Epidemiologic, Clinical, and Genetic Characteristics of Human Infections with Influenza A(H5N6) Viruses, China
The recent rise in the frequency of influenza A(H5N6) infections in China has raised serious concerns about whether the risk for human infection has increased. We surveyed epidemiologic, clinical, and genetic data of human infections with A(H5N6) viruses. Severe disease occurred in 93.8% of cases,...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2022-07-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/28/7/21-2482_article |
| _version_ | 1818548301784416256 |
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| author | Wenfei Zhu Xiyan Li Jie Dong Hong Bo Jia Liu Jiaying Yang Ye Zhang Hejiang Wei Weijuan Huang Xiang Zhao Tao Chen Jing Yang Zi Li Xiaoxu Zeng Chao Li Jing Tang Li Xin Rongbao Gao Liqi Liu Min Tan Yuelong Shu Lei Yang Dayan Wang |
| author_facet | Wenfei Zhu Xiyan Li Jie Dong Hong Bo Jia Liu Jiaying Yang Ye Zhang Hejiang Wei Weijuan Huang Xiang Zhao Tao Chen Jing Yang Zi Li Xiaoxu Zeng Chao Li Jing Tang Li Xin Rongbao Gao Liqi Liu Min Tan Yuelong Shu Lei Yang Dayan Wang |
| author_sort | Wenfei Zhu |
| collection | DOAJ |
| description |
The recent rise in the frequency of influenza A(H5N6) infections in China has raised serious concerns about whether the risk for human infection has increased. We surveyed epidemiologic, clinical, and genetic data of human infections with A(H5N6) viruses. Severe disease occurred in 93.8% of cases, and the fatality rate was 55.4%. Median patient age was 51 years. Most H5N6 hemagglutinin (HA) genes in human isolates in 2021 originated from subclade 2.3.4.4b; we estimated the time to most recent common ancestor as June 16, 2020. A total of 13 genotypes with HA genes from multiple subclades in clade 2.3.4.4 were identified in human isolates. Of note, 4 new genotypes detected in 2021 were the major causes of increased H5N6 virus infections. Mammalian-adapted mutations were found in HA and internal genes. Although we found no evidence of human-to-human transmission, continuous evolution of H5N6 viruses may increase the risk for human infections.
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| first_indexed | 2024-12-12T08:18:08Z |
| format | Article |
| id | doaj.art-645d33e190064ea9bf80c3a2d8a8467f |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-12T08:18:08Z |
| publishDate | 2022-07-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-645d33e190064ea9bf80c3a2d8a8467f2022-12-22T00:31:29ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592022-07-012871332134410.3201/eid2807.212482Epidemiologic, Clinical, and Genetic Characteristics of Human Infections with Influenza A(H5N6) Viruses, ChinaWenfei ZhuXiyan LiJie DongHong BoJia LiuJiaying YangYe ZhangHejiang WeiWeijuan HuangXiang ZhaoTao ChenJing YangZi LiXiaoxu ZengChao LiJing TangLi XinRongbao GaoLiqi LiuMin TanYuelong ShuLei YangDayan Wang The recent rise in the frequency of influenza A(H5N6) infections in China has raised serious concerns about whether the risk for human infection has increased. We surveyed epidemiologic, clinical, and genetic data of human infections with A(H5N6) viruses. Severe disease occurred in 93.8% of cases, and the fatality rate was 55.4%. Median patient age was 51 years. Most H5N6 hemagglutinin (HA) genes in human isolates in 2021 originated from subclade 2.3.4.4b; we estimated the time to most recent common ancestor as June 16, 2020. A total of 13 genotypes with HA genes from multiple subclades in clade 2.3.4.4 were identified in human isolates. Of note, 4 new genotypes detected in 2021 were the major causes of increased H5N6 virus infections. Mammalian-adapted mutations were found in HA and internal genes. Although we found no evidence of human-to-human transmission, continuous evolution of H5N6 viruses may increase the risk for human infections. https://wwwnc.cdc.gov/eid/article/28/7/21-2482_articleinfluenzainfluenza A(H5N6) viruseshuman infectionepidemiologygenetic characteristicszoonoses |
| spellingShingle | Wenfei Zhu Xiyan Li Jie Dong Hong Bo Jia Liu Jiaying Yang Ye Zhang Hejiang Wei Weijuan Huang Xiang Zhao Tao Chen Jing Yang Zi Li Xiaoxu Zeng Chao Li Jing Tang Li Xin Rongbao Gao Liqi Liu Min Tan Yuelong Shu Lei Yang Dayan Wang Epidemiologic, Clinical, and Genetic Characteristics of Human Infections with Influenza A(H5N6) Viruses, China Emerging Infectious Diseases influenza influenza A(H5N6) viruses human infection epidemiology genetic characteristics zoonoses |
| title | Epidemiologic, Clinical, and Genetic Characteristics of Human Infections with Influenza A(H5N6) Viruses, China |
| title_full | Epidemiologic, Clinical, and Genetic Characteristics of Human Infections with Influenza A(H5N6) Viruses, China |
| title_fullStr | Epidemiologic, Clinical, and Genetic Characteristics of Human Infections with Influenza A(H5N6) Viruses, China |
| title_full_unstemmed | Epidemiologic, Clinical, and Genetic Characteristics of Human Infections with Influenza A(H5N6) Viruses, China |
| title_short | Epidemiologic, Clinical, and Genetic Characteristics of Human Infections with Influenza A(H5N6) Viruses, China |
| title_sort | epidemiologic clinical and genetic characteristics of human infections with influenza a h5n6 viruses china |
| topic | influenza influenza A(H5N6) viruses human infection epidemiology genetic characteristics zoonoses |
| url | https://wwwnc.cdc.gov/eid/article/28/7/21-2482_article |
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