Decanal Protects against UVB-Induced Photoaging in Human Dermal Fibroblasts via the cAMP Pathway
Solar ultraviolet (UV) radiation is the primary factor of cutaneous aging, resulting in coarse wrinkles and dryness. In this study, we aimed to test whether decanal, an aromatic compound found mainly in citrus fruits, inhibits UVB-mediated photoaging in human dermal fibroblasts and to explore whethe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/5/1214 |
| _version_ | 1797569640220590080 |
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| author | Wesuk Kang Dabin Choi Taesun Park |
| author_facet | Wesuk Kang Dabin Choi Taesun Park |
| author_sort | Wesuk Kang |
| collection | DOAJ |
| description | Solar ultraviolet (UV) radiation is the primary factor of cutaneous aging, resulting in coarse wrinkles and dryness. In this study, we aimed to test whether decanal, an aromatic compound found mainly in citrus fruits, inhibits UVB-mediated photoaging in human dermal fibroblasts and to explore whether its anti-photoaging effect occurs via cyclic adenosine monophosphate (cAMP) signaling. We found that decanal promotes collagen production dose-dependently. Meanwhile, it also increased the intracellular cAMP levels and decreased the number of molecules involved in the mitogen-activated protein kinase (MAPK)/activator protein 1 (AP-1) pathway, downregulating the collagen genes and upregulating the matrix metalloproteinase (MMP) genes in UVB-exposed dermal fibroblasts. Furthermore, it enhanced hyaluronic acid levels and hyaluronic acid synthase mRNA expression. Notably, the beneficial effects of decanal were lost in the presence of a cAMP inhibitor. Our results revealed the potential of decanal for preventing photoaging and suggested that its effects are cAMP-mediated in human dermal fibroblasts. |
| first_indexed | 2024-03-10T20:13:40Z |
| format | Article |
| id | doaj.art-644efcbda5784b5680e413df9097bd24 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T20:13:40Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-644efcbda5784b5680e413df9097bd242023-11-19T22:43:08ZengMDPI AGNutrients2072-66432020-04-01125121410.3390/nu12051214Decanal Protects against UVB-Induced Photoaging in Human Dermal Fibroblasts via the cAMP PathwayWesuk Kang0Dabin Choi1Taesun Park2Department of Food and Nutrition, Brain Korea 21 PLUS Project, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, KoreaDepartment of Food and Nutrition, Brain Korea 21 PLUS Project, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, KoreaDepartment of Food and Nutrition, Brain Korea 21 PLUS Project, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, KoreaSolar ultraviolet (UV) radiation is the primary factor of cutaneous aging, resulting in coarse wrinkles and dryness. In this study, we aimed to test whether decanal, an aromatic compound found mainly in citrus fruits, inhibits UVB-mediated photoaging in human dermal fibroblasts and to explore whether its anti-photoaging effect occurs via cyclic adenosine monophosphate (cAMP) signaling. We found that decanal promotes collagen production dose-dependently. Meanwhile, it also increased the intracellular cAMP levels and decreased the number of molecules involved in the mitogen-activated protein kinase (MAPK)/activator protein 1 (AP-1) pathway, downregulating the collagen genes and upregulating the matrix metalloproteinase (MMP) genes in UVB-exposed dermal fibroblasts. Furthermore, it enhanced hyaluronic acid levels and hyaluronic acid synthase mRNA expression. Notably, the beneficial effects of decanal were lost in the presence of a cAMP inhibitor. Our results revealed the potential of decanal for preventing photoaging and suggested that its effects are cAMP-mediated in human dermal fibroblasts.https://www.mdpi.com/2072-6643/12/5/1214decanalUVBphotoagingcAMPhuman dermal fibroblast |
| spellingShingle | Wesuk Kang Dabin Choi Taesun Park Decanal Protects against UVB-Induced Photoaging in Human Dermal Fibroblasts via the cAMP Pathway Nutrients decanal UVB photoaging cAMP human dermal fibroblast |
| title | Decanal Protects against UVB-Induced Photoaging in Human Dermal Fibroblasts via the cAMP Pathway |
| title_full | Decanal Protects against UVB-Induced Photoaging in Human Dermal Fibroblasts via the cAMP Pathway |
| title_fullStr | Decanal Protects against UVB-Induced Photoaging in Human Dermal Fibroblasts via the cAMP Pathway |
| title_full_unstemmed | Decanal Protects against UVB-Induced Photoaging in Human Dermal Fibroblasts via the cAMP Pathway |
| title_short | Decanal Protects against UVB-Induced Photoaging in Human Dermal Fibroblasts via the cAMP Pathway |
| title_sort | decanal protects against uvb induced photoaging in human dermal fibroblasts via the camp pathway |
| topic | decanal UVB photoaging cAMP human dermal fibroblast |
| url | https://www.mdpi.com/2072-6643/12/5/1214 |
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