Serial Changes in Body Composition and the Association with Disease Activity during Treatment in Patients with Crohn’s Disease
Objectives: To analyze serial changes in body composition and investigate the association between body composition changes and disease activity changes in patients with Crohn’s disease (CD). Methods: Seventy-one patients with CD who had been treated and followed-up at our institution were included....
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/11/2804 |
| _version_ | 1797465575228702720 |
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| author | Ji Young Lee Kyung Won Kim Yousun Ko Chi Hyuk Oh Bo Hyun Kim Seong Jin Park Myung-Won You |
| author_facet | Ji Young Lee Kyung Won Kim Yousun Ko Chi Hyuk Oh Bo Hyun Kim Seong Jin Park Myung-Won You |
| author_sort | Ji Young Lee |
| collection | DOAJ |
| description | Objectives: To analyze serial changes in body composition and investigate the association between body composition changes and disease activity changes in patients with Crohn’s disease (CD). Methods: Seventy-one patients with CD who had been treated and followed-up at our institution were included. Two to four computed tomography images were acquired at baseline, and the 2–5-year, 5–8-year, and last follow-ups were selected per patient for body composition and disease activity analyses. Visceral fat area (VFA), skeletal muscle index (SMI; skeletal muscle area/height<sup>2</sup>), and subcutaneous fat area (SFA) were assessed using an artificial-intelligence-driven fully automated method. Disease activity was assessed using a modified computed tomography scoring system and the Simple Endoscopic Score for Crohn’s Disease. The associations between body composition, disease activity, and remission were investigated. Results: The mean age was 29.83 ± 11.27 years; most patients were men (48/71, 67.6%); and the median follow-up was 144 (12–264) months. Overall, VFA and SFA gradually increased, while SMI decreased during the follow-up. Sarcopenia was associated with the female sex, higher disease activities at baseline (<i>p</i> = 0.01) and the last follow-up (<i>p</i> = 0.001). SMI and SFA inversely correlated with the disease activity, i.e., the more severe the disease activity, the lower the SMI and SFA (<i>p</i> < 0.05). SMI at the last follow-up was the only significant predictor of remission (OR = 1.21, 95% confidence interval: 1.03–1.42, <i>p</i> = 0.021). Conclusion: SMI decreased while VFA and SFA increased during the treatment follow-up in patients with CD. Sarcopenia was associated with higher disease activity, and SMI and SFA inversely correlated with disease activity. SMI at the last follow-up was the significant factor for remission. |
| first_indexed | 2024-03-09T18:23:24Z |
| format | Article |
| id | doaj.art-643247875acf4108b3d9e33c7938f038 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T18:23:24Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-643247875acf4108b3d9e33c7938f0382023-11-24T08:04:31ZengMDPI AGDiagnostics2075-44182022-11-011211280410.3390/diagnostics12112804Serial Changes in Body Composition and the Association with Disease Activity during Treatment in Patients with Crohn’s DiseaseJi Young Lee0Kyung Won Kim1Yousun Ko2Chi Hyuk Oh3Bo Hyun Kim4Seong Jin Park5Myung-Won You6Department of Radiology, Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul 02447, Republic of KoreaDepartment of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Republic of KoreaBiomedical Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Republic of KoreaDepartment of Gastroenterology, Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul 02447, Republic of KoreaDepartment of Radiology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of KoreaDepartment of Radiology, Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul 02447, Republic of KoreaDepartment of Radiology, Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul 02447, Republic of KoreaObjectives: To analyze serial changes in body composition and investigate the association between body composition changes and disease activity changes in patients with Crohn’s disease (CD). Methods: Seventy-one patients with CD who had been treated and followed-up at our institution were included. Two to four computed tomography images were acquired at baseline, and the 2–5-year, 5–8-year, and last follow-ups were selected per patient for body composition and disease activity analyses. Visceral fat area (VFA), skeletal muscle index (SMI; skeletal muscle area/height<sup>2</sup>), and subcutaneous fat area (SFA) were assessed using an artificial-intelligence-driven fully automated method. Disease activity was assessed using a modified computed tomography scoring system and the Simple Endoscopic Score for Crohn’s Disease. The associations between body composition, disease activity, and remission were investigated. Results: The mean age was 29.83 ± 11.27 years; most patients were men (48/71, 67.6%); and the median follow-up was 144 (12–264) months. Overall, VFA and SFA gradually increased, while SMI decreased during the follow-up. Sarcopenia was associated with the female sex, higher disease activities at baseline (<i>p</i> = 0.01) and the last follow-up (<i>p</i> = 0.001). SMI and SFA inversely correlated with the disease activity, i.e., the more severe the disease activity, the lower the SMI and SFA (<i>p</i> < 0.05). SMI at the last follow-up was the only significant predictor of remission (OR = 1.21, 95% confidence interval: 1.03–1.42, <i>p</i> = 0.021). Conclusion: SMI decreased while VFA and SFA increased during the treatment follow-up in patients with CD. Sarcopenia was associated with higher disease activity, and SMI and SFA inversely correlated with disease activity. SMI at the last follow-up was the significant factor for remission.https://www.mdpi.com/2075-4418/12/11/2804body compositionCrohn’s diseasedisease activityremission |
| spellingShingle | Ji Young Lee Kyung Won Kim Yousun Ko Chi Hyuk Oh Bo Hyun Kim Seong Jin Park Myung-Won You Serial Changes in Body Composition and the Association with Disease Activity during Treatment in Patients with Crohn’s Disease Diagnostics body composition Crohn’s disease disease activity remission |
| title | Serial Changes in Body Composition and the Association with Disease Activity during Treatment in Patients with Crohn’s Disease |
| title_full | Serial Changes in Body Composition and the Association with Disease Activity during Treatment in Patients with Crohn’s Disease |
| title_fullStr | Serial Changes in Body Composition and the Association with Disease Activity during Treatment in Patients with Crohn’s Disease |
| title_full_unstemmed | Serial Changes in Body Composition and the Association with Disease Activity during Treatment in Patients with Crohn’s Disease |
| title_short | Serial Changes in Body Composition and the Association with Disease Activity during Treatment in Patients with Crohn’s Disease |
| title_sort | serial changes in body composition and the association with disease activity during treatment in patients with crohn s disease |
| topic | body composition Crohn’s disease disease activity remission |
| url | https://www.mdpi.com/2075-4418/12/11/2804 |
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