Tumor size and prognosis in patients with Wilms tumor
OBJECTIVE: Investigate the relationship of the tumor volume after preoperative chemotherapy (TVAPQ) and before preoperative chemotherapy (TVBPQ) with overall survival at two and at five years, and lifetime. METHODS: Our sample consisted of consecutive patients evaluated in the period from 1989 to 20...
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| Format: | Article |
| Language: | English |
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Sociedade de Pediatria de São Paulo
2015-03-01
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| Series: | Revista Paulista de Pediatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822015000100082&lng=en&tlng=en |
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| author | Valentina Oliveira Provenzi Rafael Fabiano Machado Rosa Rosana Cardoso Manique Rosa Adriana Vial Roehe Pedro Paulo Albino dos Santos Fabrízia Rennó Sodero Faulhaber Ceres Andréia Vieira de Oliveira Paulo Ricardo Gazzola Zen |
| author_facet | Valentina Oliveira Provenzi Rafael Fabiano Machado Rosa Rosana Cardoso Manique Rosa Adriana Vial Roehe Pedro Paulo Albino dos Santos Fabrízia Rennó Sodero Faulhaber Ceres Andréia Vieira de Oliveira Paulo Ricardo Gazzola Zen |
| author_sort | Valentina Oliveira Provenzi |
| collection | DOAJ |
| description | OBJECTIVE: Investigate the relationship of the tumor volume after preoperative chemotherapy (TVAPQ) and before preoperative chemotherapy (TVBPQ) with overall survival at two and at five years, and lifetime. METHODS: Our sample consisted of consecutive patients evaluated in the period from 1989 to 2009 in an Onco-Hematology Service. Clinical, histological and volumetric data were collected from the medical records. For analysis, chi-square, Kaplan-Meier, log-rank and Cox regression tests were used. RESULTS: The sample consisted of 32 patients, 53.1% were male with a median age at diagnosis of 43 months. There was a significant association between TVAPQ>500mL and the difference between the TVBPQ and TVAPQ (p=0.015) and histologic types of risk (p=0.008). It was also verified an association between the difference between the TVBPQ and TVAPQ and the predominant stromal tumor (p=0.037). When assessing the TVAPQ of all patients, without a cutoff, there was an association of the variable with lifetime (p=0.013), i.e., for each increase of 10mL in TVAPQ there was an average increase of 2% in the risk of death. CONCLUSIONS: Although our results indicate that the TVAPQ could be considered alone as a predictor of poor prognosis regardless of the cutoff suggested in the literature, more studies are needed to replace the histology and staging by tumor size as best prognostic variable. |
| first_indexed | 2024-12-18T02:53:36Z |
| format | Article |
| id | doaj.art-643ec6f3429c4495b1fb06c96940f5cc |
| institution | Directory Open Access Journal |
| issn | 1984-0462 |
| language | English |
| last_indexed | 2024-12-18T02:53:36Z |
| publishDate | 2015-03-01 |
| publisher | Sociedade de Pediatria de São Paulo |
| record_format | Article |
| series | Revista Paulista de Pediatria |
| spelling | doaj.art-643ec6f3429c4495b1fb06c96940f5cc2022-12-21T21:23:25ZengSociedade de Pediatria de São PauloRevista Paulista de Pediatria1984-04622015-03-01331828710.1016/j.rpped.2014.05.003S0103-05822015000100082Tumor size and prognosis in patients with Wilms tumorValentina Oliveira ProvenziRafael Fabiano Machado RosaRosana Cardoso Manique RosaAdriana Vial RoehePedro Paulo Albino dos SantosFabrízia Rennó Sodero FaulhaberCeres Andréia Vieira de OliveiraPaulo Ricardo Gazzola ZenOBJECTIVE: Investigate the relationship of the tumor volume after preoperative chemotherapy (TVAPQ) and before preoperative chemotherapy (TVBPQ) with overall survival at two and at five years, and lifetime. METHODS: Our sample consisted of consecutive patients evaluated in the period from 1989 to 2009 in an Onco-Hematology Service. Clinical, histological and volumetric data were collected from the medical records. For analysis, chi-square, Kaplan-Meier, log-rank and Cox regression tests were used. RESULTS: The sample consisted of 32 patients, 53.1% were male with a median age at diagnosis of 43 months. There was a significant association between TVAPQ>500mL and the difference between the TVBPQ and TVAPQ (p=0.015) and histologic types of risk (p=0.008). It was also verified an association between the difference between the TVBPQ and TVAPQ and the predominant stromal tumor (p=0.037). When assessing the TVAPQ of all patients, without a cutoff, there was an association of the variable with lifetime (p=0.013), i.e., for each increase of 10mL in TVAPQ there was an average increase of 2% in the risk of death. CONCLUSIONS: Although our results indicate that the TVAPQ could be considered alone as a predictor of poor prognosis regardless of the cutoff suggested in the literature, more studies are needed to replace the histology and staging by tumor size as best prognostic variable.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822015000100082&lng=en&tlng=enTumor de WilmsTamanho do órgãoQuimioterapiaPrognósticoAnálise de sobrevida |
| spellingShingle | Valentina Oliveira Provenzi Rafael Fabiano Machado Rosa Rosana Cardoso Manique Rosa Adriana Vial Roehe Pedro Paulo Albino dos Santos Fabrízia Rennó Sodero Faulhaber Ceres Andréia Vieira de Oliveira Paulo Ricardo Gazzola Zen Tumor size and prognosis in patients with Wilms tumor Revista Paulista de Pediatria Tumor de Wilms Tamanho do órgão Quimioterapia Prognóstico Análise de sobrevida |
| title | Tumor size and prognosis in patients with Wilms tumor |
| title_full | Tumor size and prognosis in patients with Wilms tumor |
| title_fullStr | Tumor size and prognosis in patients with Wilms tumor |
| title_full_unstemmed | Tumor size and prognosis in patients with Wilms tumor |
| title_short | Tumor size and prognosis in patients with Wilms tumor |
| title_sort | tumor size and prognosis in patients with wilms tumor |
| topic | Tumor de Wilms Tamanho do órgão Quimioterapia Prognóstico Análise de sobrevida |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822015000100082&lng=en&tlng=en |
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