Extracellular vesicles as potential biomarkers and therapeutic approaches in autoimmune diseases
Abstract Extracellular vesicles are heterogeneous populations of naturally occurring secreted small vesicles. EVs function as signaling platforms to facilitate intracellular communication, which indicates the physiological or pathophysiological conditions of cells or tissues. Considering that EVs ca...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-11-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12967-020-02609-0 |
| _version_ | 1819158880617234432 |
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| author | Kaiyuan Xu Qin Liu Kaihui Wu Liu Liu Maomao Zhao Hui Yang Xiang Wang Wenmei Wang |
| author_facet | Kaiyuan Xu Qin Liu Kaihui Wu Liu Liu Maomao Zhao Hui Yang Xiang Wang Wenmei Wang |
| author_sort | Kaiyuan Xu |
| collection | DOAJ |
| description | Abstract Extracellular vesicles are heterogeneous populations of naturally occurring secreted small vesicles. EVs function as signaling platforms to facilitate intracellular communication, which indicates the physiological or pathophysiological conditions of cells or tissues. Considering that EVs can be isolated from most body fluids and that molecular constituents could be reprogrammed according to the physiological status of the secreting cells, EVs are regarded as novel diagnostic and prognostic biomarkers for many diseases. The ability to protect encapsulated molecules from degradation in body fluids suggests the potential of EVs as biological medicines or drug delivery systems. This article focuses on the EV-associated biomarkers and therapeutic approaches in autoimmune diseases. |
| first_indexed | 2024-12-22T16:31:41Z |
| format | Article |
| id | doaj.art-644356e96a4b413f90ec24095b5ad5e8 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-12-22T16:31:41Z |
| publishDate | 2020-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-644356e96a4b413f90ec24095b5ad5e82022-12-21T18:20:03ZengBMCJournal of Translational Medicine1479-58762020-11-011811810.1186/s12967-020-02609-0Extracellular vesicles as potential biomarkers and therapeutic approaches in autoimmune diseasesKaiyuan Xu0Qin Liu1Kaihui Wu2Liu Liu3Maomao Zhao4Hui Yang5Xiang Wang6Wenmei Wang7Department of Oral Medicine, Nanjing Stomatological Hospital, Medical School of Nanjing UniversityDepartment of Oral Medicine, Nanjing Stomatological Hospital, Medical School of Nanjing UniversityDepartment of Oral Medicine, Nanjing Stomatological Hospital, Medical School of Nanjing UniversityDepartment of Oral Medicine, Nanjing Stomatological Hospital, Medical School of Nanjing UniversityDepartment of Oral Medicine, Nanjing Stomatological Hospital, Medical School of Nanjing UniversityDepartment of Oral Medicine, Nanjing Stomatological Hospital, Medical School of Nanjing UniversityDepartment of Oral Medicine, Nanjing Stomatological Hospital, Medical School of Nanjing UniversityDepartment of Oral Medicine, Nanjing Stomatological Hospital, Medical School of Nanjing UniversityAbstract Extracellular vesicles are heterogeneous populations of naturally occurring secreted small vesicles. EVs function as signaling platforms to facilitate intracellular communication, which indicates the physiological or pathophysiological conditions of cells or tissues. Considering that EVs can be isolated from most body fluids and that molecular constituents could be reprogrammed according to the physiological status of the secreting cells, EVs are regarded as novel diagnostic and prognostic biomarkers for many diseases. The ability to protect encapsulated molecules from degradation in body fluids suggests the potential of EVs as biological medicines or drug delivery systems. This article focuses on the EV-associated biomarkers and therapeutic approaches in autoimmune diseases.http://link.springer.com/article/10.1186/s12967-020-02609-0AutoimmunityBiomarkerTherapyExtracellular vesicleExosomesMicroRNA |
| spellingShingle | Kaiyuan Xu Qin Liu Kaihui Wu Liu Liu Maomao Zhao Hui Yang Xiang Wang Wenmei Wang Extracellular vesicles as potential biomarkers and therapeutic approaches in autoimmune diseases Journal of Translational Medicine Autoimmunity Biomarker Therapy Extracellular vesicle Exosomes MicroRNA |
| title | Extracellular vesicles as potential biomarkers and therapeutic approaches in autoimmune diseases |
| title_full | Extracellular vesicles as potential biomarkers and therapeutic approaches in autoimmune diseases |
| title_fullStr | Extracellular vesicles as potential biomarkers and therapeutic approaches in autoimmune diseases |
| title_full_unstemmed | Extracellular vesicles as potential biomarkers and therapeutic approaches in autoimmune diseases |
| title_short | Extracellular vesicles as potential biomarkers and therapeutic approaches in autoimmune diseases |
| title_sort | extracellular vesicles as potential biomarkers and therapeutic approaches in autoimmune diseases |
| topic | Autoimmunity Biomarker Therapy Extracellular vesicle Exosomes MicroRNA |
| url | http://link.springer.com/article/10.1186/s12967-020-02609-0 |
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