Polyphenols in Health and Disease: Gut Microbiota, Bioaccessibility, and Bioavailability
Polyphenolic compounds (PC) are among the most abundant secondary metabolites in nature. They are widely distributed in the world and can be found in fruits, cereals, tea, coffee, and beverages. Due to their structural diversity, polyphenols have many different properties and biological effects. The...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
|
| Series: | Compounds |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-6918/3/1/5 |
| _version_ | 1797612547651665920 |
|---|---|
| author | Joaquim Bié Bruno Sepodes Pedro C. B. Fernandes Maria H. L. Ribeiro |
| author_facet | Joaquim Bié Bruno Sepodes Pedro C. B. Fernandes Maria H. L. Ribeiro |
| author_sort | Joaquim Bié |
| collection | DOAJ |
| description | Polyphenolic compounds (PC) are among the most abundant secondary metabolites in nature. They are widely distributed in the world and can be found in fruits, cereals, tea, coffee, and beverages. Due to their structural diversity, polyphenols have many different properties and biological effects. They are resistant to the acid of the gastric tract, and very few are hydrolysed or absorbed in the stomach. Significant portions of ingested polyphenols reach the large intestine and interact with the local bacteria, the so-called gut microbiota. Epidemiological studies confirm that moderate and prolonged intake of foods rich in polyphenols could prevent the development of cancer and chronic diseases, such as cardiovascular, neurodegenerative, type 2 diabetes, and obesity. The current work aims to provide an updated overview on the nature and occurrence of polyphenols, quantification methods, bioaccessibility and bioavailability, and impact on human health, namely through interactions with the gut microbiota. |
| first_indexed | 2024-03-11T06:43:44Z |
| format | Article |
| id | doaj.art-64451c1cd90d47f397f62449917fbaff |
| institution | Directory Open Access Journal |
| issn | 2673-6918 |
| language | English |
| last_indexed | 2024-03-11T06:43:44Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Compounds |
| spelling | doaj.art-64451c1cd90d47f397f62449917fbaff2023-11-17T10:25:42ZengMDPI AGCompounds2673-69182023-01-0131407210.3390/compounds3010005Polyphenols in Health and Disease: Gut Microbiota, Bioaccessibility, and BioavailabilityJoaquim Bié0Bruno Sepodes1Pedro C. B. Fernandes2Maria H. L. Ribeiro3Research Institute for Medicines (i-Med), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, PortugalResearch Institute for Medicines (i-Med), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, PortugaliBB—Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, PortugalResearch Institute for Medicines (i-Med), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, PortugalPolyphenolic compounds (PC) are among the most abundant secondary metabolites in nature. They are widely distributed in the world and can be found in fruits, cereals, tea, coffee, and beverages. Due to their structural diversity, polyphenols have many different properties and biological effects. They are resistant to the acid of the gastric tract, and very few are hydrolysed or absorbed in the stomach. Significant portions of ingested polyphenols reach the large intestine and interact with the local bacteria, the so-called gut microbiota. Epidemiological studies confirm that moderate and prolonged intake of foods rich in polyphenols could prevent the development of cancer and chronic diseases, such as cardiovascular, neurodegenerative, type 2 diabetes, and obesity. The current work aims to provide an updated overview on the nature and occurrence of polyphenols, quantification methods, bioaccessibility and bioavailability, and impact on human health, namely through interactions with the gut microbiota.https://www.mdpi.com/2673-6918/3/1/5polyphenolsgut microbiotabioactivitybioavailabilityflavonoids |
| spellingShingle | Joaquim Bié Bruno Sepodes Pedro C. B. Fernandes Maria H. L. Ribeiro Polyphenols in Health and Disease: Gut Microbiota, Bioaccessibility, and Bioavailability Compounds polyphenols gut microbiota bioactivity bioavailability flavonoids |
| title | Polyphenols in Health and Disease: Gut Microbiota, Bioaccessibility, and Bioavailability |
| title_full | Polyphenols in Health and Disease: Gut Microbiota, Bioaccessibility, and Bioavailability |
| title_fullStr | Polyphenols in Health and Disease: Gut Microbiota, Bioaccessibility, and Bioavailability |
| title_full_unstemmed | Polyphenols in Health and Disease: Gut Microbiota, Bioaccessibility, and Bioavailability |
| title_short | Polyphenols in Health and Disease: Gut Microbiota, Bioaccessibility, and Bioavailability |
| title_sort | polyphenols in health and disease gut microbiota bioaccessibility and bioavailability |
| topic | polyphenols gut microbiota bioactivity bioavailability flavonoids |
| url | https://www.mdpi.com/2673-6918/3/1/5 |
| work_keys_str_mv | AT joaquimbie polyphenolsinhealthanddiseasegutmicrobiotabioaccessibilityandbioavailability AT brunosepodes polyphenolsinhealthanddiseasegutmicrobiotabioaccessibilityandbioavailability AT pedrocbfernandes polyphenolsinhealthanddiseasegutmicrobiotabioaccessibilityandbioavailability AT mariahlribeiro polyphenolsinhealthanddiseasegutmicrobiotabioaccessibilityandbioavailability |