The anti-leukemia activity and mechanisms of shikonin: a mini review
Leukemia encompasses a group of highly heterogeneous diseases that pose a serious threat to human health. The long-term outcome of patients with leukemia still needs to be improved and new effective therapeutic strategies continue to be an unmet clinical need. Shikonin (SHK) is a naphthoquinone deri...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1271252/full |
| _version_ | 1827775379285213184 |
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| author | Han Dong Chun-Di Chang Fei Gao Na Zhang Xing-Jian Yan Xue Wu Yue-Hui Wang |
| author_facet | Han Dong Chun-Di Chang Fei Gao Na Zhang Xing-Jian Yan Xue Wu Yue-Hui Wang |
| author_sort | Han Dong |
| collection | DOAJ |
| description | Leukemia encompasses a group of highly heterogeneous diseases that pose a serious threat to human health. The long-term outcome of patients with leukemia still needs to be improved and new effective therapeutic strategies continue to be an unmet clinical need. Shikonin (SHK) is a naphthoquinone derivative that shows multiple biological function includes anti-tumor, anti-inflammatory, and anti-allergic effects. Numerous studies have reported the anti-leukemia activity of SHK during the last 3 decades and there are studies showing that SHK is particularly effective towards various leukemia cells compared to solid tumors. In this review, we will discuss the anti-leukemia effect of SHK and summarize the underlying mechanisms. Therefore, SHK may be a promising agent to be developed as an anti-leukemia drug. |
| first_indexed | 2024-03-11T13:49:09Z |
| format | Article |
| id | doaj.art-64523cd8e45949159432a678c7d7d3b7 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-11T13:49:09Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-64523cd8e45949159432a678c7d7d3b72023-11-02T09:26:53ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-11-011410.3389/fphar.2023.12712521271252The anti-leukemia activity and mechanisms of shikonin: a mini reviewHan Dong0Chun-Di Chang1Fei Gao2Na Zhang3Xing-Jian Yan4Xue Wu5Yue-Hui Wang6Department of Geriatrics, Jilin Geriatrics Clinical Research Center, The First Hospital of Jilin University, Changchun, ChinaDepartment of Neurology, Jilin Province People’s Hospital, Changchun, ChinaEndocrine Department, Qian Wei Hospital of Jilin Province, Changchun, ChinaElectrodiagnosis Department, Jilin Province FAW General Hospital, Changchun, ChinaDepartment of Urology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Geriatrics, Jilin Geriatrics Clinical Research Center, The First Hospital of Jilin University, Changchun, ChinaDepartment of Geriatrics, Jilin Geriatrics Clinical Research Center, The First Hospital of Jilin University, Changchun, ChinaLeukemia encompasses a group of highly heterogeneous diseases that pose a serious threat to human health. The long-term outcome of patients with leukemia still needs to be improved and new effective therapeutic strategies continue to be an unmet clinical need. Shikonin (SHK) is a naphthoquinone derivative that shows multiple biological function includes anti-tumor, anti-inflammatory, and anti-allergic effects. Numerous studies have reported the anti-leukemia activity of SHK during the last 3 decades and there are studies showing that SHK is particularly effective towards various leukemia cells compared to solid tumors. In this review, we will discuss the anti-leukemia effect of SHK and summarize the underlying mechanisms. Therefore, SHK may be a promising agent to be developed as an anti-leukemia drug.https://www.frontiersin.org/articles/10.3389/fphar.2023.1271252/fullleukemiashikoninanti-leukemia activitymechanismsmultiple targets |
| spellingShingle | Han Dong Chun-Di Chang Fei Gao Na Zhang Xing-Jian Yan Xue Wu Yue-Hui Wang The anti-leukemia activity and mechanisms of shikonin: a mini review Frontiers in Pharmacology leukemia shikonin anti-leukemia activity mechanisms multiple targets |
| title | The anti-leukemia activity and mechanisms of shikonin: a mini review |
| title_full | The anti-leukemia activity and mechanisms of shikonin: a mini review |
| title_fullStr | The anti-leukemia activity and mechanisms of shikonin: a mini review |
| title_full_unstemmed | The anti-leukemia activity and mechanisms of shikonin: a mini review |
| title_short | The anti-leukemia activity and mechanisms of shikonin: a mini review |
| title_sort | anti leukemia activity and mechanisms of shikonin a mini review |
| topic | leukemia shikonin anti-leukemia activity mechanisms multiple targets |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1271252/full |
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