Ultrasound‐Driven Piezoelectrocatalytic Immunoactivation of Deep Tumor
Abstract Tumor heterogeneity makes routine drugs difficult to penetrate solid tumors, limiting their therapy efficacies. Based on high tissue penetrability of hydrogen molecules (H2) and ultrasound (US) and the immunomodulation effects of H2 and lactic acid (LA), this work proposes a novel strategy...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-10-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202303016 |
| _version_ | 1797663871517851648 |
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| author | Anbang Wu Lingdong Jiang Chao Xia Qingqing Xu Bin Zhou Zhaokui Jin Qianjun He Jinxiao Guo |
| author_facet | Anbang Wu Lingdong Jiang Chao Xia Qingqing Xu Bin Zhou Zhaokui Jin Qianjun He Jinxiao Guo |
| author_sort | Anbang Wu |
| collection | DOAJ |
| description | Abstract Tumor heterogeneity makes routine drugs difficult to penetrate solid tumors, limiting their therapy efficacies. Based on high tissue penetrability of hydrogen molecules (H2) and ultrasound (US) and the immunomodulation effects of H2 and lactic acid (LA), this work proposes a novel strategy of US‐driven piezoelectrocatalytic tumor immunoactivation for high‐efficacy therapy of deep tumors by piezoelectrocatalytic hydrogen generation and LA deprivation. A kind of US‐responsive piezoelectric SnS nanosheets (SSN) is developed to realize US‐triggered local hydrogen production and simultaneous LA deprivation in deep tumors. The proof‐of‐concept experiments which are executed on an orthotopic liver cancer model have verified that intratumoral SSN‐medicated piezoelectrocatalytically generated H2 liberates effector CD8+ T cells from the immunosuppression of tumor cells through down‐regulating PD‐L1 over‐expression, and simultaneous LA deprivation activates CD8+ T cells by inhibiting regulatory T cells, efficiently co‐activating tumor immunity and achieving a high outcome of liver tumor therapy with complete tumor eradication and 100% mice survival. The proposed strategy of US‐driven piezoelectrocatalytic tumor immunoactivation opens a safe and efficient pathway for deep tumor therapy. |
| first_indexed | 2024-03-11T19:22:06Z |
| format | Article |
| id | doaj.art-647f643b0b414212960493329b85ab7f |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-03-11T19:22:06Z |
| publishDate | 2023-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-647f643b0b414212960493329b85ab7f2023-10-07T03:51:50ZengWileyAdvanced Science2198-38442023-10-011028n/an/a10.1002/advs.202303016Ultrasound‐Driven Piezoelectrocatalytic Immunoactivation of Deep TumorAnbang Wu0Lingdong Jiang1Chao Xia2Qingqing Xu3Bin Zhou4Zhaokui Jin5Qianjun He6Jinxiao Guo7Department of Orthopaedics Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai Jiao Tong University Shanghai 200233 ChinaSchool of Biomedical Engineering Shenzhen University Medical School Shenzhen Guangdong 518060 ChinaSchool of Biomedical Engineering Shenzhen University Medical School Shenzhen Guangdong 518060 ChinaSchool of Biomedical Engineering Shenzhen University Medical School Shenzhen Guangdong 518060 ChinaSchool of Biomedical Engineering Shenzhen University Medical School Shenzhen Guangdong 518060 ChinaSchool of Biomedical Engineering Shenzhen University Medical School Shenzhen Guangdong 518060 ChinaSchool of Biomedical Engineering Shenzhen University Medical School Shenzhen Guangdong 518060 ChinaDepartment of Orthopaedics Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai Jiao Tong University Shanghai 200233 ChinaAbstract Tumor heterogeneity makes routine drugs difficult to penetrate solid tumors, limiting their therapy efficacies. Based on high tissue penetrability of hydrogen molecules (H2) and ultrasound (US) and the immunomodulation effects of H2 and lactic acid (LA), this work proposes a novel strategy of US‐driven piezoelectrocatalytic tumor immunoactivation for high‐efficacy therapy of deep tumors by piezoelectrocatalytic hydrogen generation and LA deprivation. A kind of US‐responsive piezoelectric SnS nanosheets (SSN) is developed to realize US‐triggered local hydrogen production and simultaneous LA deprivation in deep tumors. The proof‐of‐concept experiments which are executed on an orthotopic liver cancer model have verified that intratumoral SSN‐medicated piezoelectrocatalytically generated H2 liberates effector CD8+ T cells from the immunosuppression of tumor cells through down‐regulating PD‐L1 over‐expression, and simultaneous LA deprivation activates CD8+ T cells by inhibiting regulatory T cells, efficiently co‐activating tumor immunity and achieving a high outcome of liver tumor therapy with complete tumor eradication and 100% mice survival. The proposed strategy of US‐driven piezoelectrocatalytic tumor immunoactivation opens a safe and efficient pathway for deep tumor therapy.https://doi.org/10.1002/advs.202303016hydrogen therapyimmune activationnanomedicinepiezoelectric catalysistumor immunotherapy |
| spellingShingle | Anbang Wu Lingdong Jiang Chao Xia Qingqing Xu Bin Zhou Zhaokui Jin Qianjun He Jinxiao Guo Ultrasound‐Driven Piezoelectrocatalytic Immunoactivation of Deep Tumor Advanced Science hydrogen therapy immune activation nanomedicine piezoelectric catalysis tumor immunotherapy |
| title | Ultrasound‐Driven Piezoelectrocatalytic Immunoactivation of Deep Tumor |
| title_full | Ultrasound‐Driven Piezoelectrocatalytic Immunoactivation of Deep Tumor |
| title_fullStr | Ultrasound‐Driven Piezoelectrocatalytic Immunoactivation of Deep Tumor |
| title_full_unstemmed | Ultrasound‐Driven Piezoelectrocatalytic Immunoactivation of Deep Tumor |
| title_short | Ultrasound‐Driven Piezoelectrocatalytic Immunoactivation of Deep Tumor |
| title_sort | ultrasound driven piezoelectrocatalytic immunoactivation of deep tumor |
| topic | hydrogen therapy immune activation nanomedicine piezoelectric catalysis tumor immunotherapy |
| url | https://doi.org/10.1002/advs.202303016 |
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