Predicting initial nucleation events occurred in a metastable nanodroplet during acoustic droplet vaporization
Acoustic droplet vaporization (ADV) capable of converting liquid perfluorocarbon (PFC) micro/nanodroplets into gaseous microbubbles has gained much attention due to its medical potentials. However, its physical mechanisms for nanodroplets have not been well understood due to the disappeared superhar...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-07-01
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| Series: | Ultrasonics Sonochemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1350417721001504 |
| _version_ | 1818572870760005632 |
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| author | Dui Qin Qingqin Zou Shuang Lei Wei Wang Zhangyong Li |
| author_facet | Dui Qin Qingqin Zou Shuang Lei Wei Wang Zhangyong Li |
| author_sort | Dui Qin |
| collection | DOAJ |
| description | Acoustic droplet vaporization (ADV) capable of converting liquid perfluorocarbon (PFC) micro/nanodroplets into gaseous microbubbles has gained much attention due to its medical potentials. However, its physical mechanisms for nanodroplets have not been well understood due to the disappeared superharmonic focusing effect and the prominent Laplace pressure compared to microdroplets, especially for the initial ADV nucleation occurring in a metastable PFC nanodroplet. The classical nucleation theory (CNT) was modified to describe the ADV nucleation via combining the phase-change thermodynamics of perfluoropentane (PFP) and the Laplace pressure effect on PFP nanodroplets. The thermodynamics was exactly predicted by the Redlich–Kwong equation of state (EoS) rather than the van der Waals EoS, based on which the surface tension of the vapor nucleus as a crucial parameter in the CNT was successfully obtained to modify the CNT. Compared to the CNT, the modified CNT eliminated the intrinsic limitations of the CNT, and it predicted a larger nucleation rate and a lower ADV nucleation threshold, which agree much better with experimental results. Furthermore, it indicated that the nanodroplet properties exert very strong influences on the nucleation threshold instead of the acoustic parameters, providing a potential strategy with an appropriate droplet design to reduce the ADV nucleation threshold. This study may contribute to further understanding the ADV mechanism for PFC nanodroplets and promoting its potential theranostic applications in clinical practice. |
| first_indexed | 2024-12-15T00:03:26Z |
| format | Article |
| id | doaj.art-64730fa3685141e9bc91d49b6d8abf58 |
| institution | Directory Open Access Journal |
| issn | 1350-4177 |
| language | English |
| last_indexed | 2024-12-15T00:03:26Z |
| publishDate | 2021-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ultrasonics Sonochemistry |
| spelling | doaj.art-64730fa3685141e9bc91d49b6d8abf582022-12-21T22:42:49ZengElsevierUltrasonics Sonochemistry1350-41772021-07-0175105608Predicting initial nucleation events occurred in a metastable nanodroplet during acoustic droplet vaporizationDui Qin0Qingqin Zou1Shuang Lei2Wei Wang3Zhangyong Li4Corresponding authors at: No. 2 Chongwen Road, Nan'an District, Chongqing 400065, PR China.; Chongqing Engineering Research Center of Medical Electronics and Information Technology, Department of Biomedical Engineering, School of Bioinformatics, Chongqing University of Posts and Telecommunications, Chongqing 400065, PR ChinaChongqing Engineering Research Center of Medical Electronics and Information Technology, Department of Biomedical Engineering, School of Bioinformatics, Chongqing University of Posts and Telecommunications, Chongqing 400065, PR ChinaChongqing Engineering Research Center of Medical Electronics and Information Technology, Department of Biomedical Engineering, School of Bioinformatics, Chongqing University of Posts and Telecommunications, Chongqing 400065, PR ChinaChongqing Engineering Research Center of Medical Electronics and Information Technology, Department of Biomedical Engineering, School of Bioinformatics, Chongqing University of Posts and Telecommunications, Chongqing 400065, PR ChinaCorresponding authors at: No. 2 Chongwen Road, Nan'an District, Chongqing 400065, PR China.; Chongqing Engineering Research Center of Medical Electronics and Information Technology, Department of Biomedical Engineering, School of Bioinformatics, Chongqing University of Posts and Telecommunications, Chongqing 400065, PR ChinaAcoustic droplet vaporization (ADV) capable of converting liquid perfluorocarbon (PFC) micro/nanodroplets into gaseous microbubbles has gained much attention due to its medical potentials. However, its physical mechanisms for nanodroplets have not been well understood due to the disappeared superharmonic focusing effect and the prominent Laplace pressure compared to microdroplets, especially for the initial ADV nucleation occurring in a metastable PFC nanodroplet. The classical nucleation theory (CNT) was modified to describe the ADV nucleation via combining the phase-change thermodynamics of perfluoropentane (PFP) and the Laplace pressure effect on PFP nanodroplets. The thermodynamics was exactly predicted by the Redlich–Kwong equation of state (EoS) rather than the van der Waals EoS, based on which the surface tension of the vapor nucleus as a crucial parameter in the CNT was successfully obtained to modify the CNT. Compared to the CNT, the modified CNT eliminated the intrinsic limitations of the CNT, and it predicted a larger nucleation rate and a lower ADV nucleation threshold, which agree much better with experimental results. Furthermore, it indicated that the nanodroplet properties exert very strong influences on the nucleation threshold instead of the acoustic parameters, providing a potential strategy with an appropriate droplet design to reduce the ADV nucleation threshold. This study may contribute to further understanding the ADV mechanism for PFC nanodroplets and promoting its potential theranostic applications in clinical practice.http://www.sciencedirect.com/science/article/pii/S1350417721001504Acoustic droplet vaporizationBubble nucleationPhase-change nanodropletsThermodynamics |
| spellingShingle | Dui Qin Qingqin Zou Shuang Lei Wei Wang Zhangyong Li Predicting initial nucleation events occurred in a metastable nanodroplet during acoustic droplet vaporization Ultrasonics Sonochemistry Acoustic droplet vaporization Bubble nucleation Phase-change nanodroplets Thermodynamics |
| title | Predicting initial nucleation events occurred in a metastable nanodroplet during acoustic droplet vaporization |
| title_full | Predicting initial nucleation events occurred in a metastable nanodroplet during acoustic droplet vaporization |
| title_fullStr | Predicting initial nucleation events occurred in a metastable nanodroplet during acoustic droplet vaporization |
| title_full_unstemmed | Predicting initial nucleation events occurred in a metastable nanodroplet during acoustic droplet vaporization |
| title_short | Predicting initial nucleation events occurred in a metastable nanodroplet during acoustic droplet vaporization |
| title_sort | predicting initial nucleation events occurred in a metastable nanodroplet during acoustic droplet vaporization |
| topic | Acoustic droplet vaporization Bubble nucleation Phase-change nanodroplets Thermodynamics |
| url | http://www.sciencedirect.com/science/article/pii/S1350417721001504 |
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