Precise sound characteristics drive plasticity in the primary auditory cortex with VNS-sound pairing
IntroductionRepeatedly pairing a tone with vagus nerve stimulation (VNS) alters frequency tuning across the auditory pathway. Pairing VNS with speech sounds selectively enhances the primary auditory cortex response to the paired sounds. It is not yet known how altering the speech sounds paired with...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1248936/full |
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| author | Michael S. Borland Michael S. Borland Elizabeth P. Buell Elizabeth P. Buell Jonathan R. Riley Jonathan R. Riley Alan M. Carroll Alan M. Carroll Nicole A. Moreno Nicole A. Moreno Pryanka Sharma Pryanka Sharma Katelyn M. Grasse Katelyn M. Grasse John M. Buell John M. Buell Michael P. Kilgard Michael P. Kilgard Crystal T. Engineer Crystal T. Engineer |
| author_facet | Michael S. Borland Michael S. Borland Elizabeth P. Buell Elizabeth P. Buell Jonathan R. Riley Jonathan R. Riley Alan M. Carroll Alan M. Carroll Nicole A. Moreno Nicole A. Moreno Pryanka Sharma Pryanka Sharma Katelyn M. Grasse Katelyn M. Grasse John M. Buell John M. Buell Michael P. Kilgard Michael P. Kilgard Crystal T. Engineer Crystal T. Engineer |
| author_sort | Michael S. Borland |
| collection | DOAJ |
| description | IntroductionRepeatedly pairing a tone with vagus nerve stimulation (VNS) alters frequency tuning across the auditory pathway. Pairing VNS with speech sounds selectively enhances the primary auditory cortex response to the paired sounds. It is not yet known how altering the speech sounds paired with VNS alters responses. In this study, we test the hypothesis that the sounds that are presented and paired with VNS will influence the neural plasticity observed following VNS-sound pairing.MethodsTo explore the relationship between acoustic experience and neural plasticity, responses were recorded from primary auditory cortex (A1) after VNS was repeatedly paired with the speech sounds ‘rad’ and ‘lad’ or paired with only the speech sound ‘rad’ while ‘lad’ was an unpaired background sound.ResultsPairing both sounds with VNS increased the response strength and neural discriminability of the paired sounds in the primary auditory cortex. Surprisingly, pairing only ‘rad’ with VNS did not alter A1 responses.DiscussionThese results suggest that the specific acoustic contrasts associated with VNS can powerfully shape neural activity in the auditory pathway. Methods to promote plasticity in the central auditory system represent a new therapeutic avenue to treat auditory processing disorders. Understanding how different sound contrasts and neural activity patterns shape plasticity could have important clinical implications. |
| first_indexed | 2024-03-12T02:28:57Z |
| format | Article |
| id | doaj.art-64789a5436734dd3a51b40dd7dcbd7eb |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-12T02:28:57Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-64789a5436734dd3a51b40dd7dcbd7eb2023-09-05T10:10:51ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-09-011710.3389/fnins.2023.12489361248936Precise sound characteristics drive plasticity in the primary auditory cortex with VNS-sound pairingMichael S. Borland0Michael S. Borland1Elizabeth P. Buell2Elizabeth P. Buell3Jonathan R. Riley4Jonathan R. Riley5Alan M. Carroll6Alan M. Carroll7Nicole A. Moreno8Nicole A. Moreno9Pryanka Sharma10Pryanka Sharma11Katelyn M. Grasse12Katelyn M. Grasse13John M. Buell14John M. Buell15Michael P. Kilgard16Michael P. Kilgard17Crystal T. Engineer18Crystal T. Engineer19Department of Neuroscience, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, United StatesTexas Biomedical Device Center, The University of Texas at Dallas, Richardson, TX, United StatesDepartment of Neuroscience, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, United StatesTexas Biomedical Device Center, The University of Texas at Dallas, Richardson, TX, United StatesDepartment of Neuroscience, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, United StatesTexas Biomedical Device Center, The University of Texas at Dallas, Richardson, TX, United StatesDepartment of Neuroscience, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, United StatesTexas Biomedical Device Center, The University of Texas at Dallas, Richardson, TX, United StatesDepartment of Neuroscience, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, United StatesTexas Biomedical Device Center, The University of Texas at Dallas, Richardson, TX, United StatesDepartment of Neuroscience, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, United StatesTexas Biomedical Device Center, The University of Texas at Dallas, Richardson, TX, United StatesTexas Biomedical Device Center, The University of Texas at Dallas, Richardson, TX, United StatesErik Jonsson School of Engineering and Computer Science, The University of Texas at Dallas, Richardson, TX, United StatesDepartment of Neuroscience, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, United StatesTexas Biomedical Device Center, The University of Texas at Dallas, Richardson, TX, United StatesDepartment of Neuroscience, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, United StatesTexas Biomedical Device Center, The University of Texas at Dallas, Richardson, TX, United StatesDepartment of Neuroscience, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, United StatesTexas Biomedical Device Center, The University of Texas at Dallas, Richardson, TX, United StatesIntroductionRepeatedly pairing a tone with vagus nerve stimulation (VNS) alters frequency tuning across the auditory pathway. Pairing VNS with speech sounds selectively enhances the primary auditory cortex response to the paired sounds. It is not yet known how altering the speech sounds paired with VNS alters responses. In this study, we test the hypothesis that the sounds that are presented and paired with VNS will influence the neural plasticity observed following VNS-sound pairing.MethodsTo explore the relationship between acoustic experience and neural plasticity, responses were recorded from primary auditory cortex (A1) after VNS was repeatedly paired with the speech sounds ‘rad’ and ‘lad’ or paired with only the speech sound ‘rad’ while ‘lad’ was an unpaired background sound.ResultsPairing both sounds with VNS increased the response strength and neural discriminability of the paired sounds in the primary auditory cortex. Surprisingly, pairing only ‘rad’ with VNS did not alter A1 responses.DiscussionThese results suggest that the specific acoustic contrasts associated with VNS can powerfully shape neural activity in the auditory pathway. Methods to promote plasticity in the central auditory system represent a new therapeutic avenue to treat auditory processing disorders. Understanding how different sound contrasts and neural activity patterns shape plasticity could have important clinical implications.https://www.frontiersin.org/articles/10.3389/fnins.2023.1248936/fullneuromodulationvagus nerve stimulationplasticityauditory cortexspeech |
| spellingShingle | Michael S. Borland Michael S. Borland Elizabeth P. Buell Elizabeth P. Buell Jonathan R. Riley Jonathan R. Riley Alan M. Carroll Alan M. Carroll Nicole A. Moreno Nicole A. Moreno Pryanka Sharma Pryanka Sharma Katelyn M. Grasse Katelyn M. Grasse John M. Buell John M. Buell Michael P. Kilgard Michael P. Kilgard Crystal T. Engineer Crystal T. Engineer Precise sound characteristics drive plasticity in the primary auditory cortex with VNS-sound pairing Frontiers in Neuroscience neuromodulation vagus nerve stimulation plasticity auditory cortex speech |
| title | Precise sound characteristics drive plasticity in the primary auditory cortex with VNS-sound pairing |
| title_full | Precise sound characteristics drive plasticity in the primary auditory cortex with VNS-sound pairing |
| title_fullStr | Precise sound characteristics drive plasticity in the primary auditory cortex with VNS-sound pairing |
| title_full_unstemmed | Precise sound characteristics drive plasticity in the primary auditory cortex with VNS-sound pairing |
| title_short | Precise sound characteristics drive plasticity in the primary auditory cortex with VNS-sound pairing |
| title_sort | precise sound characteristics drive plasticity in the primary auditory cortex with vns sound pairing |
| topic | neuromodulation vagus nerve stimulation plasticity auditory cortex speech |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1248936/full |
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