Evaluation of the Anti-<i>Leishmania mexicana</i> and -<i>Trypanosoma brucei</i> Activity and Mode of Action of 4,4′-(Arylmethylene)bis(3-methyl-1-phenyl-1<i>H</i>-pyrazol-5-ol)

Evaluation of the Anti-<i>Leishmania mexicana</i> and -<i>Trypanosoma brucei</i> Activity and Mode of Action of 4,4′-(Arylmethylene)bis(3-methyl-1-phenyl-1<i>H</i>-pyrazol-5-ol)

Trypanosomiasis and leishmaniasis are neglected infections caused by trypanosomatid parasites. The first-line treatments have many adverse effects, high costs, and are prone to resistance development, hence the necessity for new chemotherapeutic options. In line with this, twenty five 4,4′-(arylmeth...

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Bibliographic Details
Main Authors: Olalla Barreiro-Costa, Cristina Quiroga Lozano, Erika Muñoz, Patricio Rojas-Silva, Andrea Medeiros, Marcelo A. Comini, Jorge Heredia-Moya
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biomedicines
Subjects:
4,4′-(arylmethylene)bis(1<i>H</i>-pyrazol-5-ols)
<i>Trypanosoma</i>
<i>Leishmania</i>
drug-like
ADME
redox biosensor
Online Access:https://www.mdpi.com/2227-9059/10/8/1913

Internet

https://www.mdpi.com/2227-9059/10/8/1913

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