Cannabinoids in traumatic brain injury and related neuropathologies: preclinical and clinical research on endogenous, plant-derived, and synthetic compounds
Abstract Traumatic brain injury is common, and often results in debilitating consequences. Even mild traumatic brain injury leaves approximately 20% of patients with symptoms that persist for months. Despite great clinical need there are currently no approved pharmaceutical interventions that improv...
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | Journal of Neuroinflammation |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12974-023-02734-9 |
| _version_ | 1797864016586997760 |
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| author | Brittney R. Lins Chidozie C. Anyaegbu Sarah C. Hellewell Melissa Papini Terence McGonigle Luca De Prato Matthew Shales Melinda Fitzgerald |
| author_facet | Brittney R. Lins Chidozie C. Anyaegbu Sarah C. Hellewell Melissa Papini Terence McGonigle Luca De Prato Matthew Shales Melinda Fitzgerald |
| author_sort | Brittney R. Lins |
| collection | DOAJ |
| description | Abstract Traumatic brain injury is common, and often results in debilitating consequences. Even mild traumatic brain injury leaves approximately 20% of patients with symptoms that persist for months. Despite great clinical need there are currently no approved pharmaceutical interventions that improve outcomes after traumatic brain injury. Increased understanding of the endocannabinoid system in health and disease has accompanied growing evidence for therapeutic benefits of Cannabis sativa. This has driven research of Cannabis’ active chemical constituents (phytocannabinoids), alongside endogenous and synthetic counterparts, collectively known as cannabinoids. Also of therapeutic interest are other Cannabis constituents, such as terpenes. Cannabinoids interact with neurons, microglia, and astrocytes, and exert anti-inflammatory and neuroprotective effects which are highly desirable for the management of traumatic brain injury. In this review, we comprehensively appraised the relevant scientific literature, where major and minor phytocannabinoids, terpenes, synthetic cannabinoids, and endogenous cannabinoids were assessed in TBI, or other neurological conditions with pathology and symptomology relevant to TBI, as well as recent studies in preclinical TBI models and clinical TBI populations. |
| first_indexed | 2024-04-09T22:44:49Z |
| format | Article |
| id | doaj.art-644dd3a87c694826842c19ca5d8a5e5e |
| institution | Directory Open Access Journal |
| issn | 1742-2094 |
| language | English |
| last_indexed | 2024-04-09T22:44:49Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Neuroinflammation |
| spelling | doaj.art-644dd3a87c694826842c19ca5d8a5e5e2023-03-22T11:55:06ZengBMCJournal of Neuroinflammation1742-20942023-03-0120112110.1186/s12974-023-02734-9Cannabinoids in traumatic brain injury and related neuropathologies: preclinical and clinical research on endogenous, plant-derived, and synthetic compoundsBrittney R. Lins0Chidozie C. Anyaegbu1Sarah C. Hellewell2Melissa Papini3Terence McGonigle4Luca De Prato5Matthew Shales6Melinda Fitzgerald7Curtin Health Innovation Research Institute, Curtin UniversityCurtin Health Innovation Research Institute, Curtin UniversityCurtin Health Innovation Research Institute, Curtin UniversityCurtin Health Innovation Research Institute, Curtin UniversityCurtin Health Innovation Research Institute, Curtin UniversityMediCann Health Aust Pty LtdMediCann Health Aust Pty LtdCurtin Health Innovation Research Institute, Curtin UniversityAbstract Traumatic brain injury is common, and often results in debilitating consequences. Even mild traumatic brain injury leaves approximately 20% of patients with symptoms that persist for months. Despite great clinical need there are currently no approved pharmaceutical interventions that improve outcomes after traumatic brain injury. Increased understanding of the endocannabinoid system in health and disease has accompanied growing evidence for therapeutic benefits of Cannabis sativa. This has driven research of Cannabis’ active chemical constituents (phytocannabinoids), alongside endogenous and synthetic counterparts, collectively known as cannabinoids. Also of therapeutic interest are other Cannabis constituents, such as terpenes. Cannabinoids interact with neurons, microglia, and astrocytes, and exert anti-inflammatory and neuroprotective effects which are highly desirable for the management of traumatic brain injury. In this review, we comprehensively appraised the relevant scientific literature, where major and minor phytocannabinoids, terpenes, synthetic cannabinoids, and endogenous cannabinoids were assessed in TBI, or other neurological conditions with pathology and symptomology relevant to TBI, as well as recent studies in preclinical TBI models and clinical TBI populations.https://doi.org/10.1186/s12974-023-02734-9Traumatic brain injuryConcussionCNS injuryNeurotraumaEndocannabinoid systemTerpenes |
| spellingShingle | Brittney R. Lins Chidozie C. Anyaegbu Sarah C. Hellewell Melissa Papini Terence McGonigle Luca De Prato Matthew Shales Melinda Fitzgerald Cannabinoids in traumatic brain injury and related neuropathologies: preclinical and clinical research on endogenous, plant-derived, and synthetic compounds Journal of Neuroinflammation Traumatic brain injury Concussion CNS injury Neurotrauma Endocannabinoid system Terpenes |
| title | Cannabinoids in traumatic brain injury and related neuropathologies: preclinical and clinical research on endogenous, plant-derived, and synthetic compounds |
| title_full | Cannabinoids in traumatic brain injury and related neuropathologies: preclinical and clinical research on endogenous, plant-derived, and synthetic compounds |
| title_fullStr | Cannabinoids in traumatic brain injury and related neuropathologies: preclinical and clinical research on endogenous, plant-derived, and synthetic compounds |
| title_full_unstemmed | Cannabinoids in traumatic brain injury and related neuropathologies: preclinical and clinical research on endogenous, plant-derived, and synthetic compounds |
| title_short | Cannabinoids in traumatic brain injury and related neuropathologies: preclinical and clinical research on endogenous, plant-derived, and synthetic compounds |
| title_sort | cannabinoids in traumatic brain injury and related neuropathologies preclinical and clinical research on endogenous plant derived and synthetic compounds |
| topic | Traumatic brain injury Concussion CNS injury Neurotrauma Endocannabinoid system Terpenes |
| url | https://doi.org/10.1186/s12974-023-02734-9 |
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