Walking and taking vitamin C alleviates oxidative stress and inflammation in overweight students, even in the short-term
ObjectiveObese or overweight is a risk factor for some chronic diseases, and oxidative stress and inflammation may be one of the molecular mechanisms leading to the persistence of these chronic diseases. Discovering interventions to alleviate oxidative stress and inflammation in the overweight/obese...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.1024864/full |
| _version_ | 1797997346014887936 |
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| author | Qian Zhang Qian Zhang Miao Guo Tianyi Chen Huizhi Cheng Qianwen Yang Zhuohui Zhao Rong She Xiaoyan Yang Wen Xiao Xu Yang Xu Yang Lijuan Li Lijuan Li |
| author_facet | Qian Zhang Qian Zhang Miao Guo Tianyi Chen Huizhi Cheng Qianwen Yang Zhuohui Zhao Rong She Xiaoyan Yang Wen Xiao Xu Yang Xu Yang Lijuan Li Lijuan Li |
| author_sort | Qian Zhang |
| collection | DOAJ |
| description | ObjectiveObese or overweight is a risk factor for some chronic diseases, and oxidative stress and inflammation may be one of the molecular mechanisms leading to the persistence of these chronic diseases. Discovering interventions to alleviate oxidative stress and inflammation in the overweight/obese population, is very important for public health and health education.MethodsA two-week panel intervention study (Run 0-Run 1-Run 2) was conducted. The subjects were 77 overweight/obese undergraduates attending Dali University, with a BMI>24 kg/m2. The physical indices measured at the end of each run included BMI, waist circumference, serum ROS, TNF-α, IL-1β and urinary 8-OHdG. Students were allocated to one of four intervention groups: No intervention (control); walking; taking vitamin C; and walking + taking vitamin C.ResultsThe results demonstrated (1) Walking significantly alleviated ROS levels, and this was consistent in Run 1 and Run 2; (2) During Run1, all three intervention modes reduced levels of 8-OHdG, but there was a statistically insignificant increase during Run 2; (3) No alleviating effects of the three intervention modes on TNF-α levels during Run 1 and Run 2 were observed; (4) The alleviating effects of the three intervention modes on IL-1β levels during Run 1 and Run 2 were clear.ConclusionWalking and taking vitamin C can reduce levels of ROS, 8-OHdG and IL-1β, but not TNF-α, in overweight/obese participants. These interventions may become potential preventive measures for the overweight against obese-induced oxidative stress and inflammation. |
| first_indexed | 2024-04-11T10:31:18Z |
| format | Article |
| id | doaj.art-6449f553f9c84238aed25c39746fd809 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-11T10:31:18Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-6449f553f9c84238aed25c39746fd8092022-12-22T04:29:25ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-10-011010.3389/fpubh.2022.10248641024864Walking and taking vitamin C alleviates oxidative stress and inflammation in overweight students, even in the short-termQian Zhang0Qian Zhang1Miao Guo2Tianyi Chen3Huizhi Cheng4Qianwen Yang5Zhuohui Zhao6Rong She7Xiaoyan Yang8Wen Xiao9Xu Yang10Xu Yang11Lijuan Li12Lijuan Li13Institute of Natural Antioxidants and Antioxidant Inflammation, Dali University, Dali, ChinaSchool of Public Health, Dali University, Dali, ChinaJoint International Research Laboratory of Green Buildings and Built Environments (Ministry of Education), Chongqing University, Chongqing, ChinaDepartment of Environmental Health, School of Public Health, Fudan University, Shanghai, ChinaSchool of Public Health, Dali University, Dali, ChinaSchool of Public Health, Dali University, Dali, ChinaDepartment of Environmental Health, School of Public Health, Fudan University, Shanghai, ChinaInstitute of Natural Antioxidants and Antioxidant Inflammation, Dali University, Dali, ChinaInstitute of Natural Antioxidants and Antioxidant Inflammation, Dali University, Dali, ChinaInstitute of Eastern-Himalaya Biodiversity Research, Dali University, Dali, ChinaInstitute of Natural Antioxidants and Antioxidant Inflammation, Dali University, Dali, ChinaXianning Medical College, Hubei University of Science and Technology, Hubei, ChinaInstitute of Natural Antioxidants and Antioxidant Inflammation, Dali University, Dali, ChinaSchool of Public Health, Dali University, Dali, ChinaObjectiveObese or overweight is a risk factor for some chronic diseases, and oxidative stress and inflammation may be one of the molecular mechanisms leading to the persistence of these chronic diseases. Discovering interventions to alleviate oxidative stress and inflammation in the overweight/obese population, is very important for public health and health education.MethodsA two-week panel intervention study (Run 0-Run 1-Run 2) was conducted. The subjects were 77 overweight/obese undergraduates attending Dali University, with a BMI>24 kg/m2. The physical indices measured at the end of each run included BMI, waist circumference, serum ROS, TNF-α, IL-1β and urinary 8-OHdG. Students were allocated to one of four intervention groups: No intervention (control); walking; taking vitamin C; and walking + taking vitamin C.ResultsThe results demonstrated (1) Walking significantly alleviated ROS levels, and this was consistent in Run 1 and Run 2; (2) During Run1, all three intervention modes reduced levels of 8-OHdG, but there was a statistically insignificant increase during Run 2; (3) No alleviating effects of the three intervention modes on TNF-α levels during Run 1 and Run 2 were observed; (4) The alleviating effects of the three intervention modes on IL-1β levels during Run 1 and Run 2 were clear.ConclusionWalking and taking vitamin C can reduce levels of ROS, 8-OHdG and IL-1β, but not TNF-α, in overweight/obese participants. These interventions may become potential preventive measures for the overweight against obese-induced oxidative stress and inflammation.https://www.frontiersin.org/articles/10.3389/fpubh.2022.1024864/fulloverweight/obesityoxidative stressinflammatory cytokinealleviationwalkingvitamin C |
| spellingShingle | Qian Zhang Qian Zhang Miao Guo Tianyi Chen Huizhi Cheng Qianwen Yang Zhuohui Zhao Rong She Xiaoyan Yang Wen Xiao Xu Yang Xu Yang Lijuan Li Lijuan Li Walking and taking vitamin C alleviates oxidative stress and inflammation in overweight students, even in the short-term Frontiers in Public Health overweight/obesity oxidative stress inflammatory cytokine alleviation walking vitamin C |
| title | Walking and taking vitamin C alleviates oxidative stress and inflammation in overweight students, even in the short-term |
| title_full | Walking and taking vitamin C alleviates oxidative stress and inflammation in overweight students, even in the short-term |
| title_fullStr | Walking and taking vitamin C alleviates oxidative stress and inflammation in overweight students, even in the short-term |
| title_full_unstemmed | Walking and taking vitamin C alleviates oxidative stress and inflammation in overweight students, even in the short-term |
| title_short | Walking and taking vitamin C alleviates oxidative stress and inflammation in overweight students, even in the short-term |
| title_sort | walking and taking vitamin c alleviates oxidative stress and inflammation in overweight students even in the short term |
| topic | overweight/obesity oxidative stress inflammatory cytokine alleviation walking vitamin C |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.1024864/full |
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