The Interaction between Cyclin B1 and Cytomegalovirus Protein Kinase pUL97 is Determined by an Active Kinase Domain

The Interaction between Cyclin B1 and Cytomegalovirus Protein Kinase pUL97 is Determined by an Active Kinase Domain

Replication of human cytomegalovirus (HCMV) is characterized by a tight virus-host cell interaction. Cyclin-dependent protein kinases (CDKs) are functionally integrated into viral gene expression and protein modification. The HCMV-encoded protein kinase pUL97 acts as a CDK ortholog showing structura...

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Bibliographic Details
Main Authors: Mirjam Steingruber, Eileen Socher, Corina Hutterer, Rike Webel, Tim Bergbrede, Tihana Lenac, Heinrich Sticht, Manfred Marschall
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:Viruses
Subjects:
human cytomegalovirus
protein kinase pUL97
CDK ortholog
cyclin B
protein-protein interaction
kinase activity
mode of kinase-cyclin interaction
active conformation
Online Access:http://www.mdpi.com/1999-4915/7/8/2834

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