Teriflunomide Preserves Neuronal Activity and Protects Mitochondria in Brain Slices Exposed to Oxidative Stress

Teriflunomide Preserves Neuronal Activity and Protects Mitochondria in Brain Slices Exposed to Oxidative Stress

Teriflunomide (TFN) limits relapses in relapsing–remitting multiple sclerosis (RRMS) by reducing lymphocytic proliferation through the inhibition of the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) and the subsequent modulation of de novo pyrimidine synthesis. Alterations of mitochondri...

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Bibliographic Details
Main Authors: Bimala Malla, Agustin Liotta, Helena Bros, Rebecca Ulshöfer, Friedemann Paul, Anja E. Hauser, Raluca Niesner, Carmen Infante-Duarte
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
mitochondria
neurodegeneration
teriflunomide (TFN)
oxidative stress
dihydroorotate dehydrogenase (DHODH)
multiple sclerosis
Online Access:https://www.mdpi.com/1422-0067/23/3/1538

Internet

https://www.mdpi.com/1422-0067/23/3/1538

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