A B-cell actomyosin arc network couples integrin co-stimulation to mechanical force-dependent immune synapse formation

A B-cell actomyosin arc network couples integrin co-stimulation to mechanical force-dependent immune synapse formation

B-cell activation and immune synapse (IS) formation with membrane-bound antigens are actin-dependent processes that scale positively with the strength of antigen-induced signals. Importantly, ligating the B-cell integrin, LFA-1, with ICAM-1 promotes IS formation when antigen is limiting. Whether the...

Full description

Bibliographic Details
Main Authors: Jia C Wang, Yang-In Yim, Xufeng Wu, Valentin Jaumouille, Andrew Cameron, Clare M Waterman, John H Kehrl, John A Hammer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-04-01
Series:eLife
Subjects:
actin
B cell
immune synapse
integrin
myosin
Online Access:https://elifesciences.org/articles/72805

Internet

https://elifesciences.org/articles/72805

Similar Items