The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics
Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the necrosis of tumors, but it has been recently identified to have additional important functions as a pathological component of autoimmune diseases. TNF-α binds to two different receptors, which initiate signal tr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/5/2719 |
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| author | Dan-in Jang A-Hyeon Lee Hye-Yoon Shin Hyo-Ryeong Song Jong-Hwi Park Tae-Bong Kang Sang-Ryong Lee Seung-Hoon Yang |
| author_facet | Dan-in Jang A-Hyeon Lee Hye-Yoon Shin Hyo-Ryeong Song Jong-Hwi Park Tae-Bong Kang Sang-Ryong Lee Seung-Hoon Yang |
| author_sort | Dan-in Jang |
| collection | DOAJ |
| description | Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the necrosis of tumors, but it has been recently identified to have additional important functions as a pathological component of autoimmune diseases. TNF-α binds to two different receptors, which initiate signal transduction pathways. These pathways lead to various cellular responses, including cell survival, differentiation, and proliferation. However, the inappropriate or excessive activation of TNF-α signaling is associated with chronic inflammation and can eventually lead to the development of pathological complications such as autoimmune diseases. Understanding of the TNF-α signaling mechanism has been expanded and applied for the treatment of immune diseases, which has resulted in the development of effective therapeutic tools, including TNF-α inhibitors. Currently, clinically approved TNF-α inhibitors have shown noticeable potency in a variety of autoimmune diseases, and novel TNF-α signaling inhibitors are being clinically evaluated. In this review, we briefly introduce the impact of TNF-α signaling on autoimmune diseases and its inhibitors, which are used as therapeutic agents against autoimmune diseases. |
| first_indexed | 2024-03-09T05:01:05Z |
| format | Article |
| id | doaj.art-6460cd9e0e044f34bf6e7bf345ed04e3 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T05:01:05Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6460cd9e0e044f34bf6e7bf345ed04e32023-12-03T13:00:11ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-03-01225271910.3390/ijms22052719The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in TherapeuticsDan-in Jang0A-Hyeon Lee1Hye-Yoon Shin2Hyo-Ryeong Song3Jong-Hwi Park4Tae-Bong Kang5Sang-Ryong Lee6Seung-Hoon Yang7Department of Medical Biotechnology, Collage of Life Science and Biotechnology, Dongguk University, Seoul 04620, KoreaDepartment of Medical Biotechnology, Collage of Life Science and Biotechnology, Dongguk University, Seoul 04620, KoreaSchool of Life Science, Handong Global University, Pohang, Gyeongbuk 37554, KoreaDepartment of Medical Biotechnology, Collage of Life Science and Biotechnology, Dongguk University, Seoul 04620, KoreaDepartment of Medical Biotechnology, Collage of Life Science and Biotechnology, Dongguk University, Seoul 04620, KoreaDepartment of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju 27478, KoreaDepartment of Biological Environmental Science, Collage of Life Science and Biotechnology, Dongguk University, Seoul 04620, KoreaDepartment of Medical Biotechnology, Collage of Life Science and Biotechnology, Dongguk University, Seoul 04620, KoreaTumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the necrosis of tumors, but it has been recently identified to have additional important functions as a pathological component of autoimmune diseases. TNF-α binds to two different receptors, which initiate signal transduction pathways. These pathways lead to various cellular responses, including cell survival, differentiation, and proliferation. However, the inappropriate or excessive activation of TNF-α signaling is associated with chronic inflammation and can eventually lead to the development of pathological complications such as autoimmune diseases. Understanding of the TNF-α signaling mechanism has been expanded and applied for the treatment of immune diseases, which has resulted in the development of effective therapeutic tools, including TNF-α inhibitors. Currently, clinically approved TNF-α inhibitors have shown noticeable potency in a variety of autoimmune diseases, and novel TNF-α signaling inhibitors are being clinically evaluated. In this review, we briefly introduce the impact of TNF-α signaling on autoimmune diseases and its inhibitors, which are used as therapeutic agents against autoimmune diseases.https://www.mdpi.com/1422-0067/22/5/2719TNF-αautoimmune diseasesrheumatoid arthritisinflammatory bowel diseasepsoriatic arthritisTNF-α inhibitors |
| spellingShingle | Dan-in Jang A-Hyeon Lee Hye-Yoon Shin Hyo-Ryeong Song Jong-Hwi Park Tae-Bong Kang Sang-Ryong Lee Seung-Hoon Yang The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics International Journal of Molecular Sciences TNF-α autoimmune diseases rheumatoid arthritis inflammatory bowel disease psoriatic arthritis TNF-α inhibitors |
| title | The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics |
| title_full | The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics |
| title_fullStr | The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics |
| title_full_unstemmed | The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics |
| title_short | The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics |
| title_sort | role of tumor necrosis factor alpha tnf α in autoimmune disease and current tnf α inhibitors in therapeutics |
| topic | TNF-α autoimmune diseases rheumatoid arthritis inflammatory bowel disease psoriatic arthritis TNF-α inhibitors |
| url | https://www.mdpi.com/1422-0067/22/5/2719 |
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