Antagonizing Activin A/p15<sup>INK4b</sup> Signaling as Therapeutic Strategy for Liver Disease

Antagonizing Activin A/p15<sup>INK4b</sup> Signaling as Therapeutic Strategy for Liver Disease

Background/Aim: Activin A is involved in the pathogenesis of human liver diseases, but its therapeutic targeting is not fully explored. Here, we tested the effect of novel, highly specific small-molecule-based activin A antagonists (NUCC-474/555) in improving liver regeneration following partial hep...

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Bibliographic Details
Main Authors: Sowmya Mekala, Ravi Rai, Samantha Loretta Reed, Bill Bowen, George K. Michalopoulos, Joseph Locker, Reben Raeman, Michael Oertel
Format: Article
Language:English
Published: MDPI AG 2024-04-01
Series:Cells
Subjects:
liver regeneration
cell cycle arrest
senescence
activin antagonist
liver fibrosis
Online Access:https://www.mdpi.com/2073-4409/13/7/649

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