Structural variation-associated expression changes are paralleled by chromatin architecture modifications.

Structural variation-associated expression changes are paralleled by chromatin architecture modifications.

Copy number variants (CNVs) influence the expression of genes that map not only within the rearrangement, but also to its flanks. To assess the possible mechanism(s) underlying this "neighboring effect", we compared intrachromosomal interactions and histone modifications in cell lines of p...

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Bibliographic Details
Main Authors: Nele Gheldof, Robert M Witwicki, Eugenia Migliavacca, Marion Leleu, Gérard Didelot, Louise Harewood, Jacques Rougemont, Alexandre Reymond
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3827143?pdf=render

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