Stem cells and their mediators – next generation therapy for bronchopulmonary dysplasia
Bronchopulmonary dysplasia (BPD) remains a major complication of premature birth. Despite great achievements in perinatal medicine over the past decades, there is no treatment for BPD. Recent insights into the biology of stem/progenitor cells have ignited the hope of regenerating damaged organs. Ani...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-07-01
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| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmed.2015.00050/full |
| _version_ | 1811310233364987904 |
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| author | Marius Alexander Möbius Marius Alexander Möbius Marius Alexander Möbius Bernard eThébaud Bernard eThébaud |
| author_facet | Marius Alexander Möbius Marius Alexander Möbius Marius Alexander Möbius Bernard eThébaud Bernard eThébaud |
| author_sort | Marius Alexander Möbius |
| collection | DOAJ |
| description | Bronchopulmonary dysplasia (BPD) remains a major complication of premature birth. Despite great achievements in perinatal medicine over the past decades, there is no treatment for BPD. Recent insights into the biology of stem/progenitor cells have ignited the hope of regenerating damaged organs. Animal experiments revealed promising lung protection/regeneration with stem/progenitor cells in experimental models of BPD and led to first clinical studies in infants. However, these therapies are still experimental and knowledge on the exact mechanisms of action of these cells is limited. Furthermore, heterogeneity of the therapeutic cell populations and missing potency assays limit currently our ability to predict a cell product’s efficacy. In here, we review the therapeutic potential of mesenchymal stromal, endothelial progenitor and amniotic epithelial cells for BPD. Current knowledge on the mechanisms behind the beneficial effects of stem cells is briefly summarized. Finally, we discuss the obstacles constraining their transition from bench to bedside and present potential approaches to overcome them. |
| first_indexed | 2024-04-13T09:55:32Z |
| format | Article |
| id | doaj.art-643975360abb49b39f6a23a093977fec |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-13T09:55:32Z |
| publishDate | 2015-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-643975360abb49b39f6a23a093977fec2022-12-22T02:51:25ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2015-07-01210.3389/fmed.2015.00050147051Stem cells and their mediators – next generation therapy for bronchopulmonary dysplasiaMarius Alexander Möbius0Marius Alexander Möbius1Marius Alexander Möbius2Bernard eThébaud3Bernard eThébaud4Department of Neonatology and Pediatric Critical Care Medicine, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität DresdenDFG Research Center and Cluster of Excellence for Regenerative Therapies (CRTD), Technische Universität DresdenOttawa Hospital Research Institute, Regenerative Medicine Program, Sprott Centre for Stem Cell Research, University of OttawaOttawa Hospital Research Institute, Regenerative Medicine Program, Sprott Centre for Stem Cell Research, University of OttawaDepartment of Pediatrics, Division of Neonatology, Children’s Hospital of Eastern Ontario, University of OttawaBronchopulmonary dysplasia (BPD) remains a major complication of premature birth. Despite great achievements in perinatal medicine over the past decades, there is no treatment for BPD. Recent insights into the biology of stem/progenitor cells have ignited the hope of regenerating damaged organs. Animal experiments revealed promising lung protection/regeneration with stem/progenitor cells in experimental models of BPD and led to first clinical studies in infants. However, these therapies are still experimental and knowledge on the exact mechanisms of action of these cells is limited. Furthermore, heterogeneity of the therapeutic cell populations and missing potency assays limit currently our ability to predict a cell product’s efficacy. In here, we review the therapeutic potential of mesenchymal stromal, endothelial progenitor and amniotic epithelial cells for BPD. Current knowledge on the mechanisms behind the beneficial effects of stem cells is briefly summarized. Finally, we discuss the obstacles constraining their transition from bench to bedside and present potential approaches to overcome them.http://journal.frontiersin.org/Journal/10.3389/fmed.2015.00050/fullBronchopulmonary DysplasiaLungMesenchymal Stromal CellsStem Cellsendothelial progenitor cellsPotency assay |
| spellingShingle | Marius Alexander Möbius Marius Alexander Möbius Marius Alexander Möbius Bernard eThébaud Bernard eThébaud Stem cells and their mediators – next generation therapy for bronchopulmonary dysplasia Frontiers in Medicine Bronchopulmonary Dysplasia Lung Mesenchymal Stromal Cells Stem Cells endothelial progenitor cells Potency assay |
| title | Stem cells and their mediators – next generation therapy for bronchopulmonary dysplasia |
| title_full | Stem cells and their mediators – next generation therapy for bronchopulmonary dysplasia |
| title_fullStr | Stem cells and their mediators – next generation therapy for bronchopulmonary dysplasia |
| title_full_unstemmed | Stem cells and their mediators – next generation therapy for bronchopulmonary dysplasia |
| title_short | Stem cells and their mediators – next generation therapy for bronchopulmonary dysplasia |
| title_sort | stem cells and their mediators next generation therapy for bronchopulmonary dysplasia |
| topic | Bronchopulmonary Dysplasia Lung Mesenchymal Stromal Cells Stem Cells endothelial progenitor cells Potency assay |
| url | http://journal.frontiersin.org/Journal/10.3389/fmed.2015.00050/full |
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