabolic diseases influencing global energy metabolism, such as diabetes or obesity, which are known risk factors of severity in inflammatory conditions, due to the metabolic-associated inflammation present in these patients. Since several metabolic pathways are closely tied to T cell and macrophage differentiation, a better understanding of metabolic alterations in immune disorders could help to restore and modulate immune cell functions. This link between energy metabolism and inflammation can be studied employing animal, human or cellular models. Analytical approaches rank from classic immunological studies to integrated analysis of metabolomics, transcriptomics, and proteomics. This review summarizes the main metabolic pathways of the cells involved in the allergic reaction with a focus on T cells and macrophages and describes different models and platforms of analysis used to study the immune system and its relationship with metabolism. |
| first_indexed | 2024-12-20T01:32:40Z |
| format | Article |
| id | doaj.art-64322871fa8d4fa78e0db19b26fd4731 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-20T01:32:40Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-64322871fa8d4fa78e0db19b26fd47312022-12-21T19:58:05ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-07-011210.3389/fimmu.2021.692004692004The Importance of Metabolism for Immune Homeostasis in Allergic DiseasesJuan Rodriguez-Coira0Juan Rodriguez-Coira1Juan Rodriguez-Coira2Alma Villaseñor3Alma Villaseñor4Elena Izquierdo5Mengting Huang6Tomás Clive Barker-Tejeda7Tomás Clive Barker-Tejeda8Urszula Radzikowska9Milena Sokolowska10Domingo Barber11Departamento de Ciencias Medicas Basicas, Instituto de Medicina Molecular Aplicada (IMMA), Facultad de Medicina, Universidad San Pablo-CEU, CEU Universities, Boadilla Del Monte, Madrid, SpainCentre for Metabolomics and Bioanalysis (CEMBIO), Department of Chemistry and Biochemistry, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Boadilla Del Monte, Madrid, SpainSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos Wolfgang, SwitzerlandDepartamento de Ciencias Medicas Basicas, Instituto de Medicina Molecular Aplicada (IMMA), Facultad de Medicina, Universidad San Pablo-CEU, CEU Universities, Boadilla Del Monte, Madrid, SpainCentre for Metabolomics and Bioanalysis (CEMBIO), Department of Chemistry and Biochemistry, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Boadilla Del Monte, Madrid, SpainDepartamento de Ciencias Medicas Basicas, Instituto de Medicina Molecular Aplicada (IMMA), Facultad de Medicina, Universidad San Pablo-CEU, CEU Universities, Boadilla Del Monte, Madrid, SpainSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos Wolfgang, SwitzerlandDepartamento de Ciencias Medicas Basicas, Instituto de Medicina Molecular Aplicada (IMMA), Facultad de Medicina, Universidad San Pablo-CEU, CEU Universities, Boadilla Del Monte, Madrid, SpainCentre for Metabolomics and Bioanalysis (CEMBIO), Department of Chemistry and Biochemistry, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Boadilla Del Monte, Madrid, SpainSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos Wolfgang, SwitzerlandSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos Wolfgang, SwitzerlandDepartamento de Ciencias Medicas Basicas, Instituto de Medicina Molecular Aplicada (IMMA), Facultad de Medicina, Universidad San Pablo-CEU, CEU Universities, Boadilla Del Monte, Madrid, SpainThere is increasing evidence that the metabolic status of T cells and macrophages is associated with severe phenotypes of chronic inflammation, including allergic inflammation. Metabolic changes in immune cells have a crucial role in their inflammatory or regulatory responses. This notion is reinforced by metabolic diseases influencing global energy metabolism, such as diabetes or obesity, which are known risk factors of severity in inflammatory conditions, due to the metabolic-associated inflammation present in these patients. Since several metabolic pathways are closely tied to T cell and macrophage differentiation, a better understanding of metabolic alterations in immune disorders could help to restore and modulate immune cell functions. This link between energy metabolism and inflammation can be studied employing animal, human or cellular models. Analytical approaches rank from classic immunological studies to integrated analysis of metabolomics, transcriptomics, and proteomics. This review summarizes the main metabolic pathways of the cells involved in the allergic reaction with a focus on T cells and macrophages and describes different models and platforms of analysis used to study the immune system and its relationship with metabolism.https://www.frontiersin.org/articles/10.3389/fimmu.2021.692004/fullallergyimmunometabolismimmune cellsmetabolic regulation-omics |
| spellingShingle | Juan Rodriguez-Coira Juan Rodriguez-Coira Juan Rodriguez-Coira Alma Villaseñor Alma Villaseñor Elena Izquierdo Mengting Huang Tomás Clive Barker-Tejeda Tomás Clive Barker-Tejeda Urszula Radzikowska Milena Sokolowska Domingo Barber The Importance of Metabolism for Immune Homeostasis in Allergic Diseases Frontiers in Immunology allergy immunometabolism immune cells metabolic regulation -omics |
| title | The Importance of Metabolism for Immune Homeostasis in Allergic Diseases |
| title_full | The Importance of Metabolism for Immune Homeostasis in Allergic Diseases |
| title_fullStr | The Importance of Metabolism for Immune Homeostasis in Allergic Diseases |
| title_full_unstemmed | The Importance of Metabolism for Immune Homeostasis in Allergic Diseases |
| title_short | The Importance of Metabolism for Immune Homeostasis in Allergic Diseases |
| title_sort | importance of metabolism for immune homeostasis in allergic diseases |
| topic | allergy immunometabolism immune cells metabolic regulation -omics |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.692004/full |
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