Residual Activatability of Circulating Tfh17 Predicts Humoral Response to Thymodependent Antigens in Patients on Therapeutic Immunosuppression

Residual Activatability of Circulating Tfh17 Predicts Humoral Response to Thymodependent Antigens in Patients on Therapeutic Immunosuppression

The generation of antibodies against protein antigens (such as donor-specific HLA molecules) requires that T follicular helper cells (Tfh) provide help to B cells. Immunosuppressive (IS) armamentarium prevents T cell activation, yet a significant proportion of renal transplant patients develop donor...

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Bibliographic Details
Main Authors: Suzan Dahdal, Carole Saison, Martine Valette, Emmanuel Bachy, Nicolas Pallet, Bruno Lina, Alice Koenig, Guillaume Monneret, Thierry Defrance, Emmanuel Morelon, Olivier Thaunat
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
transplantation
donor-specific antibodies
biomarkers
Tfh
immunosuppression
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03178/full

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