Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing
Therapeutic targets of CRISPR-Cas can often not be accessed due to lack of carriers to deliver RNPs systematically. Here, the authors engineer modified lipid nanoparticles for delivery of gene editing proteins to specific tissues.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17029-3 |
| _version_ | 1818681694281007104 |
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| author | Tuo Wei Qiang Cheng Yi-Li Min Eric N. Olson Daniel J. Siegwart |
| author_facet | Tuo Wei Qiang Cheng Yi-Li Min Eric N. Olson Daniel J. Siegwart |
| author_sort | Tuo Wei |
| collection | DOAJ |
| description | Therapeutic targets of CRISPR-Cas can often not be accessed due to lack of carriers to deliver RNPs systematically. Here, the authors engineer modified lipid nanoparticles for delivery of gene editing proteins to specific tissues. |
| first_indexed | 2024-12-17T10:07:01Z |
| format | Article |
| id | doaj.art-643f6e049bbd4fa2a9c4925cf329f370 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:07:01Z |
| publishDate | 2020-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-643f6e049bbd4fa2a9c4925cf329f3702022-12-21T21:53:08ZengNature PortfolioNature Communications2041-17232020-06-0111111210.1038/s41467-020-17029-3Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editingTuo Wei0Qiang Cheng1Yi-Li Min2Eric N. Olson3Daniel J. Siegwart4Department of Biochemistry, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical CenterDepartment of Biochemistry, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical CenterDepartment of Molecular Biology, Hamon Center for Regenerative Science and Medicine, The University of Texas Southwestern Medical CenterDepartment of Molecular Biology, Hamon Center for Regenerative Science and Medicine, The University of Texas Southwestern Medical CenterDepartment of Biochemistry, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical CenterTherapeutic targets of CRISPR-Cas can often not be accessed due to lack of carriers to deliver RNPs systematically. Here, the authors engineer modified lipid nanoparticles for delivery of gene editing proteins to specific tissues.https://doi.org/10.1038/s41467-020-17029-3 |
| spellingShingle | Tuo Wei Qiang Cheng Yi-Li Min Eric N. Olson Daniel J. Siegwart Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing Nature Communications |
| title | Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing |
| title_full | Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing |
| title_fullStr | Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing |
| title_full_unstemmed | Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing |
| title_short | Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing |
| title_sort | systemic nanoparticle delivery of crispr cas9 ribonucleoproteins for effective tissue specific genome editing |
| url | https://doi.org/10.1038/s41467-020-17029-3 |
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