Dynamics and mechanisms of clonal expansion of HIV-1-infected cells in a humanized mouse model

Dynamics and mechanisms of clonal expansion of HIV-1-infected cells in a humanized mouse model

Abstract Combination anti-retroviral therapy (cART) has drastically improved the clinical outcome of HIV-1 infection. Nonetheless, despite effective cART, HIV-1 persists indefinitely in infected individuals. Clonal expansion of HIV-1-infected cells in peripheral blood has been reported recently. cAR...

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Bibliographic Details
Main Authors: Yorifumi Satou, Hiroo Katsuya, Asami Fukuda, Naoko Misawa, Jumpei Ito, Yoshikazu Uchiyama, Paola Miyazato, Saiful Islam, Ariberto Fassati, Anat Melamed, Charles R. M. Bangham, Yoshio Koyanagi, Kei Sato
Format: Article
Language:English
Published: Nature Portfolio 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-07307-4

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