The Role of the Endocannabinoid System in Binge Eating Disorder
Eating disorders are multifactorial disorders that involve maladaptive feeding behaviors. Binge eating disorder (BED), the most prevalent of these in both men and women, is characterized by recurrent episodes of eating large amounts of food in a short period of time, with a subjective loss of contro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/11/9574 |
| _version_ | 1797597398129704960 |
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| author | Romain Bourdy Katia Befort |
| author_facet | Romain Bourdy Katia Befort |
| author_sort | Romain Bourdy |
| collection | DOAJ |
| description | Eating disorders are multifactorial disorders that involve maladaptive feeding behaviors. Binge eating disorder (BED), the most prevalent of these in both men and women, is characterized by recurrent episodes of eating large amounts of food in a short period of time, with a subjective loss of control over eating behavior. BED modulates the brain reward circuit in humans and animal models, which involves the dynamic regulation of the dopamine circuitry. The endocannabinoid system plays a major role in the regulation of food intake, both centrally and in the periphery. Pharmacological approaches together with research using genetically modified animals have strongly highlighted a predominant role of the endocannabinoid system in feeding behaviors, with the specific modulation of addictive-like eating behaviors. The purpose of the present review is to summarize our current knowledge on the neurobiology of BED in humans and animal models and to highlight the specific role of the endocannabinoid system in the development and maintenance of BED. A proposed model for a better understanding of the underlying mechanisms involving the endocannabinoid system is discussed. Future research will be necessary to develop more specific treatment strategies to reduce BED symptoms. |
| first_indexed | 2024-03-11T03:04:38Z |
| format | Article |
| id | doaj.art-644d3783752044909ec54236d005785a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T03:04:38Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-644d3783752044909ec54236d005785a2023-11-18T08:00:58ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-05-012411957410.3390/ijms24119574The Role of the Endocannabinoid System in Binge Eating DisorderRomain Bourdy0Katia Befort1Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA), Université de Strasbourg, UMR7364, CNRS, 12 Rue Goethe, 67000 Strasbourg, FranceLaboratoire de Neurosciences Cognitives et Adaptatives (LNCA), Université de Strasbourg, UMR7364, CNRS, 12 Rue Goethe, 67000 Strasbourg, FranceEating disorders are multifactorial disorders that involve maladaptive feeding behaviors. Binge eating disorder (BED), the most prevalent of these in both men and women, is characterized by recurrent episodes of eating large amounts of food in a short period of time, with a subjective loss of control over eating behavior. BED modulates the brain reward circuit in humans and animal models, which involves the dynamic regulation of the dopamine circuitry. The endocannabinoid system plays a major role in the regulation of food intake, both centrally and in the periphery. Pharmacological approaches together with research using genetically modified animals have strongly highlighted a predominant role of the endocannabinoid system in feeding behaviors, with the specific modulation of addictive-like eating behaviors. The purpose of the present review is to summarize our current knowledge on the neurobiology of BED in humans and animal models and to highlight the specific role of the endocannabinoid system in the development and maintenance of BED. A proposed model for a better understanding of the underlying mechanisms involving the endocannabinoid system is discussed. Future research will be necessary to develop more specific treatment strategies to reduce BED symptoms.https://www.mdpi.com/1422-0067/24/11/9574endocannabinoidseating disordersrewarddiet-induced obesitygenetically modified mice |
| spellingShingle | Romain Bourdy Katia Befort The Role of the Endocannabinoid System in Binge Eating Disorder International Journal of Molecular Sciences endocannabinoids eating disorders reward diet-induced obesity genetically modified mice |
| title | The Role of the Endocannabinoid System in Binge Eating Disorder |
| title_full | The Role of the Endocannabinoid System in Binge Eating Disorder |
| title_fullStr | The Role of the Endocannabinoid System in Binge Eating Disorder |
| title_full_unstemmed | The Role of the Endocannabinoid System in Binge Eating Disorder |
| title_short | The Role of the Endocannabinoid System in Binge Eating Disorder |
| title_sort | role of the endocannabinoid system in binge eating disorder |
| topic | endocannabinoids eating disorders reward diet-induced obesity genetically modified mice |
| url | https://www.mdpi.com/1422-0067/24/11/9574 |
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