Population pharmacokinetic and pharmacodynamic modeling of evobrutinib in healthy adult participants

Population pharmacokinetic and pharmacodynamic modeling of evobrutinib in healthy adult participants

Abstract Evobrutinib, a Bruton's tyrosine kinase (BTK) inhibitor, has shown therapeutic potential in relapsing multiple sclerosis. This analysis aimed to develop pharmacokinetic (PK) and pharmacodynamic (PD; BTK occupancy [BTKO]) models of evobrutinib and simulate PK and BTKO profiles under alt...

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Bibliographic Details
Main Authors: Orestis Papasouliotis, David Mitchell, Pascal Girard, Martin Dyroff
Format: Article
Language:English
Published: Wiley 2022-12-01
Series:Clinical and Translational Science
Online Access:https://doi.org/10.1111/cts.13417

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