Antimicrobial Resistance Gene Delivery in Animal Feeds
Avoparcin, a glycopeptide antimicrobial agent related to vancomycin, has been used extensively as a growth promoter in animal feeds for more than 2 decades, and evidence has shown that such use contributed to the development of vancomycin-resistant enterococci. A cluster that includes three genes, v...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2004-04-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/10/4/03-0506_article |
| _version_ | 1811300562127290368 |
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| author | Karen Lu Rumi Asano Julian Davies |
| author_facet | Karen Lu Rumi Asano Julian Davies |
| author_sort | Karen Lu |
| collection | DOAJ |
| description | Avoparcin, a glycopeptide antimicrobial agent related to vancomycin, has been used extensively as a growth promoter in animal feeds for more than 2 decades, and evidence has shown that such use contributed to the development of vancomycin-resistant enterococci. A cluster that includes three genes, vanH, vanA, and vanX, is required for high-level resistance to glycopeptides. In the vancomycin producer Amycolatopsis orientalis C329.2, homologs of these genes are present, suggesting an origin for the cluster. We found substantial bacterial DNA contamination in animal-feed-grade avoparcin. Furthermore, nucleotide sequences related to the cluster vanHAX are present in this DNA, suggesting that the prolonged use of avoparcin in agriculture led to the uptake of glycopeptide resistance genes by animal commensal bacteria, which were subsequently transferred to humans. |
| first_indexed | 2024-04-13T06:53:09Z |
| format | Article |
| id | doaj.art-6434a6971a2741169aceae738a79f1b3 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-04-13T06:53:09Z |
| publishDate | 2004-04-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-6434a6971a2741169aceae738a79f1b32022-12-22T02:57:20ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592004-04-0110467968310.3201/eid1004.030506Antimicrobial Resistance Gene Delivery in Animal FeedsKaren LuRumi AsanoJulian DaviesAvoparcin, a glycopeptide antimicrobial agent related to vancomycin, has been used extensively as a growth promoter in animal feeds for more than 2 decades, and evidence has shown that such use contributed to the development of vancomycin-resistant enterococci. A cluster that includes three genes, vanH, vanA, and vanX, is required for high-level resistance to glycopeptides. In the vancomycin producer Amycolatopsis orientalis C329.2, homologs of these genes are present, suggesting an origin for the cluster. We found substantial bacterial DNA contamination in animal-feed-grade avoparcin. Furthermore, nucleotide sequences related to the cluster vanHAX are present in this DNA, suggesting that the prolonged use of avoparcin in agriculture led to the uptake of glycopeptide resistance genes by animal commensal bacteria, which were subsequently transferred to humans.https://wwwnc.cdc.gov/eid/article/10/4/03-0506_articleantimicrobial agentsresistancetherapeuticprophylacticagricultureenterococci |
| spellingShingle | Karen Lu Rumi Asano Julian Davies Antimicrobial Resistance Gene Delivery in Animal Feeds Emerging Infectious Diseases antimicrobial agents resistance therapeutic prophylactic agriculture enterococci |
| title | Antimicrobial Resistance Gene Delivery in Animal Feeds |
| title_full | Antimicrobial Resistance Gene Delivery in Animal Feeds |
| title_fullStr | Antimicrobial Resistance Gene Delivery in Animal Feeds |
| title_full_unstemmed | Antimicrobial Resistance Gene Delivery in Animal Feeds |
| title_short | Antimicrobial Resistance Gene Delivery in Animal Feeds |
| title_sort | antimicrobial resistance gene delivery in animal feeds |
| topic | antimicrobial agents resistance therapeutic prophylactic agriculture enterococci |
| url | https://wwwnc.cdc.gov/eid/article/10/4/03-0506_article |
| work_keys_str_mv | AT karenlu antimicrobialresistancegenedeliveryinanimalfeeds AT rumiasano antimicrobialresistancegenedeliveryinanimalfeeds AT juliandavies antimicrobialresistancegenedeliveryinanimalfeeds |