Gut Microbiota Functional Dysbiosis Relates to Individual Diet in Subclinical Carotid Atherosclerosis
Gut Microbiota (GM) dysbiosis associates with Atherosclerotic Cardiovascular Diseases (ACVD), but whether this also holds true in subjects without clinically manifest ACVD represents a challenge of personalized prevention. We connected exposure to diet (self-reported by food diaries) and markers of...
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MDPI AG
2021-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/2/304 |
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| author | Andrea Baragetti Marco Severgnini Elena Olmastroni Carola Conca Dioguardi Elisa Mattavelli Andrea Angius Luca Rotta Javier Cibella Giada Caredda Clarissa Consolandi Liliana Grigore Fabio Pellegatta Flavio Giavarini Donatella Caruso Giuseppe Danilo Norata Alberico Luigi Catapano Clelia Peano |
| author_facet | Andrea Baragetti Marco Severgnini Elena Olmastroni Carola Conca Dioguardi Elisa Mattavelli Andrea Angius Luca Rotta Javier Cibella Giada Caredda Clarissa Consolandi Liliana Grigore Fabio Pellegatta Flavio Giavarini Donatella Caruso Giuseppe Danilo Norata Alberico Luigi Catapano Clelia Peano |
| author_sort | Andrea Baragetti |
| collection | DOAJ |
| description | Gut Microbiota (GM) dysbiosis associates with Atherosclerotic Cardiovascular Diseases (ACVD), but whether this also holds true in subjects without clinically manifest ACVD represents a challenge of personalized prevention. We connected exposure to diet (self-reported by food diaries) and markers of Subclinical Carotid Atherosclerosis (SCA) with individual taxonomic and functional GM profiles (from fecal metagenomic DNA) of 345 subjects without previous clinically manifest ACVD. Subjects without SCA reported consuming higher amounts of cereals, starchy vegetables, milky products, yoghurts and bakery products versus those with SCA (who reported to consume more mechanically separated meats). The variety of dietary sources significantly overlapped with the separations in GM composition between subjects without SCA and those with SCA (RV coefficient between nutrients quantities and microbial relative abundances at genus level = 0.65, <i>p</i>-value = 0.047). Additionally, specific bacterial species (<i>Faecalibacterium prausnitzii</i> in the absence of SCA and <i>Escherichia coli</i> in the presence of SCA) are directly related to over-representation of metagenomic pathways linked to different dietary sources (sulfur oxidation and starch degradation in absence of SCA, and metabolism of amino acids, syntheses of palmitate, choline, carnitines and Trimethylamine <i>n</i>-oxide in presence of SCA). These findings might contribute to hypothesize future strategies of personalized dietary intervention for primary CVD prevention setting. |
| first_indexed | 2024-03-09T04:04:32Z |
| format | Article |
| id | doaj.art-6472c6a546734ae3b8bc28e5f50e39a8 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T04:04:32Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-6472c6a546734ae3b8bc28e5f50e39a82023-12-03T14:08:09ZengMDPI AGNutrients2072-66432021-01-0113230410.3390/nu13020304Gut Microbiota Functional Dysbiosis Relates to Individual Diet in Subclinical Carotid AtherosclerosisAndrea Baragetti0Marco Severgnini1Elena Olmastroni2Carola Conca Dioguardi3Elisa Mattavelli4Andrea Angius5Luca Rotta6Javier Cibella7Giada Caredda8Clarissa Consolandi9Liliana Grigore10Fabio Pellegatta11Flavio Giavarini12Donatella Caruso13Giuseppe Danilo Norata14Alberico Luigi Catapano15Clelia Peano16Department of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, ItalyInstitute of Biomedical Technologies, National Research Council, 20090 Segrate, Milan, ItalyEpidemiology and Preventive Pharmacology Service (SEFAP), Department of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, ItalyInstitute of Genetic and Biomedical Research, UoS Milan, National Research Council, Rozzano, 20125 Milan, ItalyDepartment of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, ItalyInstitute of Genetic and Biomedical Research, National Research Council, 09042 Cagliari, ItalyDepartment of Experimental Oncology, IEO, European Institute of Oncology, IRCCS, 20141 Milan, ItalyGenomic Unit, IRCCS, Humanitas Clinical and Research Center, 20090 Rozzano, Milan, ItalyDepartment of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, ItalyInstitute of Biomedical Technologies, National Research Council, 20090 Segrate, Milan, ItalyS.I.S.A. Center for the Study of Atherosclerosis, Bassini Hospital, 20092 Cinisello Balsamo, Milan, ItalyS.I.S.A. Center for the Study of Atherosclerosis, Bassini Hospital, 20092 Cinisello Balsamo, Milan, ItalyDepartment of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, ItalyDepartment of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, ItalyDepartment of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, ItalyDepartment of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, ItalyInstitute of Genetic and Biomedical Research, UoS Milan, National Research Council, Rozzano, 20125 Milan, ItalyGut Microbiota (GM) dysbiosis associates with Atherosclerotic Cardiovascular Diseases (ACVD), but whether this also holds true in subjects without clinically manifest ACVD represents a challenge of personalized prevention. We connected exposure to diet (self-reported by food diaries) and markers of Subclinical Carotid Atherosclerosis (SCA) with individual taxonomic and functional GM profiles (from fecal metagenomic DNA) of 345 subjects without previous clinically manifest ACVD. Subjects without SCA reported consuming higher amounts of cereals, starchy vegetables, milky products, yoghurts and bakery products versus those with SCA (who reported to consume more mechanically separated meats). The variety of dietary sources significantly overlapped with the separations in GM composition between subjects without SCA and those with SCA (RV coefficient between nutrients quantities and microbial relative abundances at genus level = 0.65, <i>p</i>-value = 0.047). Additionally, specific bacterial species (<i>Faecalibacterium prausnitzii</i> in the absence of SCA and <i>Escherichia coli</i> in the presence of SCA) are directly related to over-representation of metagenomic pathways linked to different dietary sources (sulfur oxidation and starch degradation in absence of SCA, and metabolism of amino acids, syntheses of palmitate, choline, carnitines and Trimethylamine <i>n</i>-oxide in presence of SCA). These findings might contribute to hypothesize future strategies of personalized dietary intervention for primary CVD prevention setting.https://www.mdpi.com/2072-6643/13/2/304Atherosclerotic Cardiovascular DiseasesGut Microbiotanext generation sequencing |
| spellingShingle | Andrea Baragetti Marco Severgnini Elena Olmastroni Carola Conca Dioguardi Elisa Mattavelli Andrea Angius Luca Rotta Javier Cibella Giada Caredda Clarissa Consolandi Liliana Grigore Fabio Pellegatta Flavio Giavarini Donatella Caruso Giuseppe Danilo Norata Alberico Luigi Catapano Clelia Peano Gut Microbiota Functional Dysbiosis Relates to Individual Diet in Subclinical Carotid Atherosclerosis Nutrients Atherosclerotic Cardiovascular Diseases Gut Microbiota next generation sequencing |
| title | Gut Microbiota Functional Dysbiosis Relates to Individual Diet in Subclinical Carotid Atherosclerosis |
| title_full | Gut Microbiota Functional Dysbiosis Relates to Individual Diet in Subclinical Carotid Atherosclerosis |
| title_fullStr | Gut Microbiota Functional Dysbiosis Relates to Individual Diet in Subclinical Carotid Atherosclerosis |
| title_full_unstemmed | Gut Microbiota Functional Dysbiosis Relates to Individual Diet in Subclinical Carotid Atherosclerosis |
| title_short | Gut Microbiota Functional Dysbiosis Relates to Individual Diet in Subclinical Carotid Atherosclerosis |
| title_sort | gut microbiota functional dysbiosis relates to individual diet in subclinical carotid atherosclerosis |
| topic | Atherosclerotic Cardiovascular Diseases Gut Microbiota next generation sequencing |
| url | https://www.mdpi.com/2072-6643/13/2/304 |
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