Two types of somatostatin-expressing GABAergic interneurons in the superficial layers of the mouse cingulate cortex.
Somatostatin-expressing (SOM+), inhibitory interneurons represent a heterogeneous group of cells and given their remarkable diversity, classification of SOM+ interneurons remains a challenging task. Electrophysiological, morphological and neurochemical classes of SOM+ interneurons have been proposed...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6042774?pdf=render |
| _version_ | 1818675363427909632 |
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| author | Therese Riedemann Tobias Straub Bernd Sutor |
| author_facet | Therese Riedemann Tobias Straub Bernd Sutor |
| author_sort | Therese Riedemann |
| collection | DOAJ |
| description | Somatostatin-expressing (SOM+), inhibitory interneurons represent a heterogeneous group of cells and given their remarkable diversity, classification of SOM+ interneurons remains a challenging task. Electrophysiological, morphological and neurochemical classes of SOM+ interneurons have been proposed in the past but it remains unclear as to what extent these classes are congruent. We performed whole-cell patch-clamp recordings from 127 GFP-labeled SOM+ interneurons ('GIN') of the superficial cingulate cortex with subsequent biocytin-filling and immunocytochemical labeling. Principal component analysis followed by k-means clustering predicted two putative subtypes of SOM+ interneurons, which we designated as group I and group II GIN. A key finding of our study is the fact that these electrophysiologically and morphologically distinct groups of SOM+ interneurons can be correlated with two neurochemical subtypes of SOM+ interneurons described recently in our laboratory. In particular, all SOM+ interneurons expressing calbindin but no calretinin could be classified as group I GIN, whereas all but one neuropeptide Y- and calretinin-positive interneurons were found in group II. |
| first_indexed | 2024-12-17T08:26:23Z |
| format | Article |
| id | doaj.art-647daf90ff2b4d10be01083dda6a9ae6 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T08:26:23Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-647daf90ff2b4d10be01083dda6a9ae62022-12-21T21:56:45ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01137e020056710.1371/journal.pone.0200567Two types of somatostatin-expressing GABAergic interneurons in the superficial layers of the mouse cingulate cortex.Therese RiedemannTobias StraubBernd SutorSomatostatin-expressing (SOM+), inhibitory interneurons represent a heterogeneous group of cells and given their remarkable diversity, classification of SOM+ interneurons remains a challenging task. Electrophysiological, morphological and neurochemical classes of SOM+ interneurons have been proposed in the past but it remains unclear as to what extent these classes are congruent. We performed whole-cell patch-clamp recordings from 127 GFP-labeled SOM+ interneurons ('GIN') of the superficial cingulate cortex with subsequent biocytin-filling and immunocytochemical labeling. Principal component analysis followed by k-means clustering predicted two putative subtypes of SOM+ interneurons, which we designated as group I and group II GIN. A key finding of our study is the fact that these electrophysiologically and morphologically distinct groups of SOM+ interneurons can be correlated with two neurochemical subtypes of SOM+ interneurons described recently in our laboratory. In particular, all SOM+ interneurons expressing calbindin but no calretinin could be classified as group I GIN, whereas all but one neuropeptide Y- and calretinin-positive interneurons were found in group II.http://europepmc.org/articles/PMC6042774?pdf=render |
| spellingShingle | Therese Riedemann Tobias Straub Bernd Sutor Two types of somatostatin-expressing GABAergic interneurons in the superficial layers of the mouse cingulate cortex. PLoS ONE |
| title | Two types of somatostatin-expressing GABAergic interneurons in the superficial layers of the mouse cingulate cortex. |
| title_full | Two types of somatostatin-expressing GABAergic interneurons in the superficial layers of the mouse cingulate cortex. |
| title_fullStr | Two types of somatostatin-expressing GABAergic interneurons in the superficial layers of the mouse cingulate cortex. |
| title_full_unstemmed | Two types of somatostatin-expressing GABAergic interneurons in the superficial layers of the mouse cingulate cortex. |
| title_short | Two types of somatostatin-expressing GABAergic interneurons in the superficial layers of the mouse cingulate cortex. |
| title_sort | two types of somatostatin expressing gabaergic interneurons in the superficial layers of the mouse cingulate cortex |
| url | http://europepmc.org/articles/PMC6042774?pdf=render |
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