ENDOBRONCHIAL PHOTODYNAMIC THERAPY UNDER FLUORESCENCE CONTROL: PHOTODYNAMIC THERANOSTICS
One of the disadvantages of photodynamic therapy is impossibility to specify the method according to biological features of malignant tumor such as a degree of blood supply, accumulation of photosensibilizator in tumorous tissue, proliferative activity and etc. The authors aimed to develop a mode of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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Pavlov First Saint Petersburg State Medical University
2016-10-01
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| Series: | Вестник хирургии имени И.И. Грекова |
| Subjects: | |
| Online Access: | https://www.vestnik-grekova.ru/jour/article/view/338 |
| _version_ | 1826962675649740800 |
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| author | A. L. Akopov A. A. Rusanov G. V. Papayan N. V. Kazakov A. V. Gerasin |
| author_facet | A. L. Akopov A. A. Rusanov G. V. Papayan N. V. Kazakov A. V. Gerasin |
| author_sort | A. L. Akopov |
| collection | DOAJ |
| description | One of the disadvantages of photodynamic therapy is impossibility to specify the method according to biological features of malignant tumor such as a degree of blood supply, accumulation of photosensibilizator in tumorous tissue, proliferative activity and etc. The authors aimed to develop a mode of individualization of endobronchial photodynamic therapy of central non-small cell carcinoma of lung and assessment of method efficacy. The suggested method is based on fluorescent diagnostics of degree of accumulation of photosensibilizator in timorous tissue and the rate of its expenditure in process of performing of photodynamic therapy. There was made a comparison of parameters of methods and results of photodynamic therapy in 2 randomized groups. Each group consisted of 45 patients. The research method was applied in the main group and the standard method was used in the comparison group. It was found that the research method allowed significant reduction of duration of irradiation compared with conventional method (at the average from 690±65sec to 470±45sec, p=0,02), though the treatment results were the same. The suggested method allowed separation of group of patients with absence of fluorescence of timorous tissue. Performance of photodynamic therapy is unreasonable for these patients. |
| first_indexed | 2024-04-10T02:22:40Z |
| format | Article |
| id | doaj.art-64496b0a468744e2b46d00e1f761966b |
| institution | Directory Open Access Journal |
| issn | 0042-4625 |
| language | Russian |
| last_indexed | 2025-02-18T02:19:58Z |
| publishDate | 2016-10-01 |
| publisher | Pavlov First Saint Petersburg State Medical University |
| record_format | Article |
| series | Вестник хирургии имени И.И. Грекова |
| spelling | doaj.art-64496b0a468744e2b46d00e1f761966b2024-11-26T10:43:45ZrusPavlov First Saint Petersburg State Medical UniversityВестник хирургии имени И.И. Грекова0042-46252016-10-011755263110.24884/0042-4625-2016-175-5-26-31337ENDOBRONCHIAL PHOTODYNAMIC THERAPY UNDER FLUORESCENCE CONTROL: PHOTODYNAMIC THERANOSTICSA. L. Akopov0A. A. Rusanov1G. V. Papayan2N. V. Kazakov3A. V. Gerasin4I. P.Pavlov First Saint-Petersburg State Medical UniversityI. P.Pavlov First Saint-Petersburg State Medical UniversityI. P.Pavlov First Saint-Petersburg State Medical UniversityI. P.Pavlov First Saint-Petersburg State Medical UniversityI. P.Pavlov First Saint-Petersburg State Medical UniversityOne of the disadvantages of photodynamic therapy is impossibility to specify the method according to biological features of malignant tumor such as a degree of blood supply, accumulation of photosensibilizator in tumorous tissue, proliferative activity and etc. The authors aimed to develop a mode of individualization of endobronchial photodynamic therapy of central non-small cell carcinoma of lung and assessment of method efficacy. The suggested method is based on fluorescent diagnostics of degree of accumulation of photosensibilizator in timorous tissue and the rate of its expenditure in process of performing of photodynamic therapy. There was made a comparison of parameters of methods and results of photodynamic therapy in 2 randomized groups. Each group consisted of 45 patients. The research method was applied in the main group and the standard method was used in the comparison group. It was found that the research method allowed significant reduction of duration of irradiation compared with conventional method (at the average from 690±65sec to 470±45sec, p=0,02), though the treatment results were the same. The suggested method allowed separation of group of patients with absence of fluorescence of timorous tissue. Performance of photodynamic therapy is unreasonable for these patients.https://www.vestnik-grekova.ru/jour/article/view/338non-small cell carcinoma of lungphotodynamic therapyendobrochialfluorescence |
| spellingShingle | A. L. Akopov A. A. Rusanov G. V. Papayan N. V. Kazakov A. V. Gerasin ENDOBRONCHIAL PHOTODYNAMIC THERAPY UNDER FLUORESCENCE CONTROL: PHOTODYNAMIC THERANOSTICS Вестник хирургии имени И.И. Грекова non-small cell carcinoma of lung photodynamic therapy endobrochial fluorescence |
| title | ENDOBRONCHIAL PHOTODYNAMIC THERAPY UNDER FLUORESCENCE CONTROL: PHOTODYNAMIC THERANOSTICS |
| title_full | ENDOBRONCHIAL PHOTODYNAMIC THERAPY UNDER FLUORESCENCE CONTROL: PHOTODYNAMIC THERANOSTICS |
| title_fullStr | ENDOBRONCHIAL PHOTODYNAMIC THERAPY UNDER FLUORESCENCE CONTROL: PHOTODYNAMIC THERANOSTICS |
| title_full_unstemmed | ENDOBRONCHIAL PHOTODYNAMIC THERAPY UNDER FLUORESCENCE CONTROL: PHOTODYNAMIC THERANOSTICS |
| title_short | ENDOBRONCHIAL PHOTODYNAMIC THERAPY UNDER FLUORESCENCE CONTROL: PHOTODYNAMIC THERANOSTICS |
| title_sort | endobronchial photodynamic therapy under fluorescence control photodynamic theranostics |
| topic | non-small cell carcinoma of lung photodynamic therapy endobrochial fluorescence |
| url | https://www.vestnik-grekova.ru/jour/article/view/338 |
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