Spray-dried porcine plasma enhances feed efficiency, intestinal integrity, and immune response of broilers challenged with necrotic enteritis
ABSTRACT: Re-emergence of enteric diseases in the postantibiotic era has imposed severe loss to the poultry industry leading to the urgent need for appropriate additives to maintain gut health. Recently, more attention has been paid to animal plasma due to its high concentrations of active component...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-03-01
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| Series: | Poultry Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0032579122007258 |
| _version_ | 1811162733838598144 |
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| author | A. Daneshmand N.K. Sharma T.H. Dao R. Barekatain R.A. Swick S.-B. Wu |
| author_facet | A. Daneshmand N.K. Sharma T.H. Dao R. Barekatain R.A. Swick S.-B. Wu |
| author_sort | A. Daneshmand |
| collection | DOAJ |
| description | ABSTRACT: Re-emergence of enteric diseases in the postantibiotic era has imposed severe loss to the poultry industry leading to the urgent need for appropriate additives to maintain gut health. Recently, more attention has been paid to animal plasma due to its high concentrations of active components such as albumins and globulins. The objective of this study was to evaluate the effects of spray-dried porcine plasma (SDP) supplementation during the starter phase (d 0–10) on growth performance, intestine health, and immune response of broilers under necrotic enteritis (NE) challenge. A total of 720 day-old male broiler parental line chicks (Ross 308) were randomly assigned to a 2 (NE challenge: no, yes) × 2 (SDP: 0, 2%) factorial arrangement with 12 replications of 15 chicks each. To induce NE, birds were inoculated with live Eimeria vaccine on d 9 and Clostridium perfringens on d 14. The body weight of birds and feed consumption were measured per pen on d 8, 10, 24, and 29 to calculate performance parameters. On d 16, three birds per pen were sampled to analyse the intestinal lesion score, gut permeability, villi morphology, relative weight of organs, and immune response. Results showed that SDP improved (P < 0.001) FCR in the pre-challenge phase (d 0–8). The results indicated that supplementing SDP lowered (P < 0.01) FCR at the end of the experiment (d 29). Dietary SDP decreased (P < 0.05) the concentration of FITC-d in serum samples of challenged broilers, although it did not affect the intestinal morphology and lesion score. Birds fed with SDP had a higher (P < 0.05) relative weight of bursa (g/kg live body weight) compared to non-supplemented birds. Supplementing SDP reduced the concentration of interleukin-6 (P < 0.05) and α-1 acid glycoprotein (P = 0.051) in serum samples of broilers. In conclusion, supplementation of SDP in the starter phase enhanced feed efficiency and gut integrity in NE challenged broilers, possibly through manipulating the immune response, while further studies targeting intestinal microflora and key genes are required to explore the mode of action. |
| first_indexed | 2024-04-10T06:35:06Z |
| format | Article |
| id | doaj.art-6461454c4f134ad3b625c1d82f01c4bd |
| institution | Directory Open Access Journal |
| issn | 0032-5791 |
| language | English |
| last_indexed | 2024-04-10T06:35:06Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Poultry Science |
| spelling | doaj.art-6461454c4f134ad3b625c1d82f01c4bd2023-03-01T04:30:19ZengElsevierPoultry Science0032-57912023-03-011023102431Spray-dried porcine plasma enhances feed efficiency, intestinal integrity, and immune response of broilers challenged with necrotic enteritisA. Daneshmand0N.K. Sharma1T.H. Dao2R. Barekatain3R.A. Swick4S.-B. Wu5School of Environmental and Rural Science, University of New England, Armidale, 2351 NSW, AustraliaSchool of Environmental and Rural Science, University of New England, Armidale, 2351 NSW, AustraliaSchool of Environmental and Rural Science, University of New England, Armidale, 2351 NSW, AustraliaSouth Australian Research and Development Institute, Roseworthy Campus, University of Adelaide, Roseworthy, 5371 SA, AustraliaSchool of Environmental and Rural Science, University of New England, Armidale, 2351 NSW, AustraliaSchool of Environmental and Rural Science, University of New England, Armidale, 2351 NSW, Australia; Corresponding author:ABSTRACT: Re-emergence of enteric diseases in the postantibiotic era has imposed severe loss to the poultry industry leading to the urgent need for appropriate additives to maintain gut health. Recently, more attention has been paid to animal plasma due to its high concentrations of active components such as albumins and globulins. The objective of this study was to evaluate the effects of spray-dried porcine plasma (SDP) supplementation during the starter phase (d 0–10) on growth performance, intestine health, and immune response of broilers under necrotic enteritis (NE) challenge. A total of 720 day-old male broiler parental line chicks (Ross 308) were randomly assigned to a 2 (NE challenge: no, yes) × 2 (SDP: 0, 2%) factorial arrangement with 12 replications of 15 chicks each. To induce NE, birds were inoculated with live Eimeria vaccine on d 9 and Clostridium perfringens on d 14. The body weight of birds and feed consumption were measured per pen on d 8, 10, 24, and 29 to calculate performance parameters. On d 16, three birds per pen were sampled to analyse the intestinal lesion score, gut permeability, villi morphology, relative weight of organs, and immune response. Results showed that SDP improved (P < 0.001) FCR in the pre-challenge phase (d 0–8). The results indicated that supplementing SDP lowered (P < 0.01) FCR at the end of the experiment (d 29). Dietary SDP decreased (P < 0.05) the concentration of FITC-d in serum samples of challenged broilers, although it did not affect the intestinal morphology and lesion score. Birds fed with SDP had a higher (P < 0.05) relative weight of bursa (g/kg live body weight) compared to non-supplemented birds. Supplementing SDP reduced the concentration of interleukin-6 (P < 0.05) and α-1 acid glycoprotein (P = 0.051) in serum samples of broilers. In conclusion, supplementation of SDP in the starter phase enhanced feed efficiency and gut integrity in NE challenged broilers, possibly through manipulating the immune response, while further studies targeting intestinal microflora and key genes are required to explore the mode of action.http://www.sciencedirect.com/science/article/pii/S0032579122007258spray-dried porcine plasma (SDP)intestinal morphologyα-1 acid glycoproteinimmunoglobulinbroiler chicken |
| spellingShingle | A. Daneshmand N.K. Sharma T.H. Dao R. Barekatain R.A. Swick S.-B. Wu Spray-dried porcine plasma enhances feed efficiency, intestinal integrity, and immune response of broilers challenged with necrotic enteritis Poultry Science spray-dried porcine plasma (SDP) intestinal morphology α-1 acid glycoprotein immunoglobulin broiler chicken |
| title | Spray-dried porcine plasma enhances feed efficiency, intestinal integrity, and immune response of broilers challenged with necrotic enteritis |
| title_full | Spray-dried porcine plasma enhances feed efficiency, intestinal integrity, and immune response of broilers challenged with necrotic enteritis |
| title_fullStr | Spray-dried porcine plasma enhances feed efficiency, intestinal integrity, and immune response of broilers challenged with necrotic enteritis |
| title_full_unstemmed | Spray-dried porcine plasma enhances feed efficiency, intestinal integrity, and immune response of broilers challenged with necrotic enteritis |
| title_short | Spray-dried porcine plasma enhances feed efficiency, intestinal integrity, and immune response of broilers challenged with necrotic enteritis |
| title_sort | spray dried porcine plasma enhances feed efficiency intestinal integrity and immune response of broilers challenged with necrotic enteritis |
| topic | spray-dried porcine plasma (SDP) intestinal morphology α-1 acid glycoprotein immunoglobulin broiler chicken |
| url | http://www.sciencedirect.com/science/article/pii/S0032579122007258 |
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