GIRK-SPECIFIC DRUGS RESCUE ALTERED CHANNEL ACTIVITY IN GNB1 ENCEPHALOPATHY

GIRK-SPECIFIC DRUGS RESCUE ALTERED CHANNEL ACTIVITY IN GNB1 ENCEPHALOPATHY

Bibliographic Details
Main Authors:	Haritha Reddy, Daniel Yakubovitch, Tal Raifman, Maria Pederson, Boris Shalomov, Jonathan Javitch, Amal Bera, Nathan Dascal
Format:	Article
Language:	English
Published:	Elsevier 2023-10-01
Series:	IBRO Neuroscience Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2667242123002178

Similar Items

Encephalopathy-causing mutations in Gβ1 (GNB1) alter regulation of neuronal GIRK channels
by: Haritha P. Reddy, et al.
Published: (2021-09-01)

Epilepsy in a mouse model of GNB1 encephalopathy arises from altered potassium (GIRK) channel signaling and is alleviated by a GIRK inhibitor
by: Sophie Colombo, et al.
Published: (2023-05-01)

CHARACTERIZATION OF DISEASE PHENOTYPE IN MOUSE MODEL (GNB1I80T/+) WITH ENCEPHALOPATHY CAUSING MUTATION IN GΒ1 PROTEIN
by: Haritha Reddy, et al.
Published: (2023-10-01)

A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of Gα and Gβγ.
by: Daniel Yakubovich, et al.
Published: (2015-11-01)

A selectivity filter mutation provides insights into gating regulation of a K+ channel
by: Theres Friesacher, et al.
Published: (2022-04-01)

A Collision Coupling Model Governs the Activation of Neuronal GIRK1/2 Channels by Muscarinic-2 Receptors
by: Shai Berlin, et al.
Published: (2020-08-01)

The Relevance of GIRK Channels in Heart Function
by: Ana Campos-Ríos, et al.
Published: (2022-11-01)

Targeting GIRK Channels for the Development of New Therapeutic Agents
by: Kenneth eWalsh
Published: (2011-10-01)

Nanoscale alterations in GABAB receptors and GIRK channel organization on the hippocampus of APP/PS1 mice
by: Alejandro Martín-Belmonte, et al.
Published: (2022-09-01)

Sensory regulation of absence seizures in a mouse model of Gnb1 encephalopathy
by: Sasa Teng, et al.
Published: (2022-11-01)

GIRK Channels as Candidate Targets for the Treatment of Substance Use Disorders
by: Hiroko Kotajima-Murakami, et al.
Published: (2022-10-01)

Molecular basis of signaling specificity between GIRK channels and GPCRs
by: Kouki K Touhara, et al.
Published: (2018-12-01)

Identification of a G-Protein-Independent Activator of GIRK Channels
by: Yulin Zhao, et al.
Published: (2020-06-01)

Cryo-EM analysis of PIP2 regulation in mammalian GIRK channels
by: Yiming Niu, et al.
Published: (2020-08-01)

Structural insights into GIRK2 channel modulation by cholesterol and PIP2
by: Yamuna Kalyani Mathiharan, et al.
Published: (2021-08-01)

GNB study dataset
by: Bancone, G, et al.
Published: (2022)

The GIRK1 subunit potentiates G protein activation of cardiac GIRK1/4 hetero-tetramers
by: Kouki K Touhara, et al.
Published: (2016-04-01)

Cooperative regulation by G proteins and Na+ of neuronal GIRK2 K+ channels
by: Weiwei Wang, et al.
Published: (2016-04-01)

Selective Inhibition of Pulmonary Vein Excitability by Constitutively Active GIRK Channels Blockade in Rats
by: Ian Findlay, et al.
Published: (2023-09-01)

Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons.
by: Alberto Montalbano, et al.
Published: (2015-01-01)

GIRK2 splice variants and neuronal G protein-gated K+ channels: implications for channel function and behavior
by: Ezequiel Marron Fernandez de Velasco, et al.
Published: (2017-05-01)

Calcium Release from Stores Inhibits GIRK
by: Paul F. Kramer, et al.
Published: (2016-12-01)

Increased GIRK channel activity prevents arrhythmia in mice with heart failure by enhancing ventricular repolarization
by: Xue An, et al.
Published: (2023-12-01)

Ras-association domain of sorting Nexin 27 is critical for regulating expression of GIRK potassium channels.
by: Bartosz Balana, et al.
Published: (2013-01-01)

Atrial GIRK Channels Mediate the Effects of Vagus Nerve Stimulation on Heart Rate Dynamics and Arrhythmogenesis
by: Steven W. Lee, et al.
Published: (2018-07-01)

Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines
by: Schuller Hildegard M, et al.
Published: (2005-08-01)

The Expression and Localisation of G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channels Is Differentially Altered in the Hippocampus of Two Mouse Models of Alzheimer’s Disease
by: Rocío Alfaro-Ruiz, et al.
Published: (2021-10-01)

GIRK2 potassium channels expressed by the AgRP neurons decrease adiposity and body weight in mice.
by: Youjin Oh, et al.
Published: (2023-08-01)

Expression of inwardly rectifying potassium channels (GIRKs) and beta-adrenergic regulation of breast cancer cell lines
by: Cakir Yavuz, et al.
Published: (2004-12-01)

Identification of a unique endoplasmic retention motif in the Xenopus GIRK5 channel and its contribution to oocyte maturation
by: Claudia I. Rangel‐Garcia, et al.
Published: (2021-04-01)

GNB3 overexpression causes obesity and metabolic syndrome.
by: Alev Cagla Ozdemir, et al.
Published: (2017-01-01)

Enhanced GIRK2 channel signaling in Down syndrome: A feasible role in the development of abnormal nascent neural circuits
by: Alexander M. Kleschevnikov
Published: (2022-09-01)

Activin A Reduces GIRK Current to Excite Dentate Gyrus Granule Cells
by: Fang Zheng, et al.
Published: (2022-05-01)

VU0810464, A GIRK CHANNEL ACTIVATOR, COUNTERACTS SYNAPTIC PLASTICITY AND VISUO-SPATIAL MEMORY IMPAIRMENTS IN AN EARLY AMYLOIDOPATHY MOUSE MODEL
by: Jaime Mulero Franco, et al.
Published: (2023-10-01)

Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system
by: Weiwei Wang, et al.
Published: (2014-07-01)

GNB1-Related Rod-Cone Dystrophy: A Case Report
by: Giovanni Marco Conti, et al.
Published: (2024-03-01)

Haploinsufficiency as a disease mechanism in GNB1‐associated neurodevelopmental disorder
by: Laura Schultz‐Rogers, et al.
Published: (2020-11-01)

The Role of Parvalbumin Interneuron GIRK Signaling in the Regulation of Affect and Cognition in Male and Female Mice
by: Eden M. Anderson, et al.
Published: (2021-03-01)

Consequences of somatic mutations of GIRK1 detected in primary malign tumors on expression and function of G-protein activated, inwardly rectifying, K+ channels
by: Brigitte Pelzmann, et al.
Published: (2022-10-01)

The polarization of the G-protein activated potassium channel GIRK5 to the vegetal pole of Xenopus laevis oocytes is driven by a di-leucine motif.
by: Beatriz Díaz-Bello, et al.
Published: (2013-01-01)