Using Endoscopic Optical Coherence Tomography to Detect and Treat Early-Stage Pancreatic Cancers
We developed a novel technology capable of detecting early-stage pancreatic cancers using high-resolution three-dimensional endoscopic optical coherence tomography (Endo-OCT), and treating them using high dose rate brachytherapy (HDR) under the Endo-OCT image guidance. This technology integrates our...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.591484/full |
| _version_ | 1798028268771737600 |
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| author | Lanchun Lu Zhilin Hu Wendy Frankel Rulong Shen Wei Chen Xueliang Pan John C. Grecula Mark P. Bloomston Mary E. Dillhoff |
| author_facet | Lanchun Lu Zhilin Hu Wendy Frankel Rulong Shen Wei Chen Xueliang Pan John C. Grecula Mark P. Bloomston Mary E. Dillhoff |
| author_sort | Lanchun Lu |
| collection | DOAJ |
| description | We developed a novel technology capable of detecting early-stage pancreatic cancers using high-resolution three-dimensional endoscopic optical coherence tomography (Endo-OCT), and treating them using high dose rate brachytherapy (HDR) under the Endo-OCT image guidance. This technology integrates our custom-built ultra-high resolution endoscopic three-dimensional OCT diagnostic imaging device with a commercial high dose rate brachytherapy system (HDR), resulting in a compact, portable, easy-to-operate, and low-cost Endo-OCT image-guided high dose rate brachytherapy (OCT-IGHDR) system. The system has the dual functions of diagnosis and treatment that can precisely detect and measure the location and size of the early-stage pancreatic cancer or premalignant lesions and then treat them from the inside of the pancreatic duct with an accurate and focused dose while greatly reducing the radiation toxicity to the neighboring tissues and organs. This minimally-invasive treatment technology could avoid the potential complications from surgery and reduces the high operation cost. This technology could also be applied to treat diseases of the esophagus, rectum, bronchus, and other aerodigestive organs that are suitable for use with an endoscopic device. In this article, we describe the concept of this technology and the preliminary experiments that could demonstrate the concept by using this homemade Endo-OCT machine to image the pancreatic duct for diagnosis of early-stage pancreatic cancer or premalignant lesions and to perform Endo-OCT image-guided brachytherapy. |
| first_indexed | 2024-04-11T19:05:13Z |
| format | Article |
| id | doaj.art-6473679904e64fceadfeffd270ff0726 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T19:05:13Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-6473679904e64fceadfeffd270ff07262022-12-22T04:07:49ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-03-011110.3389/fonc.2021.591484591484Using Endoscopic Optical Coherence Tomography to Detect and Treat Early-Stage Pancreatic CancersLanchun Lu0Zhilin Hu1Wendy Frankel2Rulong Shen3Wei Chen4Xueliang Pan5John C. Grecula6Mark P. Bloomston7Mary E. Dillhoff8Department of Radiation Oncology, The James Cancer Hospital and Solove Research Institute, Wexner Medical Center and College of Medicine at the Ohio State University, Columbus, OH, United StatesPharos Scientific, LLC, Lilburn, GA, United StatesDepartment of Pathology, The James Cancer Hospital and Solove Research Institute, Wexner Medical Center and College of Medicine at the Ohio State University, Columbus, OH, United StatesDepartment of Pathology, The James Cancer Hospital and Solove Research Institute, Wexner Medical Center and College of Medicine at the Ohio State University, Columbus, OH, United StatesDepartment of Pathology, The James Cancer Hospital and Solove Research Institute, Wexner Medical Center and College of Medicine at the Ohio State University, Columbus, OH, United StatesDepartment of Biomedical Informatics, College of Medicine at the Ohio State University, Columbus, OH, United StatesDepartment of Radiation Oncology, The James Cancer Hospital and Solove Research Institute, Wexner Medical Center and College of Medicine at the Ohio State University, Columbus, OH, United States21st Century Oncology, Fort Myers, FL, United StatesDepartment of Surgical Oncology, The James Cancer Hospital and Solove Research Institute, Wexner Medical Center and College of Medicine at the Ohio State University, Columbus, OH, United StatesWe developed a novel technology capable of detecting early-stage pancreatic cancers using high-resolution three-dimensional endoscopic optical coherence tomography (Endo-OCT), and treating them using high dose rate brachytherapy (HDR) under the Endo-OCT image guidance. This technology integrates our custom-built ultra-high resolution endoscopic three-dimensional OCT diagnostic imaging device with a commercial high dose rate brachytherapy system (HDR), resulting in a compact, portable, easy-to-operate, and low-cost Endo-OCT image-guided high dose rate brachytherapy (OCT-IGHDR) system. The system has the dual functions of diagnosis and treatment that can precisely detect and measure the location and size of the early-stage pancreatic cancer or premalignant lesions and then treat them from the inside of the pancreatic duct with an accurate and focused dose while greatly reducing the radiation toxicity to the neighboring tissues and organs. This minimally-invasive treatment technology could avoid the potential complications from surgery and reduces the high operation cost. This technology could also be applied to treat diseases of the esophagus, rectum, bronchus, and other aerodigestive organs that are suitable for use with an endoscopic device. In this article, we describe the concept of this technology and the preliminary experiments that could demonstrate the concept by using this homemade Endo-OCT machine to image the pancreatic duct for diagnosis of early-stage pancreatic cancer or premalignant lesions and to perform Endo-OCT image-guided brachytherapy.https://www.frontiersin.org/articles/10.3389/fonc.2021.591484/fullendoscopic optical coherence tomographyearly-stage pancreatic cancerdetect and treatendo-optical coherence tomography–guided brachytherapyhigh-dose rate brachytherapy |
| spellingShingle | Lanchun Lu Zhilin Hu Wendy Frankel Rulong Shen Wei Chen Xueliang Pan John C. Grecula Mark P. Bloomston Mary E. Dillhoff Using Endoscopic Optical Coherence Tomography to Detect and Treat Early-Stage Pancreatic Cancers Frontiers in Oncology endoscopic optical coherence tomography early-stage pancreatic cancer detect and treat endo-optical coherence tomography–guided brachytherapy high-dose rate brachytherapy |
| title | Using Endoscopic Optical Coherence Tomography to Detect and Treat Early-Stage Pancreatic Cancers |
| title_full | Using Endoscopic Optical Coherence Tomography to Detect and Treat Early-Stage Pancreatic Cancers |
| title_fullStr | Using Endoscopic Optical Coherence Tomography to Detect and Treat Early-Stage Pancreatic Cancers |
| title_full_unstemmed | Using Endoscopic Optical Coherence Tomography to Detect and Treat Early-Stage Pancreatic Cancers |
| title_short | Using Endoscopic Optical Coherence Tomography to Detect and Treat Early-Stage Pancreatic Cancers |
| title_sort | using endoscopic optical coherence tomography to detect and treat early stage pancreatic cancers |
| topic | endoscopic optical coherence tomography early-stage pancreatic cancer detect and treat endo-optical coherence tomography–guided brachytherapy high-dose rate brachytherapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.591484/full |
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