S100A8 and S100A9 are elevated in chronically threatened ischemic limb muscle and induce ischemic mitochondrial pathology in mice

S100A8 and S100A9 are elevated in chronically threatened ischemic limb muscle and induce ischemic mitochondrial pathology in mice

Objective: The objective of the present study was to determine whether elevated levels of S100A8 and S100A9 (S100A8/A9) alarmins contribute to ischemic limb pathology. Methods: Gastrocnemius muscle was collected from control patients without peripheral arterial disease (PAD; n = 14) and patients wit...

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Bibliographic Details
Main Authors: Zachary R. Salyers, MS, Vinicius Mariani, MS, Nicholas Balestrieri, MS, Ravi A. Kumar, MS, Nicholas A. Vugman, Trace Thome, MS, Katelyn R. Villani, MS, Scott A. Berceli, MD, PhD, Salvatore T. Scali, MD, Georgios Vasilakos, PhD, Terence E. Ryan, PhD
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:JVS - Vascular Science
Subjects:
Inflammation
Mitochondria
Peripheral artery disease
Vascular disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2666350322000074

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