Clinical Nocardia species: Identification, clinical characteristics, and antimicrobial susceptibility in Shandong, China
Nocardia is a pathogen responsible for a variety of clinical infections. Here, we aimed to investigate the species distribution, clinical manifestations, and antimicrobial susceptibility of Nocardia species over 3 years in two tertiary general hospitals in China. In this retrospective study, a tota...
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2020-11-01
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| Series: | Biomolecules & Biomedicine |
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| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/4764 |
| _version_ | 1797260940406685696 |
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| author | Shu-Hua Lu Zhen-Wen Qian Pei-Pei Mou Lian Xie |
| author_facet | Shu-Hua Lu Zhen-Wen Qian Pei-Pei Mou Lian Xie |
| author_sort | Shu-Hua Lu |
| collection | DOAJ |
| description |
Nocardia is a pathogen responsible for a variety of clinical infections. Here, we aimed to investigate the species distribution, clinical manifestations, and antimicrobial susceptibility of Nocardia species over 3 years in two tertiary general hospitals in China. In this retrospective study, a total of 27 Nocardia species were isolated from 27 individuals between January 2017 and December 2019. Nocardia isolates were identified to species level by mass spectrometry and 16S rRNA PCR sequencing. Clinical data were collected from medical records. Antimicrobial susceptibility was determined by the standard Broth microdilution method. The 27 patients with Nocardia infection included 12 males and 15 females with a mean age of 60.11 years. Among 27 Nocardia isolates, 7 species were identified, with the most common species being Nocardia otitidiscaviarum (40.7%). The antimicrobial susceptibility profiles varied between different Nocardia species. Notably, all Nocardia isolates were linezolid susceptible. The majority of Nocardia isolates were collected from a department of respiratory medicine (55.56%) and sputum specimen (44.44%). Pulmonary region was the most involved body site (70.37%) followed by skin (7.4%) and pleural cavity (7.4%). Most patients with Nocardia infection needed combination antibiotic therapy. Two deaths were reported during the treatment period and 24 patients achieved improvement after antibiotic therapy. The clinical manifestations of Nocardia infection and antimicrobial susceptibility profiles varied with diverse Nocardia species. Thus, the accurate identification of these species is crucial for the diagnosis and the selection of antibiotic treatment.
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| first_indexed | 2024-04-24T23:33:18Z |
| format | Article |
| id | doaj.art-644ec07be58d4306beff0bb97100fe2d |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:33:18Z |
| publishDate | 2020-11-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-644ec07be58d4306beff0bb97100fe2d2024-03-15T14:29:54ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2020-11-0120410.17305/bjbms.2020.4764Clinical Nocardia species: Identification, clinical characteristics, and antimicrobial susceptibility in Shandong, ChinaShu-Hua Lu0https://orcid.org/0000-0003-3099-2461Zhen-Wen Qian1Pei-Pei Mou2https://orcid.org/0000-0002-7234-3809Lian Xie3https://orcid.org/0000-0002-0195-8152Department of Clinical Laboratory, Affiliated Hospital of Jining Medical University, Jining, ChinaDepartment of Clinical Laboratory, Affiliated Hospital of Jining Medical University, Jining, ChinaDepartment of Clinical Laboratory, Shengli Oilfield Central Hospital, Dongying, ChinaDepartment of Clinical Laboratory, Shengli Oilfield Central Hospital, Dongying, China Nocardia is a pathogen responsible for a variety of clinical infections. Here, we aimed to investigate the species distribution, clinical manifestations, and antimicrobial susceptibility of Nocardia species over 3 years in two tertiary general hospitals in China. In this retrospective study, a total of 27 Nocardia species were isolated from 27 individuals between January 2017 and December 2019. Nocardia isolates were identified to species level by mass spectrometry and 16S rRNA PCR sequencing. Clinical data were collected from medical records. Antimicrobial susceptibility was determined by the standard Broth microdilution method. The 27 patients with Nocardia infection included 12 males and 15 females with a mean age of 60.11 years. Among 27 Nocardia isolates, 7 species were identified, with the most common species being Nocardia otitidiscaviarum (40.7%). The antimicrobial susceptibility profiles varied between different Nocardia species. Notably, all Nocardia isolates were linezolid susceptible. The majority of Nocardia isolates were collected from a department of respiratory medicine (55.56%) and sputum specimen (44.44%). Pulmonary region was the most involved body site (70.37%) followed by skin (7.4%) and pleural cavity (7.4%). Most patients with Nocardia infection needed combination antibiotic therapy. Two deaths were reported during the treatment period and 24 patients achieved improvement after antibiotic therapy. The clinical manifestations of Nocardia infection and antimicrobial susceptibility profiles varied with diverse Nocardia species. Thus, the accurate identification of these species is crucial for the diagnosis and the selection of antibiotic treatment. https://www.bjbms.org/ojs/index.php/bjbms/article/view/4764NocardiaNocardia infectionnocardiosisantimicrobial susceptibilitymass spectrometryidentification |
| spellingShingle | Shu-Hua Lu Zhen-Wen Qian Pei-Pei Mou Lian Xie Clinical Nocardia species: Identification, clinical characteristics, and antimicrobial susceptibility in Shandong, China Biomolecules & Biomedicine Nocardia Nocardia infection nocardiosis antimicrobial susceptibility mass spectrometry identification |
| title | Clinical Nocardia species: Identification, clinical characteristics, and antimicrobial susceptibility in Shandong, China |
| title_full | Clinical Nocardia species: Identification, clinical characteristics, and antimicrobial susceptibility in Shandong, China |
| title_fullStr | Clinical Nocardia species: Identification, clinical characteristics, and antimicrobial susceptibility in Shandong, China |
| title_full_unstemmed | Clinical Nocardia species: Identification, clinical characteristics, and antimicrobial susceptibility in Shandong, China |
| title_short | Clinical Nocardia species: Identification, clinical characteristics, and antimicrobial susceptibility in Shandong, China |
| title_sort | clinical nocardia species identification clinical characteristics and antimicrobial susceptibility in shandong china |
| topic | Nocardia Nocardia infection nocardiosis antimicrobial susceptibility mass spectrometry identification |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/4764 |
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