Janus kinase 2 V617F mutation in an unrelated peripheral blood stem cell donor
Polycythemia vera (PV) is relatively uncommon in early adulthood, and evidence about the prevalence of the Janus kinase 2 (JAK2) V617F mutation in the general population is limited. Here, we report a previously healthy volunteer peripheral blood stem cell (PBSC) donor who developed symptomatic PV wi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Tzu-Chi Medical Journal |
| Subjects: | |
| Online Access: | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2019;volume=31;issue=1;spage=60;epage=62;aulast=Yang |
| _version_ | 1811310112052084736 |
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| author | Shang-Hsien Yang Hsiang-Lin Wan Ming-Hui Gu Tso-Fu Wang |
| author_facet | Shang-Hsien Yang Hsiang-Lin Wan Ming-Hui Gu Tso-Fu Wang |
| author_sort | Shang-Hsien Yang |
| collection | DOAJ |
| description | Polycythemia vera (PV) is relatively uncommon in early adulthood, and evidence about the prevalence of the Janus kinase 2 (JAK2) V617F mutation in the general population is limited. Here, we report a previously healthy volunteer peripheral blood stem cell (PBSC) donor who developed symptomatic PV with the JAK2 V617F mutation 2 years after PBSC mobilization and harvest. The characteristic mutation was identified retrospectively in the blood sample of the donor at the confirmation typing stage, which was before granulocyte colony-stimulating factor injection. This report presents a safety issue for both donor and recipient of hematopoietic stem cell transplantation. Clinicians should be aware of this during health workup and postdonation follow-up of unrelated PBSC donors. Any abnormal and/or equivocal laboratory data, especially during the donor workup stage, should not be overlooked. |
| first_indexed | 2024-04-13T09:53:48Z |
| format | Article |
| id | doaj.art-64593fc44dd44b52a27ec96525909d70 |
| institution | Directory Open Access Journal |
| issn | 1016-3190 2223-8956 |
| language | English |
| last_indexed | 2024-04-13T09:53:48Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tzu-Chi Medical Journal |
| spelling | doaj.art-64593fc44dd44b52a27ec96525909d702022-12-22T02:51:31ZengWolters Kluwer Medknow PublicationsTzu-Chi Medical Journal1016-31902223-89562019-01-01311606210.4103/tcmj.tcmj_189_17Janus kinase 2 V617F mutation in an unrelated peripheral blood stem cell donorShang-Hsien YangHsiang-Lin WanMing-Hui GuTso-Fu WangPolycythemia vera (PV) is relatively uncommon in early adulthood, and evidence about the prevalence of the Janus kinase 2 (JAK2) V617F mutation in the general population is limited. Here, we report a previously healthy volunteer peripheral blood stem cell (PBSC) donor who developed symptomatic PV with the JAK2 V617F mutation 2 years after PBSC mobilization and harvest. The characteristic mutation was identified retrospectively in the blood sample of the donor at the confirmation typing stage, which was before granulocyte colony-stimulating factor injection. This report presents a safety issue for both donor and recipient of hematopoietic stem cell transplantation. Clinicians should be aware of this during health workup and postdonation follow-up of unrelated PBSC donors. Any abnormal and/or equivocal laboratory data, especially during the donor workup stage, should not be overlooked.http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2019;volume=31;issue=1;spage=60;epage=62;aulast=YangGranulocyte colony-stimulating factorJanus kinase 2 V617F mutationPeripheral blood stem cell harvestPolycythemia veraUnrelated donor |
| spellingShingle | Shang-Hsien Yang Hsiang-Lin Wan Ming-Hui Gu Tso-Fu Wang Janus kinase 2 V617F mutation in an unrelated peripheral blood stem cell donor Tzu-Chi Medical Journal Granulocyte colony-stimulating factor Janus kinase 2 V617F mutation Peripheral blood stem cell harvest Polycythemia vera Unrelated donor |
| title | Janus kinase 2 V617F mutation in an unrelated peripheral blood stem cell donor |
| title_full | Janus kinase 2 V617F mutation in an unrelated peripheral blood stem cell donor |
| title_fullStr | Janus kinase 2 V617F mutation in an unrelated peripheral blood stem cell donor |
| title_full_unstemmed | Janus kinase 2 V617F mutation in an unrelated peripheral blood stem cell donor |
| title_short | Janus kinase 2 V617F mutation in an unrelated peripheral blood stem cell donor |
| title_sort | janus kinase 2 v617f mutation in an unrelated peripheral blood stem cell donor |
| topic | Granulocyte colony-stimulating factor Janus kinase 2 V617F mutation Peripheral blood stem cell harvest Polycythemia vera Unrelated donor |
| url | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2019;volume=31;issue=1;spage=60;epage=62;aulast=Yang |
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