A randomized, feasibility trial of an exercise and nutrition‐based rehabilitation programme (ENeRgy) in people with cancer
Abstract Background Despite rehabilitation being increasingly advocated for people living with incurable cancer, there is limited evidence supporting efficacy or component parts. The progressive decline in function and nutritional in this population would support an approach that targets these facto...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-12-01
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| Series: | Journal of Cachexia, Sarcopenia and Muscle |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jcsm.12806 |
| _version_ | 1798032620528861184 |
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| author | Charlie C. Hall Richard J.E. Skipworth Honor Blackwood Duncan Brown Jane Cook Katharina Diernberger Elizabeth Dixon Valerie Gibson Catriona Graham Peter Hall Erna Haraldsdottir Jane Hopkinson Anna Lloyd Matthew Maddocks Lucy Norris Sharon Tuck Marie T. Fallon Barry J.A. Laird |
| author_facet | Charlie C. Hall Richard J.E. Skipworth Honor Blackwood Duncan Brown Jane Cook Katharina Diernberger Elizabeth Dixon Valerie Gibson Catriona Graham Peter Hall Erna Haraldsdottir Jane Hopkinson Anna Lloyd Matthew Maddocks Lucy Norris Sharon Tuck Marie T. Fallon Barry J.A. Laird |
| author_sort | Charlie C. Hall |
| collection | DOAJ |
| description | Abstract Background Despite rehabilitation being increasingly advocated for people living with incurable cancer, there is limited evidence supporting efficacy or component parts. The progressive decline in function and nutritional in this population would support an approach that targets these factors. This trial aimed to assess the feasibility of an exercise and nutrition based rehabilitation programme in people with incurable cancer. Methods We randomized community dwelling adults with incurable cancer to either a personalized exercise and nutrition based programme (experimental arm) or standard care (control arm) for 8 weeks. Endpoints included feasibility, quality of life, physical activity (step count), and body weight. Qualitative and health economic analyses were also included. Results Forty‐five patients were recruited (23 experimental arm, 22 control arm). There were 26 men (58%), and the median age was 78 years (IQR 69–84). At baseline, the median BMI was 26 kg/m2 (IQR: 22–29), and median weight loss in the previous 6 months was 5% (IQR: −12% to 0%). Adherence to the experimental arm was >80% in 16/21 (76%) patients. There was no statistically significant difference in the following between trial arms: step count − median % change from baseline to endpoint, per trial arm (experimental −18.5% [IQR: −61 to 65], control 5% [IQR: −32 to 50], P = 0.548); weight − median % change from baseline to endpoint, per trial arm (experimental 1%[IQR: −3 to 3], control −0.5% [IQR: −3 to 1], P = 0.184); overall quality of life − median % change from baseline to endpoint, per trial arm (experimental 0% [IQR: −20 to 19], control 0% [IQR: −23 to 33], P = 0.846). Qualitative findings observed themes of capability, opportunity, and motivation amongst patients in the experimental arm. The mean incremental cost of the experimental arm versus control was £‐319.51 [CI −7593.53 to 6581.91], suggesting the experimental arm was less costly. Conclusions An exercise and nutritional rehabilitation intervention is feasible and has potential benefits for people with incurable cancer. A larger trial is now warranted to test the efficacy of this approach. |
| first_indexed | 2024-04-11T20:17:04Z |
| format | Article |
| id | doaj.art-64678d7180b348a0b5ffb96dc88e9df3 |
| institution | Directory Open Access Journal |
| issn | 2190-5991 2190-6009 |
| language | English |
| last_indexed | 2024-04-11T20:17:04Z |
| publishDate | 2021-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Cachexia, Sarcopenia and Muscle |
| spelling | doaj.art-64678d7180b348a0b5ffb96dc88e9df32022-12-22T04:04:57ZengWileyJournal of Cachexia, Sarcopenia and Muscle2190-59912190-60092021-12-011262034204410.1002/jcsm.12806A randomized, feasibility trial of an exercise and nutrition‐based rehabilitation programme (ENeRgy) in people with cancerCharlie C. Hall0Richard J.E. Skipworth1Honor Blackwood2Duncan Brown3Jane Cook4Katharina Diernberger5Elizabeth Dixon6Valerie Gibson7Catriona Graham8Peter Hall9Erna Haraldsdottir10Jane Hopkinson11Anna Lloyd12Matthew Maddocks13Lucy Norris14Sharon Tuck15Marie T. Fallon16Barry J.A. Laird17St Columba's Hospice Edinburgh UKClinical Surgery, University of Edinburgh, Royal Infirmary of Edinburgh Edinburgh UKSt Columba's Hospice Edinburgh UKSt Columba's Hospice Edinburgh UKSt Columba's Hospice Edinburgh UKInstitute of Genetics and Cancer University of Edinburgh Edinburgh UKSouthampton Clinical Trials Unit University of Southampton Southampton UKSt Columba's Hospice Edinburgh UKEdinburgh Clinical Research Facility University of Edinburgh Edinburgh UKInstitute of Genetics and Cancer University of Edinburgh Edinburgh UKSt Columba's Hospice Edinburgh UKCardiff University Cardiff UKSt Columba's Hospice Edinburgh UKCicely Saunders Institute of Palliative Care, Policy and Rehabilitation, Kings College London UKInstitute of Genetics and Cancer University of Edinburgh Edinburgh UKEdinburgh Clinical Trials Unit University of Edinburgh Edinburgh UKInstitute of Genetics and Cancer University of Edinburgh Edinburgh UKSt Columba's Hospice Edinburgh UKAbstract Background Despite rehabilitation being increasingly advocated for people living with incurable cancer, there is limited evidence supporting efficacy or component parts. The progressive decline in function and nutritional in this population would support an approach that targets these factors. This trial aimed to assess the feasibility of an exercise and nutrition based rehabilitation programme in people with incurable cancer. Methods We randomized community dwelling adults with incurable cancer to either a personalized exercise and nutrition based programme (experimental arm) or standard care (control arm) for 8 weeks. Endpoints included feasibility, quality of life, physical activity (step count), and body weight. Qualitative and health economic analyses were also included. Results Forty‐five patients were recruited (23 experimental arm, 22 control arm). There were 26 men (58%), and the median age was 78 years (IQR 69–84). At baseline, the median BMI was 26 kg/m2 (IQR: 22–29), and median weight loss in the previous 6 months was 5% (IQR: −12% to 0%). Adherence to the experimental arm was >80% in 16/21 (76%) patients. There was no statistically significant difference in the following between trial arms: step count − median % change from baseline to endpoint, per trial arm (experimental −18.5% [IQR: −61 to 65], control 5% [IQR: −32 to 50], P = 0.548); weight − median % change from baseline to endpoint, per trial arm (experimental 1%[IQR: −3 to 3], control −0.5% [IQR: −3 to 1], P = 0.184); overall quality of life − median % change from baseline to endpoint, per trial arm (experimental 0% [IQR: −20 to 19], control 0% [IQR: −23 to 33], P = 0.846). Qualitative findings observed themes of capability, opportunity, and motivation amongst patients in the experimental arm. The mean incremental cost of the experimental arm versus control was £‐319.51 [CI −7593.53 to 6581.91], suggesting the experimental arm was less costly. Conclusions An exercise and nutritional rehabilitation intervention is feasible and has potential benefits for people with incurable cancer. A larger trial is now warranted to test the efficacy of this approach.https://doi.org/10.1002/jcsm.12806ExerciseNutritionCancerRehabilitation |
| spellingShingle | Charlie C. Hall Richard J.E. Skipworth Honor Blackwood Duncan Brown Jane Cook Katharina Diernberger Elizabeth Dixon Valerie Gibson Catriona Graham Peter Hall Erna Haraldsdottir Jane Hopkinson Anna Lloyd Matthew Maddocks Lucy Norris Sharon Tuck Marie T. Fallon Barry J.A. Laird A randomized, feasibility trial of an exercise and nutrition‐based rehabilitation programme (ENeRgy) in people with cancer Journal of Cachexia, Sarcopenia and Muscle Exercise Nutrition Cancer Rehabilitation |
| title | A randomized, feasibility trial of an exercise and nutrition‐based rehabilitation programme (ENeRgy) in people with cancer |
| title_full | A randomized, feasibility trial of an exercise and nutrition‐based rehabilitation programme (ENeRgy) in people with cancer |
| title_fullStr | A randomized, feasibility trial of an exercise and nutrition‐based rehabilitation programme (ENeRgy) in people with cancer |
| title_full_unstemmed | A randomized, feasibility trial of an exercise and nutrition‐based rehabilitation programme (ENeRgy) in people with cancer |
| title_short | A randomized, feasibility trial of an exercise and nutrition‐based rehabilitation programme (ENeRgy) in people with cancer |
| title_sort | randomized feasibility trial of an exercise and nutrition based rehabilitation programme energy in people with cancer |
| topic | Exercise Nutrition Cancer Rehabilitation |
| url | https://doi.org/10.1002/jcsm.12806 |
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