Development and characterization of solid lipid nanoparticles for enhancement of oral bioavailability of Raloxifene

Development and characterization of solid lipid nanoparticles for enhancement of oral bioavailability of Raloxifene

The objective of this study was to increase the oral bioavailability of Raloxifene having an absolute bioavailability only 2% due to extensive first pass hepatic metabolism by incorporating it in Solid Lipid Nanoparticles (SLNs). The optimized RSLNs prepared by Ultrasonic Emulsification and Low Temp...

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Bibliographic Details
Main Authors: B Divyakant Patel, R Valay Modi, N Alok Thakkar, A Arpita Patel, P Hetal Thakkar
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2012-01-01
Series:Journal of Pharmacy and Bioallied Sciences
Subjects:
Drug entrapment
estrogen
solvent emulsification
zeta potential
Online Access:http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2012;volume=4;issue=5;spage=14;epage=16;aulast=Patel

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