High-Throughput Immunogenetics Reveals a Lack of Physiological T Cell Clusters in Patients With Autoimmune Cytopenias

High-Throughput Immunogenetics Reveals a Lack of Physiological T Cell Clusters in Patients With Autoimmune Cytopenias

Autoimmune cytopenias (AIC) such as immune thrombocytopenia or autoimmune hemolytic anemia are claimed to be essentially driven by a dysregulated immune system. Using next-generation immunosequencing we profiled 59 T and B cell repertoires (TRB and IGH) of 25 newly diagnosed patients with primary or...

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Bibliographic Details
Main Authors: Donjete Simnica, Simon Schliffke, Christoph Schultheiß, Nicola Bonzanni, Lorenzo F. Fanchi, Nuray Akyüz, Barbara Gösch, Christian Casar, Benjamin Thiele, Janina Schlüter, Ansgar W. Lohse, Mascha Binder
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
autoimmunity
AIC
CLL
GLIPH
immunosequencing
NGS
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01897/full

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