EHMT1/GLP; Biochemical Function and Association with Brain Disorders
The gene EHMT1 that encodes the Euchromatic Histone Methyltransferase-1, also known as GLP (G9a-like protein), has been associated with a number of neurodevelopmental and neurodegenerative disorders. GLP is a member of the euchromatic lysine histone methyltransferase family, along with EHMT2 or G9A....
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-10-01
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| Series: | Epigenomes |
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| Online Access: | https://www.mdpi.com/2075-4655/1/3/15 |
| _version_ | 1797757827551330304 |
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| author | Manal A. Adam Anthony R. Isles |
| author_facet | Manal A. Adam Anthony R. Isles |
| author_sort | Manal A. Adam |
| collection | DOAJ |
| description | The gene EHMT1 that encodes the Euchromatic Histone Methyltransferase-1, also known as GLP (G9a-like protein), has been associated with a number of neurodevelopmental and neurodegenerative disorders. GLP is a member of the euchromatic lysine histone methyltransferase family, along with EHMT2 or G9A. As its name implies, Ehmt1/GLP is involved in the addition of methyl groups to histone H3 lysine 9, a generally repressive mark linked to classical epigenetic process such as genomic imprinting, X-inactivation, and heterochromatin formation. However, GLP also plays both a direct and indirect role in regulating DNA-methylation. Here, we discuss what is currently known about the biochemical function of Ehmt1/GLP and its association, via various genetic studies, with brain disorders. |
| first_indexed | 2024-03-12T18:21:09Z |
| format | Article |
| id | doaj.art-645e4d4713c34d05b83148a0a3eb79c4 |
| institution | Directory Open Access Journal |
| issn | 2075-4655 |
| language | English |
| last_indexed | 2024-03-12T18:21:09Z |
| publishDate | 2017-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Epigenomes |
| spelling | doaj.art-645e4d4713c34d05b83148a0a3eb79c42023-08-02T08:55:25ZengMDPI AGEpigenomes2075-46552017-10-01131510.3390/epigenomes1030015epigenomes1030015EHMT1/GLP; Biochemical Function and Association with Brain DisordersManal A. Adam0Anthony R. Isles1MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, CF24 4HQ, UKMRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, CF24 4HQ, UKThe gene EHMT1 that encodes the Euchromatic Histone Methyltransferase-1, also known as GLP (G9a-like protein), has been associated with a number of neurodevelopmental and neurodegenerative disorders. GLP is a member of the euchromatic lysine histone methyltransferase family, along with EHMT2 or G9A. As its name implies, Ehmt1/GLP is involved in the addition of methyl groups to histone H3 lysine 9, a generally repressive mark linked to classical epigenetic process such as genomic imprinting, X-inactivation, and heterochromatin formation. However, GLP also plays both a direct and indirect role in regulating DNA-methylation. Here, we discuss what is currently known about the biochemical function of Ehmt1/GLP and its association, via various genetic studies, with brain disorders.https://www.mdpi.com/2075-4655/1/3/15Ehmt1/GLPG9ahistone methyltransferaseDNA methylationneurodevelopmentneurodegeneration |
| spellingShingle | Manal A. Adam Anthony R. Isles EHMT1/GLP; Biochemical Function and Association with Brain Disorders Epigenomes Ehmt1/GLP G9a histone methyltransferase DNA methylation neurodevelopment neurodegeneration |
| title | EHMT1/GLP; Biochemical Function and Association with Brain Disorders |
| title_full | EHMT1/GLP; Biochemical Function and Association with Brain Disorders |
| title_fullStr | EHMT1/GLP; Biochemical Function and Association with Brain Disorders |
| title_full_unstemmed | EHMT1/GLP; Biochemical Function and Association with Brain Disorders |
| title_short | EHMT1/GLP; Biochemical Function and Association with Brain Disorders |
| title_sort | ehmt1 glp biochemical function and association with brain disorders |
| topic | Ehmt1/GLP G9a histone methyltransferase DNA methylation neurodevelopment neurodegeneration |
| url | https://www.mdpi.com/2075-4655/1/3/15 |
| work_keys_str_mv | AT manalaadam ehmt1glpbiochemicalfunctionandassociationwithbraindisorders AT anthonyrisles ehmt1glpbiochemicalfunctionandassociationwithbraindisorders |