Quantitative Phosphoproteome Analysis of Clostridioides difficile Toxin B Treated Human Epithelial Cells

Quantitative Phosphoproteome Analysis of Clostridioides difficile Toxin B Treated Human Epithelial Cells

The large clostridial glucosylating toxin B (TcdB) is a major virulence factor of the nosocomial pathogen Clostridioides difficile. TcdB inhibits small GTPases by glucosylation leading to impaired downstream signaling. TcdB also possesses a glucosyltransferase independent effect described as pyknosi...

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Bibliographic Details
Main Authors: Johannes Junemann, Ingo Just, Ralf Gerhard, Andreas Pich
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Microbiology
Subjects:
Clostridioides difficile
phosphoproteome
shotgun proteomics
small GTPases
TcdB
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.03083/full

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