Predicting One-Year Deaths and Major Adverse Vascular Events with the Controlling Nutritional Status Score in Elderly Patients with Non–ST-Elevated Myocardial Infarction Undergoing Percutaneous Coronary Intervention
The prognostic value of malnutrition in elderly patients with non-ST-elevated myocardial infarction (NSTEMI) is not fully understood. Nutritional characteristics were evaluated by novel Controlling Nutritional status (CONUT), the prognostic nutritional index (PNI) and the geriatric nutritional risk...
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| Format: | Article |
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MDPI AG
2021-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/11/2247 |
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| author | Muhsin Kalyoncuoğlu Fahrettin Katkat Halil Ibrahim Biter Sinem Cakal Aydin Rodi Tosu Mehmet Mustafa Can |
| author_facet | Muhsin Kalyoncuoğlu Fahrettin Katkat Halil Ibrahim Biter Sinem Cakal Aydin Rodi Tosu Mehmet Mustafa Can |
| author_sort | Muhsin Kalyoncuoğlu |
| collection | DOAJ |
| description | The prognostic value of malnutrition in elderly patients with non-ST-elevated myocardial infarction (NSTEMI) is not fully understood. Nutritional characteristics were evaluated by novel Controlling Nutritional status (CONUT), the prognostic nutritional index (PNI) and the geriatric nutritional risk index (GNRI) scores. The impact of these scores on major outcomes in 253 NSTEMI patients over 60 years and older were assessed. Compared to those with good nutritional status; malnourished patients had more major adverse cardiac and cerebrovascular events (MACCEs) at 1-year follow up. Multivariable cox regression analysis revealed that CONUT (hazard ratio = 1.372; <i>p</i> < 0.01) was independent predictor of MACCEs, whereas PNI (<i>p</i> = 0.44) and GNRI (<i>p</i> = 0.52) were not. The discriminating power of the CONUT (AUC: 0.79) was adequate and significantly superior to both the PNI (AUC: 0.68) and the GNRI (AUC: 0.60), with a <i>p</i>-value for both < 0.01. Patients with elevated CONUT exhibited the highest event rate for all-cause mortality and MACCEs in survival analysis (<i>p</i> < 0.01). We conclude that malnutrition is strongly associated with adverse outcomes in older patients with NSTEMI. In fact, the CONUT score adequately predicts one-year MACCEs among elderly NSTEMI patients who achieve complete revascularization after coronary intervention. |
| first_indexed | 2024-03-10T11:09:18Z |
| format | Article |
| id | doaj.art-643d76f311e748ff8b22098b735385cc |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T11:09:18Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-643d76f311e748ff8b22098b735385cc2023-11-21T20:53:01ZengMDPI AGJournal of Clinical Medicine2077-03832021-05-011011224710.3390/jcm10112247Predicting One-Year Deaths and Major Adverse Vascular Events with the Controlling Nutritional Status Score in Elderly Patients with Non–ST-Elevated Myocardial Infarction Undergoing Percutaneous Coronary InterventionMuhsin Kalyoncuoğlu0Fahrettin Katkat1Halil Ibrahim Biter2Sinem Cakal3Aydin Rodi Tosu4Mehmet Mustafa Can5Cardiology Department, Haseki Training and Research Hospital, University of Health Sciences Turkey, Istanbul 34096, TurkeyCardiology Department, Bagcilar Training and Research Hospital, University of Health Sciences Turkey, Istanbul 34200, TurkeyCardiology Department, Haseki Training and Research Hospital, University of Health Sciences Turkey, Istanbul 34096, TurkeyCardiology Department, Haseki Training and Research Hospital, University of Health Sciences Turkey, Istanbul 34096, TurkeyCardiology Department, Haseki Training and Research Hospital, University of Health Sciences Turkey, Istanbul 34096, TurkeyCardiology Department, Haseki Training and Research Hospital, University of Health Sciences Turkey, Istanbul 34096, TurkeyThe prognostic value of malnutrition in elderly patients with non-ST-elevated myocardial infarction (NSTEMI) is not fully understood. Nutritional characteristics were evaluated by novel Controlling Nutritional status (CONUT), the prognostic nutritional index (PNI) and the geriatric nutritional risk index (GNRI) scores. The impact of these scores on major outcomes in 253 NSTEMI patients over 60 years and older were assessed. Compared to those with good nutritional status; malnourished patients had more major adverse cardiac and cerebrovascular events (MACCEs) at 1-year follow up. Multivariable cox regression analysis revealed that CONUT (hazard ratio = 1.372; <i>p</i> < 0.01) was independent predictor of MACCEs, whereas PNI (<i>p</i> = 0.44) and GNRI (<i>p</i> = 0.52) were not. The discriminating power of the CONUT (AUC: 0.79) was adequate and significantly superior to both the PNI (AUC: 0.68) and the GNRI (AUC: 0.60), with a <i>p</i>-value for both < 0.01. Patients with elevated CONUT exhibited the highest event rate for all-cause mortality and MACCEs in survival analysis (<i>p</i> < 0.01). We conclude that malnutrition is strongly associated with adverse outcomes in older patients with NSTEMI. In fact, the CONUT score adequately predicts one-year MACCEs among elderly NSTEMI patients who achieve complete revascularization after coronary intervention.https://www.mdpi.com/2077-0383/10/11/2247agedmyocardial infarctionmalnutritionmortalitymorbidity |
| spellingShingle | Muhsin Kalyoncuoğlu Fahrettin Katkat Halil Ibrahim Biter Sinem Cakal Aydin Rodi Tosu Mehmet Mustafa Can Predicting One-Year Deaths and Major Adverse Vascular Events with the Controlling Nutritional Status Score in Elderly Patients with Non–ST-Elevated Myocardial Infarction Undergoing Percutaneous Coronary Intervention Journal of Clinical Medicine aged myocardial infarction malnutrition mortality morbidity |
| title | Predicting One-Year Deaths and Major Adverse Vascular Events with the Controlling Nutritional Status Score in Elderly Patients with Non–ST-Elevated Myocardial Infarction Undergoing Percutaneous Coronary Intervention |
| title_full | Predicting One-Year Deaths and Major Adverse Vascular Events with the Controlling Nutritional Status Score in Elderly Patients with Non–ST-Elevated Myocardial Infarction Undergoing Percutaneous Coronary Intervention |
| title_fullStr | Predicting One-Year Deaths and Major Adverse Vascular Events with the Controlling Nutritional Status Score in Elderly Patients with Non–ST-Elevated Myocardial Infarction Undergoing Percutaneous Coronary Intervention |
| title_full_unstemmed | Predicting One-Year Deaths and Major Adverse Vascular Events with the Controlling Nutritional Status Score in Elderly Patients with Non–ST-Elevated Myocardial Infarction Undergoing Percutaneous Coronary Intervention |
| title_short | Predicting One-Year Deaths and Major Adverse Vascular Events with the Controlling Nutritional Status Score in Elderly Patients with Non–ST-Elevated Myocardial Infarction Undergoing Percutaneous Coronary Intervention |
| title_sort | predicting one year deaths and major adverse vascular events with the controlling nutritional status score in elderly patients with non st elevated myocardial infarction undergoing percutaneous coronary intervention |
| topic | aged myocardial infarction malnutrition mortality morbidity |
| url | https://www.mdpi.com/2077-0383/10/11/2247 |
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