AAV5-mediated manipulation of insulin expression in choroid plexus has long-term metabolic and behavioral consequences

AAV5-mediated manipulation of insulin expression in choroid plexus has long-term metabolic and behavioral consequences

Summary: The choroid plexus (CP) is a source of trophic factors for the developing and mature brain. Insulin is produced in epithelial cells of the CP (EChPs), and its secretion is stimulated by Htr2c-mediated signaling. We modulated insulin expression in EChPs with intracerebroventricular injection...

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Bibliographic Details
Main Authors: Caio Henrique Mazucanti, Vernon Kennedy, Jr., Hasitha U. Premathilake, Maire E. Doyle, Jane Tian, Qing-Rong Liu, Jennifer O’Connell, Simonetta Camandola, Josephine M. Egan
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Cell Reports
Subjects:
CP: Neuroscience
CP: Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723009142

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