Defining the Relative Role of Insulin Clearance in Early Dysglycemia in Relation to Insulin Sensitivity and Insulin Secretion: The Microbiome and Insulin Longitudinal Evaluation Study (MILES)
Insulin resistance and insufficient insulin secretion are well-recognized contributors to type 2 diabetes. A potential role of reduced insulin clearance has been suggested, but few studies have investigated the contribution of insulin clearance while simultaneously examining decreased insulin sensit...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/11/7/420 |
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| author | Alexis C. Wood Elizabeth T. Jensen Alain G. Bertoni Gautam Ramesh Stephen S. Rich Jerome I. Rotter Yii-Der I. Chen Mark O. Goodarzi |
| author_facet | Alexis C. Wood Elizabeth T. Jensen Alain G. Bertoni Gautam Ramesh Stephen S. Rich Jerome I. Rotter Yii-Der I. Chen Mark O. Goodarzi |
| author_sort | Alexis C. Wood |
| collection | DOAJ |
| description | Insulin resistance and insufficient insulin secretion are well-recognized contributors to type 2 diabetes. A potential role of reduced insulin clearance has been suggested, but few studies have investigated the contribution of insulin clearance while simultaneously examining decreased insulin sensitivity and secretion. The goal of this study was to conduct such an investigation in a cohort of 353 non-Hispanic White and African American individuals recruited in the Microbiome and Insulin Longitudinal Evaluation Study (MILES). Participants underwent oral glucose tolerance tests from which insulin sensitivity, insulin secretion, insulin clearance, and disposition index were calculated. Regression models examined the individual and joint contributions of these traits to early dysglycemia (prediabetes or newly diagnosed diabetes). In separate models, reduced insulin sensitivity, reduced disposition index, and reduced insulin clearance were associated with dysglycemia. In a joint model, only insulin resistance and reduced insulin secretion were associated with dysglycemia. Models with insulin sensitivity, disposition index, or three insulin traits had the highest discriminative value for dysglycemia (area under the receiver operating characteristics curve of 0.82 to 0.89). These results suggest that in the race groups studied, insulin resistance and compromised insulin secretion are the main independent underlying defects leading to early dysglycemia. |
| first_indexed | 2024-03-10T10:01:36Z |
| format | Article |
| id | doaj.art-64430b88d0c94b1fa9e698660b865415 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T10:01:36Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-64430b88d0c94b1fa9e698660b8654152023-11-22T01:51:18ZengMDPI AGMetabolites2218-19892021-06-0111742010.3390/metabo11070420Defining the Relative Role of Insulin Clearance in Early Dysglycemia in Relation to Insulin Sensitivity and Insulin Secretion: The Microbiome and Insulin Longitudinal Evaluation Study (MILES)Alexis C. Wood0Elizabeth T. Jensen1Alain G. Bertoni2Gautam Ramesh3Stephen S. Rich4Jerome I. Rotter5Yii-Der I. Chen6Mark O. Goodarzi7USDA/ARS Children’s Nutrition Research Center, Baylor College of Medicine, Houston, TX 77030, USADepartment of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC 27101, USADepartment of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC 27101, USASchool of Medicine, University of California, La Jolla, San Diego, CA 92093, USACenter for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USAInstitute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA 90502, USAInstitute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA 90502, USADivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USAInsulin resistance and insufficient insulin secretion are well-recognized contributors to type 2 diabetes. A potential role of reduced insulin clearance has been suggested, but few studies have investigated the contribution of insulin clearance while simultaneously examining decreased insulin sensitivity and secretion. The goal of this study was to conduct such an investigation in a cohort of 353 non-Hispanic White and African American individuals recruited in the Microbiome and Insulin Longitudinal Evaluation Study (MILES). Participants underwent oral glucose tolerance tests from which insulin sensitivity, insulin secretion, insulin clearance, and disposition index were calculated. Regression models examined the individual and joint contributions of these traits to early dysglycemia (prediabetes or newly diagnosed diabetes). In separate models, reduced insulin sensitivity, reduced disposition index, and reduced insulin clearance were associated with dysglycemia. In a joint model, only insulin resistance and reduced insulin secretion were associated with dysglycemia. Models with insulin sensitivity, disposition index, or three insulin traits had the highest discriminative value for dysglycemia (area under the receiver operating characteristics curve of 0.82 to 0.89). These results suggest that in the race groups studied, insulin resistance and compromised insulin secretion are the main independent underlying defects leading to early dysglycemia.https://www.mdpi.com/2218-1989/11/7/420insulin sensitivityinsulin secretioninsulin clearancedisposition indexprediabetesdiabetes |
| spellingShingle | Alexis C. Wood Elizabeth T. Jensen Alain G. Bertoni Gautam Ramesh Stephen S. Rich Jerome I. Rotter Yii-Der I. Chen Mark O. Goodarzi Defining the Relative Role of Insulin Clearance in Early Dysglycemia in Relation to Insulin Sensitivity and Insulin Secretion: The Microbiome and Insulin Longitudinal Evaluation Study (MILES) Metabolites insulin sensitivity insulin secretion insulin clearance disposition index prediabetes diabetes |
| title | Defining the Relative Role of Insulin Clearance in Early Dysglycemia in Relation to Insulin Sensitivity and Insulin Secretion: The Microbiome and Insulin Longitudinal Evaluation Study (MILES) |
| title_full | Defining the Relative Role of Insulin Clearance in Early Dysglycemia in Relation to Insulin Sensitivity and Insulin Secretion: The Microbiome and Insulin Longitudinal Evaluation Study (MILES) |
| title_fullStr | Defining the Relative Role of Insulin Clearance in Early Dysglycemia in Relation to Insulin Sensitivity and Insulin Secretion: The Microbiome and Insulin Longitudinal Evaluation Study (MILES) |
| title_full_unstemmed | Defining the Relative Role of Insulin Clearance in Early Dysglycemia in Relation to Insulin Sensitivity and Insulin Secretion: The Microbiome and Insulin Longitudinal Evaluation Study (MILES) |
| title_short | Defining the Relative Role of Insulin Clearance in Early Dysglycemia in Relation to Insulin Sensitivity and Insulin Secretion: The Microbiome and Insulin Longitudinal Evaluation Study (MILES) |
| title_sort | defining the relative role of insulin clearance in early dysglycemia in relation to insulin sensitivity and insulin secretion the microbiome and insulin longitudinal evaluation study miles |
| topic | insulin sensitivity insulin secretion insulin clearance disposition index prediabetes diabetes |
| url | https://www.mdpi.com/2218-1989/11/7/420 |
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